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公开(公告)号：US08609686B2
公开(公告)日：2013-12-17
申请号：US12809674
申请日：2008-12-09
申请人： Peter Nell , Alexandros Vakalopoulos , Frank Süβmeier , Barbara Albrecht-Küpper , Katja Zimmerman , Joerg Keldenich , Daniel Meibom
发明人： Peter Nell , Alexandros Vakalopoulos , Frank Süβmeier , Barbara Albrecht-Küpper , Katja Zimmerman , Joerg Keldenich , Daniel Meibom
IPC分类号： A01N43/42 , A61K31/44 , A01N43/40 , C07D471/02 , C07D491/02 , C07D498/02 , C07D221/02 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted pyrrolopyridine, pyrazolopyridine and isoxazolopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的吡咯并吡啶，吡唑并吡啶和异恶唑并吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物 用于治疗和/或预防心血管疾病。
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公开(公告)号：US08426602B2
公开(公告)日：2013-04-23
申请号：US12922172
申请日：2009-02-26
申请人： Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Katja Zimmermann , Peter Nell , Frank Süβmeier
发明人： Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Katja Zimmermann , Peter Nell , Frank Süβmeier
IPC分类号： C07D211/78 , A61K31/695
CPC分类号： C07D417/14 , C07D401/14 , C07D409/04 , C07D413/14
摘要： The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的杂芳基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗 和/或预防心血管疾病。
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公开(公告)号：US20110294718A1
公开(公告)日：2011-12-01
申请号：US12671694
申请日：2008-07-23
申请人： Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
发明人： Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
IPC分类号： A61K38/05 , A61P9/00 , C07D417/14 , C07D417/12 , A61K31/4439
CPC分类号： A61K47/48246 , A61K31/4439 , A61K47/542 , A61K47/64 , C07D417/12 , C07K5/06086
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫基）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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公开(公告)号：US20110207698A1
公开(公告)日：2011-08-25
申请号：US12922172
申请日：2009-02-26
申请人： Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Katja Zimmermann , Peter Nell , Frank Süßmeier
发明人： Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Katja Zimmermann , Peter Nell , Frank Süßmeier
IPC分类号： A61K31/695 , C07D401/14 , A61K31/4439 , A61K31/397 , C07D401/04 , A61K31/4436 , A61K31/444 , C07F7/18 , A61P9/00 , A61P3/00
CPC分类号： C07D417/14 , C07D401/14 , C07D409/04 , C07D413/14
摘要： The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的杂芳基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗 和/或预防心血管疾病。
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公开(公告)号：US20110003845A1
公开(公告)日：2011-01-06
申请号：US12809674
申请日：2008-12-09
申请人： Peter Nell , Alexandros Vakalopoulos , Frank Süssmeier , Barbara Albrecht-Küpper , Katja Zimmermann , Jörg Keldenich , Daniel Meibom
发明人： Peter Nell , Alexandros Vakalopoulos , Frank Süssmeier , Barbara Albrecht-Küpper , Katja Zimmermann , Jörg Keldenich , Daniel Meibom
IPC分类号： A61K31/437 , C07D471/04 , A61K31/4439 , C07D417/12 , C07D401/14 , A61K31/444 , A61P9/12 , A61P3/10
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted pyrrolopyridine, pyrazolopyridine and isoxazolopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的吡咯并吡啶，吡唑并吡啶和异恶唑并吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物 用于治疗和/或预防心血管疾病。
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26.发明申请公开(公告)号：US20100069363A1
公开(公告)日：2010-03-18
申请号：US12516939
申请日：2007-11-17
申请人： Peter Nell , Nicole Diedrichs , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Joerg Keldenich
发明人： Peter Nell , Nicole Diedrichs , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Joerg Keldenich
IPC分类号： A61K31/4439 , C07D417/14 , C07D401/14 , A61K31/4545 , A61K31/496 , A61K31/55 , A61K31/5377 , A61P9/12 , A61P9/00 , A61P3/10 , A61P3/00
CPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The present application relates to novel substituted 4-amino-3,5-dicyano-2-thiopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-氨基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗的药物的用途 和/或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20100028264A1
公开(公告)日：2010-02-04
申请号：US12444596
申请日：2007-10-02
申请人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
发明人： Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.
摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病相关的LTBP2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制LTBP2的活性的化合物以及包含这些化合物的药物组合物。 本发明还提供LTBP2作为心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病等疾病的生物标志物。
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28.发明授权公开(公告)号：US08703934B2
公开(公告)日：2014-04-22
申请号：US12516939
申请日：2007-11-17
申请人： Peter Nell , Nicole Diedrichs , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süβmeier , Joerg Keldenich
发明人： Peter Nell , Nicole Diedrichs , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süβmeier , Joerg Keldenich
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The present application relates to novel substituted 4-amino-3,5-dicyano-2-thiopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-氨基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗的药物的用途 和/或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20130210797A1
公开(公告)日：2013-08-15
申请号：US13819790
申请日：2011-08-29
申请人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meiibom
发明人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meiibom
IPC分类号： C07D417/12 , A61K45/06 , C07D417/14 , A61K31/4439 , C07D413/12
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
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30.发明授权公开(公告)号：US08420825B2
公开(公告)日：2013-04-16
申请号：US12697000
申请日：2010-01-29
申请人： Alexandros Vakalopoulos , Daniel Meibom , Barbara Albrecht-Küpper , Katja Zimmermann , Jörg Keldenich , Hans-Georg Lerchen , Peter Nell , Frank Süssmeier , Ursula Krenz
发明人： Alexandros Vakalopoulos , Daniel Meibom , Barbara Albrecht-Küpper , Katja Zimmermann , Jörg Keldenich , Hans-Georg Lerchen , Peter Nell , Frank Süssmeier , Ursula Krenz
IPC分类号： A61K31/44 , C07D409/00
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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