公开(公告)号：US08232282B2

公开(公告)日：2012-07-31

申请号：US12311335

申请日：2007-09-28

申请人： Keiji Nakamura ,  Hiroyuki Nakagawa ,  Yoko Kan

发明人： Keiji Nakamura ,  Hiroyuki Nakagawa ,  Yoko Kan

IPC分类号： A01N43/00

CPC分类号： C07D471/04

摘要： The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R1 is lower alkyl, cyclic lower alkyl. etc.; R2 is H, lower alkyl, lower alkenyl, etc.; R3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or —N(R4)—; R4 is H or lower alkyl; or R2 and R4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.

摘要翻译： 本发明涉及下式（I）的双环嘧啶化合物或其盐。 其中R1是低级烷基，环状低级烷基。 等等。; R2是H，低级烷基，低级烯基等; R3是H，低级烷基，低级烯基等; X是O，S或-N（R 4） - ; R4是H或低级烷基; 或者R 2和R 4可以相互结合形成环状氨基; Y是酰胺基，酮基，磺酰基等; R5是H或低级烷基; Z是O或S; m和n为1或2.所述化合物（I）或其盐具有MGAT抑制活性，可用作治疗或预防肥胖，代谢综合征，高脂血症，高中性脂肪血症，超VLDL-mia，hyper 脂肪酸血症，糖尿病，动脉硬化。

公开(公告)号：US20100093771A1

公开(公告)日：2010-04-15

申请号：US12311335

申请日：2007-09-28

申请人： Keiji Nakamura ,  Hiroyuki Nakagawa ,  Yoko Kan

发明人： Keiji Nakamura ,  Hiroyuki Nakagawa ,  Yoko Kan

IPC分类号： A61K31/519 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R1 is lower alkyl, cyclic lower alkyl. etc.; R2 is H, lower alkyl, lower alkenyl, etc.; R3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or —N(R4)—; R4 is H or lower, alkyl; or R2 and R4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.

摘要翻译： 本发明涉及下式（I）的双环嘧啶化合物或其盐。 其中R1是低级烷基，环状低级烷基。 等等。; R2是H，低级烷基，低级烯基等; R3是H，低级烷基，低级烯基等; X是O，S或-N（R 4） - ; R4为H或更低，烷基; 或者R 2和R 4可以相互结合形成环状氨基; Y是酰胺基，酮基，磺酰基等; R5是H或低级烷基; Z是O或S; m和n为1或2.所述化合物（I）或其盐具有MGAT抑制活性，可用作治疗或预防肥胖，代谢综合征，高脂血症，高中性脂肪血症，超VLDL-mia，hyper 脂肪酸血症，糖尿病，动脉硬化。

公开(公告)号：US08383726B2

公开(公告)日：2013-02-26

申请号：US12439089

申请日：2007-08-29

申请人： Osamu Okunaka ,  Hiroyuki Nishii ,  Takashi Shouji ,  Keiji Nakamura ,  Tae Uk Kim ,  Byung Choon Lee

发明人： Osamu Okunaka ,  Hiroyuki Nishii ,  Takashi Shouji ,  Keiji Nakamura ,  Tae Uk Kim ,  Byung Choon Lee

IPC分类号： C08F257/02 ,  C08F279/02 ,  C08L51/04 ,  C08L55/02

CPC分类号： C08L51/003 ,  C08F257/02 ,  C08F279/02 ,  C08F291/00 ,  C08L51/04 ,  C08L55/02 ,  C08L2666/02 ,  C08L2666/14

摘要： Disclosed is a thermoplastic resin composition having excellent impact resistance at a low temperature, while maintaining high transparency; this thermoplastic resin composition is obtained by compounding an impact resistance improver into a thermoplastic resin, the impact resistance improver being composed of a graft copolymer which is obtained by polymerizing a vinyl monomer component in the presence of a polymer mixture containing a polymer having butadiene units as an essential component and a polymer having styrene units as an essential component, the polymer mixture containing 45 to 65% by mass of the butadiene units and 35 to 55% by mass of the styrene units.

摘要翻译： 公开了一种在保持高透明度的同时在低温下具有优异的耐冲击性的热塑性树脂组合物; 这种热塑性树脂组合物是通过将耐冲击性改进剂混合到热塑性树脂中获得的，该耐冲击性改进剂由接枝共聚物组成，该接枝共聚物是通过在含有具有丁二烯单元的聚合物的聚合物混合物存在下聚合乙烯基单体组分 必需成分和具有苯乙烯单元作为必要成分的聚合物，该聚合物混合物含有45〜65质量％的丁二烯单元和35〜55质量％的苯乙烯单元。

