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公开(公告)号：US20240057595A1
公开(公告)日：2024-02-22
申请号：US18270285
申请日：2021-12-29
申请人： Manus Bio Inc.
IPC分类号： A01N35/06 , A01N27/00 , A01N31/06 , A01P17/00 , A01N43/24 , A01N37/18 , A01N37/42 , A01N65/28
CPC分类号： A01N35/06 , A01N27/00 , A01N31/06 , A01P17/00 , A01N43/24 , A01N37/18 , A01N37/42 , A01N65/28
摘要： The present disclosure provides insect and/or arachnid repellent compositions, and methods of use thereof. The compositions disclosed herein comprise nootkatone and one or more fragrance agents and/or non-fragrance agents effective to for repelling the insects or arachnids. The fragrance or non-fragrance agents in various embodiments alter or mask human sweat odor, are effective to repel insects or arachnids, and/or alter or inhibit insect or arachnid olfactory systems.
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公开(公告)号：US20210022373A1
公开(公告)日：2021-01-28
申请号：US16862214
申请日：2020-04-29
申请人： Manus Bio, Inc.
发明人： Ryan PHILIPPE , Ajikumar Parayil KUMARAN , Jason DONALD , Krishna PATEL , Swati GUPTA , Ryan LIM , Liwei LI
摘要： The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
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公开(公告)号：US20210009968A1
公开(公告)日：2021-01-14
申请号：US16912374
申请日：2020-06-25
申请人： Manus Bio, Inc.
发明人： Jason Eric DONALD , Ajikumar Parayil KUMARAN , Aaron LOVE , Christopher TOOMEY , Christine Nicole S. SANTOS
摘要： In various aspects, the present invention provides uridine diphosphate-dependent glycosyltransferase (UGT) enzymes capable of catalyzing the transfer of a monosaccharide moiety from a NDP-sugar to the 3′ carbon of a sugar moiety of a substrate, such as a terpenoid glycan, thereby functioning as a “1-3 UGT.” In other aspects, the invention provides polynucleotides encoding the 1-3 UGT, and host cells comprising the same. In still other aspects, the invention provides methods for preparing glycosylated substrates, including steviol glycosides, using the enzyme and host cells of this disclosure.
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公开(公告)号：US20200377865A1
公开(公告)日：2020-12-03
申请号：US16990424
申请日：2020-08-11
申请人： Manus Bio, Inc.
发明人： Jason DONALD , Christopher PIRIE , Liwei LI , Huey-Ming MAK , Srishti TIBREWALA , Ajikumar Parayil KUMARAN
摘要： The present invention relates to the production of chemical species in bacterial host cells. Particularly, the present invention provides for the production of chemical species in Escherichia coli (E. coli) host cells that functionally express engineered P450 enzymes.
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公开(公告)号：US20200299735A1
公开(公告)日：2020-09-24
申请号：US16862209
申请日：2020-04-29
申请人： Manus Bio, Inc.
发明人： Ajikumar Parayil KUMARAN , Chin-Giaw LIM , Souvik GHOSH , Christopher PIRIE , Jason DONALD , Aaron LOVE , Hong NAN , Hsien-Chung TSENG , Christine Nicole S. SANTOS , Ryan PHILIPPE
摘要： In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
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公开(公告)号：US20200002733A1
公开(公告)日：2020-01-02
申请号：US16570251
申请日：2019-09-13
申请人： MANUS BIO INC.
发明人： Ajikumar Parayil KUMARAN , Ryan LIM , Jason DONALD , Hsien-Chung TSENG , Christine Nicole S. SANTOS , Ryan PHILIPPE
摘要： The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
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