公开(公告)号：US20070167498A1

公开(公告)日：2007-07-19

申请号：US10544646

申请日：2004-02-06

申请人： Masaki Asada ,  Kaoru Kobayashi ,  Masami Narita ,  Kazutoyo Sato ,  Atsushi Kinoshita ,  Toshihiko Nagase ,  Ken Yoshikawa

发明人： Masaki Asada ,  Kaoru Kobayashi ,  Masami Narita ,  Kazutoyo Sato ,  Atsushi Kinoshita ,  Toshihiko Nagase ,  Ken Yoshikawa

IPC分类号： A61K31/44 ,  A61K31/35 ,  A61K31/343 ,  A61K31/195

CPC分类号： C07D213/65 ,  C07C235/42 ,  C07C235/44 ,  C07C235/46 ,  C07C237/30 ,  C07D209/18 ,  C07D209/30 ,  C07D213/55 ,  C07D309/14 ,  C07D317/64 ,  C07D317/66 ,  C07D405/12 ,  C07D407/04 ,  C07D409/04

摘要： The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.

摘要翻译： 本发明涉及式（I）的羧酸化合物：其中R 1是H，烷基; m为2,3; n为0-2; R 2是苯基，萘基，苯并呋喃，苯并噻吩; Q是-CH 2 -O-Cyc 1，-CH 2 -Cyc2，-L-Cyc 3; R 3a和R 3b各自独立地是氢，烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐，其制备方法的制备方法和包含其的药剂作为活性成分。 式（I）化合物对PGE2受体具有拮抗作用，特别是作为其亚型的EP 3受体，可用于预防和/或治疗 瘙痒，疼痛，尿失禁或压力疾病。

公开(公告)号：US20060214940A1

公开(公告)日：2006-09-28

申请号：US10551223

申请日：2004-03-26

申请人： Atsushi Kinoshita ,  Susumu Tanase ,  Yukio Mori ,  Atsuhiro Yamashita ,  Masutaka Inoue ,  Shigeo Kinoshita

发明人： Atsushi Kinoshita ,  Susumu Tanase ,  Yukio Mori ,  Atsuhiro Yamashita ,  Masutaka Inoue ,  Shigeo Kinoshita

IPC分类号： G09G5/02

CPC分类号： G09G3/3208 ,  G09G3/2096 ,  G09G2310/0221 ,  G09G2320/0233 ,  G09G2320/0673 ,  G09G2320/08 ,  G09G2360/147 ,  G09G2360/16

摘要： An uneven display correction method including a first step of dividing a display area of a display panel into a plurality of unit areas, the first step setting one arbitrary unit area among the unit areas at a reference area, the first step previously determining a value as a correction parameter in each unit area, the value corresponding to a difference between a light-emission start gradation level of the unit area and the light-emission start gradation level of the reference area; and a second step of correcting an input video signal based on the correction parameter determined in each unit area.

摘要翻译： 一种不均匀显示校正方法，包括将显示面板的显示区域划分为多个单位区域的第一步骤，第一步骤在参考区域设置单位区域中的一个任意单位区域，将第一步骤先确定为值 每个单位区域中的校正参数，对应于单位面积的发光开始灰度级与基准区的发光开始灰度级之间的差的值; 以及基于在每个单位区域中确定的校正参数校正输入视频信号的第二步骤。

公开(公告)号：US20060175051A1

公开(公告)日：2006-08-10

申请号：US11192017

申请日：2005-07-29

申请人： Atsushi Kinoshita

发明人： Atsushi Kinoshita

IPC分类号： G05D23/00

CPC分类号： G05D23/1919

摘要： A temperature regulator having a heat exchange unit and a power supply and control unit and providing a heat-exchange apparatus, which can be installed in a minimal space and yet is very easy to handle. The temperature regulator includes a heat exchange unit which has a tank, a pump and a heat exchanger, and circulates a liquid to exchange heat with circulating liquid, and a power supply and control unit which has a power supply and control means, and controls temperature of the circulating liquid, wherein the heat exchange unit and the power supply and control unit are arranged in an interior of a main frame.

摘要翻译： 一种温度调节器，其具有热交换单元和电源和控制单元，并且提供可安装在最小空间内并且非常容易处理的热交换装置。 温度调节器包括具有罐，泵和热交换器的热交换单元，并且循环液体以与循环液体进行热交换;以及电源和控制单元，其具有电源和控制装置，并且控制温度 的循环液体，其中所述热交换单元和所述电源和控制单元布置在主框架的内部。