公开(公告)号：US20100067351A1

公开(公告)日：2010-03-18

申请号：US12447573

申请日：2007-08-15

申请人： Mitoru Yabe ,  Keiji Nakamura

发明人： Mitoru Yabe ,  Keiji Nakamura

IPC分类号： G11B7/00 ,  B29C65/00

CPC分类号： G11B7/0935 ,  G11B7/1374 ,  G11B7/22 ,  G11B2007/0006

摘要： An objective lens driving apparatus includes an objective lens (13) collecting a light flux emitted from a light source on a optical disk (11), and a lens holder (14) holding the objective lens (13). The lens holder (14) includes a first bonding portion (14i) and a second bonding portion (14j) for holding the objective lens (13) by means of bonding. The objective lens (13) is fixed to the lens holder (14) by applying a first bonding adhesive (25) to the first bonding portion (14i) to thereby bond the objective lens (13) thereto, adjusting an inclination of an optical axis of the objective lens (13) while causing the first bonding adhesive (25) to deform, and applying a second bonding adhesive (26) to the second bonding portion (14j). The second bonding adhesive (26) has a larger Young's modulus after curing than the first bonding adhesive (25).

摘要翻译： 一种物镜驱动装置，包括：收集从光源发出的光束在光盘（11）上的光束的物镜;以及保持物镜（13）的透镜保持架（14）。 透镜架（14）包括用于通过接合来保持物镜（13）的第一接合部分（14i）和第二接合部分（14j）。 通过向第一接合部分（14i）施加第一粘合剂（25）将物镜（13）固定到透镜保持器（14），从而将物镜（13）接合到其上，调节光轴的倾斜度 同时使第一粘合剂（25）变形，并将第二粘合剂（26）施加到第二接合部分（14j）上。 第二粘合剂（26）的硬化后的杨氏模量比第一粘合剂（25）的杨氏模量大。

公开(公告)号：US07514452B2

公开(公告)日：2009-04-07

申请号：US10503215

申请日：2003-01-30

申请人： Akihito Fujii ,  Toshiyuki Negoro ,  Chiaki Migihashi ,  Makoto Murata ,  Keiji Nakamura ,  Takashi Nukuda ,  Takafumi Matsumoto ,  Kiyomi Imano

发明人： Akihito Fujii ,  Toshiyuki Negoro ,  Chiaki Migihashi ,  Makoto Murata ,  Keiji Nakamura ,  Takashi Nukuda ,  Takafumi Matsumoto ,  Kiyomi Imano

IPC分类号： A61K31/47 ,  C07D307/02 ,  C07D405/00

CPC分类号： C07D405/12 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4709 ,  A61K31/5377 ,  C07D307/68 ,  C07D405/04 ,  C07D407/12 ,  C07D407/14 ,  C07D409/04 ,  C07D409/12

摘要： The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof: wherein A is a group represented by Formula (a) or the like: (wherein either R4 or R5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R1 or R2 represents a group: -D-(X)m-R6 or the like, and the other represents a group: -E-(Y)n-R7, hydrogen atom, aryl or the like; R3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent O or the like; R6 and R7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted.

摘要翻译： 本发明提供由下述通式（I）表示的2-呋喃甲酰肼化合物及其前药，生理学上可接受的盐，水合物，溶剂合物：其中A为由式（a）等表示的基团：（其中R 4 或R 5表示氰基，硝基等，另一个表示氢原子等）。 R 1或R 2表示基团：-D-（X）m -R 6等，另一个表示基团：-E-（Y）n -R 7，氢原子，芳基等; R3是氢原子等; D和E独立地表示芳基; X和Y独立地表示O等; R6和R7独立地表示烷基，芳基，芳烷基等; 并且m和n独立地为0或1，条件是芳基任选被取代。

公开(公告)号：US07209260B1

公开(公告)日：2007-04-24

申请号：US09618537

申请日：2000-07-18

申请人： Hiroshi Tanaka ,  Yoshiyuki Nakai ,  Toru Adachi ,  Keiji Nakamura ,  Tokiyuki Okano ,  Kohsuke Harada

发明人： Hiroshi Tanaka ,  Yoshiyuki Nakai ,  Toru Adachi ,  Keiji Nakamura ,  Tokiyuki Okano ,  Kohsuke Harada

IPC分类号： G06K15/02

CPC分类号： H04N1/3935 ,  G06T1/60 ,  G06T3/40

摘要： The object of the present invention is to use the same FIFO line memory for both enlargement and reduction during variable-magnification processing in the scan direction, allowing reduction in circuit board area, reduction in power consumption, and reduction in cost, and to provide an image processing apparatus that allows variable-magnification processing to be carried out such that the speed of a scanning unit that captures image data during variable-magnification processing in the cross-scan direction is constant. During processing to enlarge an image in the scan direction, image data travels from CCD circuit board, passing through gate b of selector, is written to and read from FIFO memory, and from gate b of selector is written to memory provided at variable magnification unit. At variable magnification unit, image data is read from memory a plurality of times in correspondence to enlargement ratio, changing the magnification of the image data. Furthermore, image data is output through gate a of selector to LSU unit. During processing to reduce an image, image data travels from CCD circuit board, passing through gate a of selector, is input to variable magnification unit where it is subjected to variable-magnification processing, passes through gate a of selector, is written to and read from FIFO memory, passes through gate b of selector, and is output to LSU unit.

