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公开(公告)号:US20070167498A1
公开(公告)日:2007-07-19
申请号:US10544646
申请日:2004-02-06
申请人: Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
发明人: Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
IPC分类号: A61K31/44 , A61K31/35 , A61K31/343 , A61K31/195
CPC分类号: C07D213/65 , C07C235/42 , C07C235/44 , C07C235/46 , C07C237/30 , C07D209/18 , C07D209/30 , C07D213/55 , C07D309/14 , C07D317/64 , C07D317/66 , C07D405/12 , C07D407/04 , C07D409/04
摘要: The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要翻译: 本发明涉及式(I)的羧酸化合物:其中R 1是H,烷基; m为2,3; n为0-2; R 2是苯基,萘基,苯并呋喃,苯并噻吩; Q是-CH 2 -O-Cyc 1,-CH 2 -Cyc2,-L-Cyc 3; R 3a和R 3b各自独立地是氢,烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐,其制备方法的制备方法和包含其的药剂作为活性成分。 式(I)化合物对PGE2受体具有拮抗作用,特别是作为其亚型的EP 3受体,可用于预防和/或治疗 瘙痒,疼痛,尿失禁或压力疾病。
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公开(公告)号:US20060214940A1
公开(公告)日:2006-09-28
申请号:US10551223
申请日:2004-03-26
申请人: Atsushi Kinoshita , Susumu Tanase , Yukio Mori , Atsuhiro Yamashita , Masutaka Inoue , Shigeo Kinoshita
发明人: Atsushi Kinoshita , Susumu Tanase , Yukio Mori , Atsuhiro Yamashita , Masutaka Inoue , Shigeo Kinoshita
IPC分类号: G09G5/02
CPC分类号: G09G3/3208 , G09G3/2096 , G09G2310/0221 , G09G2320/0233 , G09G2320/0673 , G09G2320/08 , G09G2360/147 , G09G2360/16
摘要: An uneven display correction method including a first step of dividing a display area of a display panel into a plurality of unit areas, the first step setting one arbitrary unit area among the unit areas at a reference area, the first step previously determining a value as a correction parameter in each unit area, the value corresponding to a difference between a light-emission start gradation level of the unit area and the light-emission start gradation level of the reference area; and a second step of correcting an input video signal based on the correction parameter determined in each unit area.
摘要翻译: 一种不均匀显示校正方法,包括将显示面板的显示区域划分为多个单位区域的第一步骤,第一步骤在参考区域设置单位区域中的一个任意单位区域,将第一步骤先确定为值 每个单位区域中的校正参数,对应于单位面积的发光开始灰度级与基准区的发光开始灰度级之间的差的值; 以及基于在每个单位区域中确定的校正参数校正输入视频信号的第二步骤。
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公开(公告)号:US20060175051A1
公开(公告)日:2006-08-10
申请号:US11192017
申请日:2005-07-29
申请人: Atsushi Kinoshita
发明人: Atsushi Kinoshita
IPC分类号: G05D23/00
CPC分类号: G05D23/1919
摘要: A temperature regulator having a heat exchange unit and a power supply and control unit and providing a heat-exchange apparatus, which can be installed in a minimal space and yet is very easy to handle. The temperature regulator includes a heat exchange unit which has a tank, a pump and a heat exchanger, and circulates a liquid to exchange heat with circulating liquid, and a power supply and control unit which has a power supply and control means, and controls temperature of the circulating liquid, wherein the heat exchange unit and the power supply and control unit are arranged in an interior of a main frame.
摘要翻译: 一种温度调节器,其具有热交换单元和电源和控制单元,并且提供可安装在最小空间内并且非常容易处理的热交换装置。 温度调节器包括具有罐,泵和热交换器的热交换单元,并且循环液体以与循环液体进行热交换;以及电源和控制单元,其具有电源和控制装置,并且控制温度 的循环液体,其中所述热交换单元和所述电源和控制单元布置在主框架的内部。
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24.
公开(公告)号:US5856218A
公开(公告)日:1999-01-05
申请号:US851537
申请日:1997-05-05
申请人: Atsushi Kinoshita , Tomohisa Wada
发明人: Atsushi Kinoshita , Tomohisa Wada
IPC分类号: H01L29/73 , H01L21/331 , H01L21/8249 , H01L27/06 , H01L29/732 , H01L21/8238
CPC分类号: H01L21/8249 , Y10S148/009
摘要: In an NPN bipolar transistor having a special structure in which each impurity region is formed by ion implantation, a width of a base region is significantly reduced, and therefore, current amplification factor hfe is increased, resulting in improvement in performance thereof. Furthermore, a Bi-CMOS transistor can be manufactured using a CMOS process. The use of the bipolar transistor having a special structure for a driving circuit allows implementation of a driving circuit having large driving force with slight increase in cost.
摘要翻译: 在具有通过离子注入形成每个杂质区域的特殊结构的NPN双极晶体管中,基极区域的宽度显着降低,因此电流放大系数hfe增加,从而提高其性能。 此外,可以使用CMOS工艺制造Bi-CMOS晶体管。 使用具有用于驱动电路的特殊结构的双极晶体管允许实现具有大的驱动力的驱动电路,同时成本略有增加。
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