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公开(公告)号：US6136559A
公开(公告)日：2000-10-24
申请号：US167354
申请日：1998-10-07
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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22.发明授权Methods of use of DNA encoding a human histamine receptor of the H3 subtype 有权使用编码H3亚型的人组胺受体的DNA的方法公开(公告)号：US07179604B2
公开(公告)日：2007-02-20
申请号：US10727021
申请日：2003-12-02
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US20050164342A1
公开(公告)日：2005-07-28
申请号：US10641149
申请日：2003-08-15
Applicant: Allan Tobin , Mark Erlander , Daniel Kaufman
Inventor： Allan Tobin , Mark Erlander , Daniel Kaufman
IPC: A61K38/00 , A61K38/51 , A61K51/00 , A61P3/10 , A61P21/02 , A61P37/02 , C12N1/21 , C12N9/88 , C12N11/00 , C12N15/09 , C12N15/60 , C12Q1/527 , C12Q1/68 , C12R1/01 , G01N33/53 , G01N33/564 , G01N33/573 , C07H21/04 , C07K16/40
CPC classification number: C12Y401/01015 , A61K38/00 , C12N9/88 , G01N33/564 , G01N2800/042
Abstract: cDNA molecules coding for GAD65 polypeptide. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD65 which encode at least one epitope for autoantibodies to GAD65. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD65. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD65. In another embodiment, the invention provides for the detection of autoantibodies to GAD65 using the GAD65 polypeptides coded for by the cDNA molecules of the invention.
Abstract translation: 编码GAD 65多肽的cDNA分子。 本发明提供cDNA分子，其包含编码至少一个表位用于自身抗体至GAD 65的GAD 65 cDNA的一部分cDNA序列。 本发明还提供能够复制和表达的克隆载体，其包含编码GAD 65的cDNA分子。 本发明还提供了用载体转化的宿主，其具有编码GAD 65的cDNA分子。 在另一个实施方案中，本发明提供使用本发明的cDNA分子编码的GAD 65多肽来检测GAD 65的自身抗体。
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公开(公告)号：US20050084897A1
公开(公告)日：2005-04-21
申请号：US10985156
申请日：2004-11-10
Applicant: Adrienne Dubin , Arne Huvar , Charles Glass , Mark Erlander
Inventor： Adrienne Dubin , Arne Huvar , Charles Glass , Mark Erlander
IPC: G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/04 , A61P29/00 , A61P31/22 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , G01N33/15 , C12Q1/68 , C07H21/04
CPC classification number: C07K14/705 , A61K38/00
Abstract: DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 编码人VR1受体的DNA已被克隆和表征。 重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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Patent Agency Ranking
公开(公告)号：US20050130194A1
公开(公告)日：2005-06-16
申请号：US10942252
申请日：2004-09-15
Applicant: Mark Erlander , Ranelle Salunga
Inventor： Mark Erlander , Ranelle Salunga
CPC classification number: C12Q1/686 , C12N15/1096 , C12Q1/6865 , C12Q2525/173 , C12Q2525/143
Abstract: The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.
Abstract translation: 本发明提供了扩增核酸分子的方法。 提供了使用寡核苷酸，DNA和RNA聚合酶扩增靶多核苷酸（包括mRNA）的方法。 本发明还提供了用于实施该方法的组合物和试剂盒，以及使用扩增产物的方法。
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公开(公告)号：US07049401B1
公开(公告)日：2006-05-23
申请号：US09642853
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US20060063170A1
公开(公告)日：2006-03-23
申请号：US11084582
申请日：2005-03-18
Applicant: Mark Erlander , Li Ding
Inventor： Mark Erlander , Li Ding
CPC classification number: C12Q1/6851 , C12Q1/68 , C12Q2545/101 , C12Q2545/114 , C12Q2531/113 , C12Q2525/161
Abstract: This invention relates to the determination of RNA quality, or RNA integrity, in a biological sample. The extent of RNA degradation, or retention of RNA integrity, is determined based upon the comparison of the relative amount of two sequences of a representative RNA molecule in the sample. Compositions and methods related to the determination are provided to assess RNA quality.
Abstract translation: 本发明涉及生物样品中RNA质量或RNA完整性的确定。 基于样品中代表性的RNA分子的两个序列的相对量的比较来确定RNA降解的程度或RNA完整性的保留。 提供与测定有关的组合物和方法以评估RNA质量。
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28.发明申请公开(公告)号：US20050124795A1
公开(公告)日：2005-06-09
申请号：US10661378
申请日：2003-09-12
Applicant: Adrienne Dubin , Mark Erlander , Arne Huvar , Rene Huvar , Lukas Buehler
Inventor： Adrienne Dubin , Mark Erlander , Arne Huvar , Rene Huvar , Lukas Buehler
IPC: G01N33/50 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/08 , A61P1/10 , A61P3/04 , A61P3/10 , A61P9/06 , A61P9/12 , A61P9/14 , A61P11/06 , A61P11/08 , A61P13/10 , A61P15/10 , A61P25/04 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P37/08 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/566 , A61K39/395 , C07H21/04
CPC classification number: C07K14/70571 , A61K38/00 , C07K16/286
Abstract: DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征编码人5-HT3-C的DNA。 重组蛋白能够形成生物活性的人5-HT3-C蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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29.发明授权公开(公告)号：US06855560B1
公开(公告)日：2005-02-15
申请号：US09642852
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC: C07K14/72 , C12N15/12 , G01N33/53 , G01N33/567
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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