摘要翻译： 本发明的目的是在扫描方向的可变放大处理期间使用相同的FIFO行存储器进行放大和缩小，从而减少电路板面积，降低功耗并降低成本，并且提供 允许进行可变放大处理的图像处理装置，使得在横扫描方向的可变放大处理期间捕获图像数据的扫描单元的速度是恒定的。 在扫描方向放大图像的处理过程中，图像数据从CCD电路板行进，通过选择器的栅极b，被写入FIFO存储器并从FIFO存储器读取，并从选择器的栅极b写入可变倍率单位 。 在可变放大单元处，对应于放大率，从存储器多次读取图像数据，改变图像数据的放大率。 此外，图像数据通过选择器的门A输出到LSU单元。 在减少图像的处理过程中，图像数据从CCD电路板行进，通过选通器的门a，被输入到可变放大单元，经过可变放大处理，通过选通器的门a，被写入并读取 从FIFO存储器通过选择器的门b，并输出到LSU单元。

公开(公告)号：US20060217496A1

公开(公告)日：2006-09-28

申请号：US10548444

申请日：2004-03-09

申请人： Takashi Miura ,  Keiji Nakamura ,  Mari Sekita ,  Masahiro Osuka

发明人： Takashi Miura ,  Keiji Nakamura ,  Mari Sekita ,  Masahiro Osuka

IPC分类号： C08L67/04 ,  C08L69/00 ,  C08F2/24

CPC分类号： C08L69/00 ,  C08L51/04 ,  C08L2666/24

摘要： The present invention provides a thermoplastic resin composition capable of demonstrating impact strength, and high resistance to hydrolysis and heat discoloration without impairing the essential properties of the thermoplastic resin. The present invention provides a thermoplastic resin composition containing: 70 to 99% by mass of thermoplastic resin (A) containing a polycarbonate resin as an essential component; and 1 to 30% by mass of graft copolymer (B) which is a graft copolymer obtained by emulsion graft polymerization of a monomer or monomer mixture containing at least alkyl methacrylate in the presence of a latex containing a butadiene rubber polymer, wherein the amount of the butadiene rubber polymer included is in the range of 55 to 90% by mass, and the graft copolymer (B) is obtained by using 0.05 to 10 parts by mass of sodium alkylphenylether disulfonate with respect to 100 parts by mass of the graft copolymer (B).

摘要翻译： 本发明提供能够显示冲击强度，耐水解性和耐热变色性而不损害热塑性树脂的基本性能的热塑性树脂组合物。 本发明提供一种热塑性树脂组合物，其含有70〜99质量％的含有聚碳酸酯树脂作为必要成分的热塑性树脂（A） 和1〜30质量％的接枝共聚物（B），其是通过在含有丁二烯橡胶聚合物的胶乳存在下，至少含有甲基丙烯酸烷基酯的单体或单体混合物的乳液接枝聚合得到的接枝共聚物，其中， 所含的丁二烯橡胶聚合物的含量为55〜90质量％，相对于100质量份的接枝共聚物，使用0.05〜10质量份的烷基苯基醚二磺酸钠，得到接枝共聚物（B） B）。

公开(公告)号：US20050076353A1

公开(公告)日：2005-04-07

申请号：US10644029

申请日：2003-08-20

申请人： Keiji Nakamura ,  Mitoru Yabe

发明人： Keiji Nakamura ,  Mitoru Yabe

IPC分类号： G11B7/09 ,  G11B7/085

CPC分类号： G11B7/0933 ,  G11B7/0935

摘要： An objective lens driving apparatus is used for accurately positioning an abject to focus a light spot on an optical recording medium. A lens holder holds the objective lens and has a bearing hole through which a shaft extends in a direction parallel to the optical axis so that the lens holder is rotatably supported on the shaft. Two magnets are supported on the lens holder so that the shaft is between the magnets. A base has two magnetic members disposed such that each of the two magnets exerts an attraction force on a corresponding one of the two magnetic members to urge the lens holder in a direction of the optical axis and in a direction perpendicular to the optical axis. A first coil set of first focusing and tracking coils and a second coil set of focusing and tracking coils are mounted to the two magnetic members.

