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公开(公告)号：US20060040941A1
公开(公告)日：2006-02-23
申请号：US10513116
申请日：2003-04-22
申请人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04 , C07D253/07 , C07D401/12 , C07D403/12
摘要： The invention relates to novel 7-amino-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译： 本发明涉及新型7-氨基 - 咪唑并三嗪酮，其制备方法及其在药物中的应用， 用于治疗和/或预防炎症过程和/或免疫疾病。
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公开(公告)号：US20140045802A1
公开(公告)日：2014-02-13
申请号：US13612435
申请日：2012-09-12
申请人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
发明人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
IPC分类号： C07D239/22 , A61K31/5377 , C07D409/12 , C07D403/06 , C07D401/06 , A61K31/519 , C07D487/04 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D405/12 , A61K45/06 , C07D413/06 , C07D417/12 , A61K31/513
CPC分类号： C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译： 本发明涉及新的4-（4-氰基-2-硫代芳基）二氢嘧啶-2-酮衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺和心血管系统疾病。
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23.发明申请Substituted Arylimidazolone and Triazolone as Inhibitors of Vasopressin Receptors 有权取代的芳基咪唑酮和三唑酮作为加压素受体的抑制剂公开(公告)号：US20090312381A1
公开(公告)日：2009-12-17
申请号：US12301616
申请日：2007-05-21
申请人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
发明人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
IPC分类号： A61K31/4196 , C07D249/12 , C07D233/70 , C07D409/04 , A61K31/4164 , A61P9/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病 以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
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24.发明授权Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD 有权三氮唑和四唑嘧啶衍生物作为治疗COPD的HNE抑制剂公开(公告)号：US08569314B2
公开(公告)日：2013-10-29
申请号：US13143323
申请日：2009-12-29
申请人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig
发明人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D487/14
摘要： The present invention relates to novel heterocyclically fused diaryldihydropyrimidine derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译： 本发明涉及新颖的杂环稠合二芳基二氢嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防肺和心血管系统疾病。
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25.发明申请SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF 有权磺酰胺和硫代咪唑基二异丙基二咪唑啉酮及其用途公开(公告)号：US20120094968A1
公开(公告)日：2012-04-19
申请号：US13262159
申请日：2010-03-30
申请人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Dirk Schneider
发明人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Dirk Schneider
IPC分类号： A61K31/56 , A61K31/513 , C07D413/12 , A61K31/5377 , C07D403/12 , A61P43/00 , C07D471/04 , C07D417/12 , C07D405/12 , A61P9/12 , A61P11/00 , C07D239/22 , C07D401/12
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04
摘要： The present application relates to novel sulfonamidw- or sulfoximine-substituted 1,4-diaryldihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译： 本申请涉及新的磺酰胺基或亚磺酰亚胺取代的1,4-二芳基二氢嘧啶-2-酮衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病以及其用途 用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺和心血管系统疾病。
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26.发明申请5-ethyl-imidazo (5,1-F) (1,2,4,) triazin-4 (3h)-ones as phosphodiesterase inhibitors 审中-公开作为磷酸二酯酶抑制剂的5-乙基咪唑并（5,1-F）（1,2,4）三嗪-4（3h） - 酮公开(公告)号：US20050272732A1
公开(公告)日：2005-12-08
申请号：US10513115
申请日：2003-04-22
申请人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
IPC分类号： C07D253/06 , A61K31/53 , A61P11/00 , A61P11/06 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译： 本发明涉及新的5-乙基 - 咪唑并三嗪酮，其制备方法及其在药物中的用途， 用于治疗和/或预防炎症过程和/或免疫疾病。
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公开(公告)号：US08318761B2
公开(公告)日：2012-11-27
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A01N43/40 , A61K31/435 , A61K31/44
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译： 本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。
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公开(公告)号：US08288402B2
公开(公告)日：2012-10-16
申请号：US12809781
申请日：2008-12-09
申请人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
发明人： Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译： 本发明涉及新的4-（4-氰基-2-硫代芳基）二氢嘧啶-2-酮衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺和心血管系统疾病。
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29.发明授权Substituted arylimidazolone and triazolone as inhibitors of vasopressin receptors 有权取代的芳基咪唑啉酮和三唑酮作为加压素受体的抑制剂公开(公告)号：US08084481B2
公开(公告)日：2011-12-27
申请号：US12301616
申请日：2007-05-21
申请人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
发明人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
IPC分类号： A61K31/41 , A61K31/415 , C07D249/00 , C07D233/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病 以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20090176842A1
公开(公告)日：2009-07-09
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A61K31/4439 , C07D413/04 , C07D213/73 , A61P31/12
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译： 本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。
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