Process for preparing mitomycin analogs
    22.
    发明授权
    Process for preparing mitomycin analogs 失效
    丝裂霉素类似物的制备方法

    公开(公告)号:US4814445A

    公开(公告)日:1989-03-21

    申请号:US160474

    申请日:1988-02-25

    IPC分类号: C07D487/14

    CPC分类号: C07D487/14

    摘要: The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group. Mitomycin A is an antibiotic of established utility, and the 7-O-substituted mitosane analogs thereof have similar utility.

    摘要翻译: 本发明提供了含有二硫键的新型丝裂霉素类似物及其制备方法。 这些化合物是丝氨酸霉素A类似物,其中7-烷氧基带有结合二硫基的有机取代基。 丝裂霉素A是具有实用性的抗生素,其中7-O-取代的线粒体类似物具有相似的效用。

    Isoxazoline intermediates
    23.
    发明授权
    Isoxazoline intermediates 失效
    异恶唑啉中间体

    公开(公告)号:US4767863A

    公开(公告)日:1988-08-30

    申请号:US66289

    申请日:1987-06-25

    CPC分类号: C07D321/06 C07D261/04

    摘要: New and more efficient chemical processes are provided for preparing (.alpha.S, 5S)-.alpha.-amino-3-chloro-2-isoxazoline-5-acetic acid (AT-125), (.alpha.S, 5S)-.alpha.-amino-3-bromo-2-isoxazoline-5-acetic acid (bromo AT-125) and the C-5 epimers thereof. The disclosed processes allow the above-mentioned antitumor agents to be produced in high yield and purity with substantially fewer steps than prior art chemical procedures.

    摘要翻译: 提供新的和更有效的化学方法用于制备(α,5S)-α-氨基-3-氯-2-异恶唑啉-5-乙酸(AT-125),(αS,5S)-α-氨基 - 3-溴-2-异恶唑啉-5-乙酸(溴AT-125)及其C-5差向异构体。 所公开的方法允许以比现有技术化学方法更少的步骤以高产率和纯度生产上述抗肿瘤剂。

    Trichloroethanimidic acid esters
    24.
    发明授权
    Trichloroethanimidic acid esters 失效
    三氯乙酰亚胺酸酯

    公开(公告)号:US4692538A

    公开(公告)日:1987-09-08

    申请号:US737752

    申请日:1985-05-28

    CPC分类号: C07D261/04 C07D321/06

    摘要: New and more efficient chemical processes are provided for preparing (.alpha.S, 5S)-.alpha.-amino-3-chloro-2-isoxazoline-5-acetic acid (AT-125), (.alpha.S, 5S)-.alpha.-amino-3-bromo-2-isoxazoline-5-acetic acid (bromo AT-125) and the C-5 epimers thereof. The disclosed processes allow the above-mentioned antitumor agents to be produced in high yield and purity with substantially fewer steps than prior art chemical procedures.

    摘要翻译: 提供新的和更有效的化学方法用于制备(α,5S)-α-氨基-3-氯-2-异恶唑啉-5-乙酸(AT-125),(αS,5S)-α-氨基 - 3-溴-2-异恶唑啉-5-乙酸(溴AT-125)及其C-5差向异构体。 所公开的方法允许以比现有技术化学方法更少的步骤以高产率和纯度生产上述抗肿瘤剂。

    Amino disulfides
    25.
    发明授权
    Amino disulfides 失效
    氨基二硫化物

    公开(公告)号:US4691023A

    公开(公告)日:1987-09-01

    申请号:US894602

    申请日:1986-08-07

    IPC分类号: C07D487/14

    CPC分类号: C07D487/14

    摘要: The present invention refers to mitomycin analogs containing a disulfide group. These compounds are mitomycin C derivatives in which the 7-amino group bears an organic substituent incorporating a disulfide group. The compounds are inhibitors of experimental animal tumors.

    摘要翻译: 本发明涉及含有二硫基的丝裂霉素类似物。 这些化合物是丝氨酸霉素C衍生物,其中7-氨基具有结合二硫基的有机取代基。 这些化合物是实验动物肿瘤的抑制剂。

    Amidines
    26.
    发明授权
    Amidines 失效

    公开(公告)号:US4487769A

    公开(公告)日:1984-12-11

    申请号:US492903

    申请日:1983-05-09

    CPC分类号: C07D487/14

    摘要: Mitomycin A, mitomycin C, and porfiromycin react with amide acetals and other amide derivatives to produce amidine derivatives having antitumor activity against experimental animal tumors. The amidines derived from mitomycin C are useful intermediates in reactions with primary amines to produce both known and novel 7-amino-9a-methoxymitosanes having antitumor activity against experimental animal tumors.

    摘要翻译: 丝裂霉素A,丝裂霉素C和卟吩霉素与酰胺缩醛和其它酰胺衍生物反应以产生对实验动物肿瘤具有抗肿瘤活性的脒衍生物。 衍生自丝裂霉素C的脒是与伯胺反应的有用的中间体,以产生对实验动物肿瘤具有抗肿瘤活性的已知和新型的7-氨基-9a-甲氧基异氰酸酯。

    Amino disulfide thiol exchange products
    30.
    发明授权
    Amino disulfide thiol exchange products 失效
    氨基二硫醇硫醇交换产物

    公开(公告)号:US4866180A

    公开(公告)日:1989-09-12

    申请号:US781076

    申请日:1985-09-23

    IPC分类号: C07D487/14

    CPC分类号: C07D487/14

    摘要: This invention refers to 7-amino mitosane analogs (mitomycin C) in which the 7-amino group bears an organic substituent incorporating a disulfide group and to a novel thiol exchange process for producing these compounds. The compounds are inhibitors of experimental animal tumors.

    摘要翻译: 本发明涉及其中7-氨基具有结合二硫键的有机取代基的7-氨基丝裂霉素类似物(丝裂霉素C)和用于制备这些化合物的新型巯基交换方法。 这些化合物是实验动物肿瘤的抑制剂。