摘要翻译： 使用物镜驱动装置来准确地定位凹痕以将光斑聚焦在光记录介质上。 透镜架保持物镜并具有一轴承孔，轴在该支承孔中沿着与光轴平行的方向延伸，从而透镜架可旋转地支撑在轴上。 两个磁体被支撑在透镜夹持器上，使得轴在磁体之间。 底座具有两个磁性构件，其被布置成使得两个磁体中的每一个在两个磁性构件中的对应的一个上施加吸引力，以沿着光轴的方向并且在垂直于光轴的方向上推动透镜保持器。 第一线圈组的第一聚焦跟踪线圈和第二线圈组的聚焦和跟踪线圈安装在两个磁性部件上。

公开(公告)号：US06833409B2

公开(公告)日：2004-12-21

申请号：US10257405

申请日：2002-10-21

申请人： Keiji Nakamura ,  Masakazu Ito

发明人： Keiji Nakamura ,  Masakazu Ito

IPC分类号： C08L5104

CPC分类号： C08L51/003 ,  C08F257/00 ,  C08F265/04 ,  C08F273/00 ,  C08L51/04 ,  C08L2666/02

摘要： An impact strength modifier comprises an acrylic rubber graft copolymer (I) obtained by graft-polymerizing a polyalkyl (meth)acrylate composite rubber (A) with a vinyl monomer (B), and a compound (II) which has a sulfonic acid group or a sulfuric acid group and also has two or more benzene ring skeletons, or a salt thereof. The polyalkyl (meth)acrylate composite rubber (A) contains two or more acrylic rubber components each having a different glass transition temperature, and the respective acrylic rubber components have 20% by weight or less of a monomer having two or more unsaturated bonds in a molecule. The compound (II) preferably has two or more benzene ring skeletons, and a particle size distribution of the polyalkyl (meth)acrylate composite rubber (A) is preferably a polydisperse distribution in which two or more peaks exist within a specific range. When using the impact strength modifier of the present invention, the impact resistance, particularly low-temperature impact resistance of the resin can be improved in a small amount and weatherability such as fading resistance or impact resistance of the resulting molded article can be satisfactorily maintained.

摘要翻译： 冲击强度改性剂包括通过使（甲基）丙烯酸烷基酯复合橡胶与乙烯基单体（B）接枝聚合得到的丙烯酸橡胶接枝共聚物（I）和具有磺酸基的化合物（II）或 硫酸基，也可以具有2个以上的苯环骨架或其盐。 聚（甲基）丙烯酸烷基酯复合橡胶（A）含有两种或多种各自具有不同玻璃化转变温度的丙烯酸橡胶组分，各种丙烯酸类橡胶组分在20％（重量）或更少的具有两个或更多个不饱和键的单体中 分子。 化合物（II）优选具有两个以上的苯环骨架，聚（甲基）丙烯酸聚烷酯复合橡胶（A）的粒径分布优选为在特定范围内存在两个以上峰的多分散分布。 当使用本发明的冲击强度调节剂时，可以少量地提高树脂的耐冲击性，特别是低温耐冲击性，并且可以令人满意地保持所得模制品的耐候性，如抗褪色性或耐冲击性。

公开(公告)号：US06687062B2

公开(公告)日：2004-02-03

申请号：US10246398

申请日：2002-09-19

申请人： Keiji Nakamura ,  Mitoru Yabe

发明人： Keiji Nakamura ,  Mitoru Yabe

IPC分类号： G02B702

CPC分类号： G11B7/0933 ,  G11B7/0935

摘要： An objective lens driving apparatus is used for accurately positioning an abject to focus a light spot on an optical recording medium. A lens holder holds the objective lens and has a bearing hole through which a shaft extends in a direction parallel to the optical axis so that the lens holder is rotatably supported on the shaft. Two magnets are supported on the lens holder so that the shaft is between the magnets. A base has two magnetic members disposed such that each of the two magnets exerts an attraction force on a corresponding one of the two magnetic members to urge the lens holder in a direction of the optical axis and in a direction perpendicular to the optical axis. A first coil set of first focusing and tracking coils and a second coil set of focusing and tracking coils are mounted to the two magnetic members.

摘要翻译： 使用物镜驱动装置来准确地定位凹痕以将光斑聚焦在光记录介质上。 透镜架保持物镜并具有一轴承孔，轴在该支承孔中沿着与光轴平行的方向延伸，从而透镜架可旋转地支撑在轴上。 两个磁体被支撑在透镜夹持器上，使得轴在磁体之间。 底座具有两个磁性构件，其被布置成使得两个磁体中的每一个在两个磁性构件中的对应的一个上施加吸引力，以沿着光轴的方向并且在垂直于光轴的方向上推动透镜保持器。 第一线圈组的第一聚焦跟踪线圈和第二线圈组的聚焦和跟踪线圈安装在两个磁性部件上。