公开(公告)号：US06194681B1

公开(公告)日：2001-02-27

申请号：US09498077

申请日：2000-02-04

申请人： Haruo Moriguchi ,  Tetsuro Ikeda ,  Kenzo Danjou ,  Atsushi Kinoshita

发明人： Haruo Moriguchi ,  Tetsuro Ikeda ,  Kenzo Danjou ,  Atsushi Kinoshita

IPC分类号： B23K1000

CPC分类号： B23K9/1043 ,  B23K9/091 ,  B23K9/1006

摘要： A DC voltage resulting from rectifying and smoothing a commercial AC voltage is converted into a high-frequency voltage in an inverter which is operated in response to the closure of a start switch. A transformer transforms the high-frequency voltage, and the voltage-transformed high-frequency voltage is converted to a DC voltage by a rectifier and reactor for application between a torch and a workpiece with a gap disposed therebetween. In response to the closure of the start switch, an igniter operated from the voltage-transformed high-frequency voltage is enabled by an igniter driver to thereby apply a high-frequency voltage between the torch and the workpiece to generate an arc therebetween. A current detector detects current attributable to the arcing. A timer starts operating upon closure of the start switch and causes a disabling commander to disable the inverter when no current is detected by the current detector during a time period longer than a period required for an arc to be generated in the gap. This interrupts the supply of the operating voltage for the igniter, and the igniter stops operating.

摘要翻译： 在商业交流电压的整流和平滑中产生的直流电压被转换成响应于启动开关闭合而操作的逆变器中的高频电压。 变压器转换高频电压，并且通过整流器和电抗器将电压变换的高频电压转换为直流电压，以在喷枪和工件之间施加间隙，间隙设置在其间。 响应于启动开关的闭合，由电压变换的高频电压操作的点火器由点火器驱动器实现，从而在割炬和工件之间施加高频电压，以在它们之间产生电弧。 电流检测器检测归因于电弧的电流。 定时器在起动开关闭合时开始操作，并且当电流检测器没有检测到电流在比在间隙中产生电弧所需的时间段更长的时间段内使得禁用指令器禁用逆变器。 这将中断点火器的工作电压供应，点火器停止工作。

公开(公告)号：US5877952A

公开(公告)日：1999-03-02

申请号：US954816

申请日：1997-10-21

申请人： Haruo Moriguchi ,  Kenzo Danjo ,  Shigeru Okamoto ,  Atsushi Kinoshita ,  Takashi Hashimoto

发明人： Haruo Moriguchi ,  Kenzo Danjo ,  Shigeru Okamoto ,  Atsushi Kinoshita ,  Takashi Hashimoto

IPC分类号： B23K9/067 ,  B23K9/073 ,  H02M3/28 ,  H02M9/00 ,  H02M7/00

CPC分类号： B23K9/0678

摘要： Power supply apparatus includes a converter which converts a commercial AC voltage into a DC voltage. An inverter converts the DC voltage into a high frequency voltage. The high frequency voltage is voltage-transformed by a transformer, and then rectified and smoothed by a rectifier and a smoothing reactor into a DC voltage. This DC voltage is applied between a workpiece and a torch. A high frequency voltage generator generates a high frequency voltage and applies it to a primary winding of a coupling transformer. A boosted high frequency voltage is induced in a first secondary winding and applied between the workpiece and the torch, so that arcing is initiated. The coupling transformer includes a second secondary winding in which another high frequency voltage is induced. The high frequency voltage induced in the second secondary winding is converted into a DC voltage by a diode and a smoothing capacitor for application between the workpiece and the torch, so that the arcing is sustained.

摘要翻译： 电源装置包括将商用AC电压转换成DC电压的转换器。 逆变器将直流电压转换成高频电压。 高频电压由变压器进行电压转换，然后由整流器和平滑电抗器整流并平滑成直流电压。 该直流电压施加在工件和割炬之间。 高频电压发生器产生高频电压并将其施加到耦合变压器的初级绕组。 在第一次级绕组中感应出升高的高频电压，并施加在工件和割炬之间，从而启动电弧。 耦合变压器包括其中引入另一高频电压的第二次级绕组。 在第二次级绕组中感应的高频电压通过二极管和平滑电容器转换成直流电压，用于工件和焊炬之间的应用，从而保持电弧。

公开(公告)号：US5856218A

公开(公告)日：1999-01-05

申请号：US851537

申请日：1997-05-05

申请人： Atsushi Kinoshita ,  Tomohisa Wada

发明人： Atsushi Kinoshita ,  Tomohisa Wada

IPC分类号： H01L29/73 ,  H01L21/331 ,  H01L21/8249 ,  H01L27/06 ,  H01L29/732 ,  H01L21/8238

CPC分类号： H01L21/8249 ,  Y10S148/009

摘要： In an NPN bipolar transistor having a special structure in which each impurity region is formed by ion implantation, a width of a base region is significantly reduced, and therefore, current amplification factor hfe is increased, resulting in improvement in performance thereof. Furthermore, a Bi-CMOS transistor can be manufactured using a CMOS process. The use of the bipolar transistor having a special structure for a driving circuit allows implementation of a driving circuit having large driving force with slight increase in cost.

