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公开(公告)号：US20220251607A1
公开(公告)日：2022-08-11
申请号：US17729096
申请日：2022-04-26
申请人： MANUS BIO INC.
发明人： Ajikumar Parayil KUMARAN , Ryan LIM , Jason DONALD , Hsien-Chung TSENG , Christine Nicole S. SANTOS , Ryan PHILIPPE
摘要： The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
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公开(公告)号：US20210002672A1
公开(公告)日：2021-01-07
申请号：US16992773
申请日：2020-08-13
申请人： Manus Bio, Inc.
发明人： Ajikumar Parayil KUMARAN , Ryan LIM , Jason DONALD , Hsien-Chung TSENG , Christine Nicole S. SANTOS , Ryan PHILIPPE
摘要： The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
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公开(公告)号：US20240215615A1
公开(公告)日：2024-07-04
申请号：US18467362
申请日：2023-09-14
申请人： Manus Bio Inc.
发明人： Ryan PHILIPPE , Ajikumar Parayil KUMARAN , Jason DONALD , Krishna PATEL , Swati GUPTA , Ryan LIM , Liwei LI
CPC分类号： A23L2/60 , A23L27/36 , C12N9/0073 , C12N9/1048 , C12N9/1051 , C12P19/56 , C12Y114/13079 , C12Y204/01017 , A23V2002/00
摘要： The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
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公开(公告)号：US20190269157A1
公开(公告)日：2019-09-05
申请号：US16251993
申请日：2019-01-18
申请人： Manus Bio, Inc.
发明人： Ryan PHILIPPE , Ajikumar Parayil KUMARAN , Jason DONALD , Krishna PATEL , Swati GUPTA , Ryan LIM , Liwei LI
摘要： The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
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公开(公告)号：US20180216137A1
公开(公告)日：2018-08-02
申请号：US15881386
申请日：2018-01-26
申请人： Manus Bio, Inc.
发明人： Ajikumar Parayil KUMARAN , Ryan LIM , Jason DONALD , Hsien-Chung TSENG , Christine SANTOS , Ryan PHILIPPE
摘要： The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
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公开(公告)号：US20210022373A1
公开(公告)日：2021-01-28
申请号：US16862214
申请日：2020-04-29
申请人： Manus Bio, Inc.
发明人： Ryan PHILIPPE , Ajikumar Parayil KUMARAN , Jason DONALD , Krishna PATEL , Swati GUPTA , Ryan LIM , Liwei LI
摘要： The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
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公开(公告)号：US20200002733A1
公开(公告)日：2020-01-02
申请号：US16570251
申请日：2019-09-13
申请人： MANUS BIO INC.
发明人： Ajikumar Parayil KUMARAN , Ryan LIM , Jason DONALD , Hsien-Chung TSENG , Christine Nicole S. SANTOS , Ryan PHILIPPE
摘要： The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
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