摘要翻译： 在具有通过离子注入形成每个杂质区域的特殊结构的NPN双极晶体管中，基极区域的宽度显着降低，因此电流放大系数hfe增加，从而提高其性能。 此外，可以使用CMOS工艺制造Bi-CMOS晶体管。 使用具有用于驱动电路的特殊结构的双极晶体管允许实现具有大的驱动力的驱动电路，同时成本略有增加。

公开(公告)号：US5751568A

公开(公告)日：1998-05-12

申请号：US758691

申请日：1996-12-03

申请人： Kenzo Danjo ,  Atsushi Kinoshita ,  Shigeru Okamoto ,  Haruo Moriguchi ,  Takashi Hashimoto

发明人： Kenzo Danjo ,  Atsushi Kinoshita ,  Shigeru Okamoto ,  Haruo Moriguchi ,  Takashi Hashimoto

IPC分类号： B23K9/10 ,  H02M7/48 ,  H02M3/335 ,  H23K9/095

CPC分类号： B23K9/1056 ,  H02M7/48

摘要： A power supply apparatus for arc-utilizing equipment includes a first converter for converting a received AC voltage to a DC voltage. An inverter converts the DC voltage to a high-frequency voltage, which is applied to a voltage-transformer with primary and second windings. A voltage-transformed high-frequency voltage induced in the secondary winding is converted to a DC voltage in a second converter, which is developed between two output terminals. The respective ones of the two output terminals are connected to a torch electrode of the arc-utilizing equipment and a workpiece. A bypass capacitor and a high-frequency voltage generator circuit are serially connected between the two output terminals. A control circuit controls the high-frequency voltage generator circuit and the inverter circuit. The bypass capacitor is connected directly between one of the two output terminals and the high-frequency voltage generator circuit.

摘要翻译： 用于电弧利用设备的电源装置包括用于将接收的AC电压转换为DC电压的第一转换器。 逆变器将直流电压转换为施加到具有初级和第二绕组的电压互感器的高频电压。 在次级绕组中感应的电压变换的高频电压被转换成在两个输出端之间产生的第二转换器中的直流电压。 两个输出端子中的相应的端子连接到电弧利用设备的炬电极和工件。 旁路电容器和高频电压发生器电路串联连接在两个输出端子之间。 控制电路控制高频电压发生器电路和逆变器电路。 旁路电容器直接连接在两个输出端子之一和高频电压发生器电路之间。

公开(公告)号：US08138335B2

公开(公告)日：2012-03-20

申请号：US12551860

申请日：2009-09-01

申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

IPC分类号： C07D265/36 ,  A61K31/535

CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

公开(公告)号：US07748435B2

公开(公告)日：2010-07-06

申请号：US11192017

申请日：2005-07-29

申请人： Atsushi Kinoshita

发明人： Atsushi Kinoshita

IPC分类号： G05D23/00

CPC分类号： G05D23/1919

摘要： A temperature regulator having a heat exchange unit and a power supply and control unit and providing a heat-exchange apparatus, which can be installed in a minimal space and yet is very easy to handle. The temperature regulator includes a heat exchange unit which has a tank, a pump and a heat exchanger, and circulates a liquid to exchange heat with circulating liquid, and a power supply and control unit which has a power supply and control device, and controls temperature of the circulating liquid. The heat exchange unit and the power supply and control unit are arranged in an interior of a main frame.

摘要翻译： 一种温度调节器，其具有热交换单元和电源和控制单元，并且提供可安装在最小空间内并且非常容易处理的热交换装置。 温度调节器包括具有罐，泵和热交换器的热交换单元，并且循环液体以与循环液体进行热交换;以及电源和控制单元，其具有电源和控制装置，并且控制温度 的循环液体。 热交换单元和电源和控制单元布置在主框架的内部。

公开(公告)号：US5457300A

公开(公告)日：1995-10-10

申请号：US285002

申请日：1994-08-02

申请人： Kunio Karino ,  Haruo Moriguchi ,  Toshikazu Fujiyoshi ,  Kenzo Danjo ,  Atsushi Kinoshita

发明人： Kunio Karino ,  Haruo Moriguchi ,  Toshikazu Fujiyoshi ,  Kenzo Danjo ,  Atsushi Kinoshita

IPC分类号： B23K9/073 ,  B23K9/095 ,  H02M7/537 ,  H02M9/00

CPC分类号： B23K9/0956

摘要： An inverter controlled DC arc welder of consumable electrode type includes an input rectifier for rectifying AC input power, an inverter for converting the rectifier output to high frequency AC power, an output transformer for stepping down the inverter output voltage, and an output rectifier for rectifying the transformer output voltage to provide a DC output voltage to be applied to a welder load. The welder further includes means for detecting current flowing through the welder load to produce a detection signal, a differentiator circuit for differentiating the detection signal, and correction means for correcting a predetermined reference voltage in accordance with the differentiator output voltage. Feedback control means controls the inverter in accordance with the difference between the transformer output and the corrected reference voltage.

摘要翻译： 一种易损电极类型的逆变器控制直流电弧焊机，包括用于整流交流输入电源的输入整流器，用于将整流器输出转换为高频交流电的逆变器，用于降低逆变器输出电压的输出变压器，以及用于整流的输出整流器 变压器输出电压提供要施加到焊机负载的直流输出电压。 焊机还包括用于检测流过焊机负载的电流以产生检测信号的装置，用于区分检测信号的微分电路和用于根据微分器输出电压校正预定参考电压的校正装置。 反馈控制装置根据变压器输出与校正参考电压之间的差异来控制变频器。