公开(公告)号：US09072832B2

公开(公告)日：2015-07-07

申请号：US14262634

申请日：2014-04-25

Applicant: Medtronic, Inc.

Inventor： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

IPC: A61N1/36 ,  A61M5/172 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/00

CPC classification number: A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

Abstract translation: 装置和方法检测与神经系统疾病的神经系统事件如癫痫发作相关联的检测簇，以及与治疗疗法相关联的更新治疗参数。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

公开(公告)号：US20140276186A1

公开(公告)日：2014-09-18

申请号：US13862238

申请日：2013-04-12

Applicant: MEDTRONIC, INC.

Inventor： Scott R. Stanslaski ,  David L. Carlson ,  Peng Cong ,  Timothy J. Denison ,  David E. Linde ,  Randy M. Jensen

IPC: A61B5/00 ,  A61B5/048

CPC classification number: A61B5/7225 ,  A61B5/04004 ,  A61B5/04012 ,  A61B5/0428 ,  A61B5/048 ,  A61B5/0496 ,  A61B5/7217 ,  A61N1/36125 ,  A61N1/3702 ,  A61N1/3704 ,  H03F3/38 ,  H03F2200/261

Abstract: This disclosure describes techniques for controlling spectral aggressors in a sensing device that uses a chopper amplifier to amplify an input signal prior to sampling the signal. In some examples, the techniques for controlling spectral aggressors may include generating a chopper-stabilized amplified version of an input signal based on a chopper frequency, sampling the chopper-stabilized amplified version of the input signal at a sampling rate to generate a sampled signal, and analyzing a target frequency band of the sampled signal. The chopper frequency and the sampling rate may cause spectral interference that is generated due to the chopper frequency to occur in the sampled signal at one or more frequencies that are outside of the target frequency band of the sampled signal. The techniques for controlling spectral aggressors may reduce the noise caused by the chopper frequency in the resulting sampled signal, thereby improving the quality of the signal.

Abstract translation: 本公开描述了用于控制感测装置中的光谱侵略者的技术，其在采样信号之前使用斩波放大器放大输入信号。 在一些示例中，用于控制频谱侵略者的技术可以包括基于斩波频率产生输入信号的斩波稳定放大版本，以采样率对输入信号的斩波稳定放大版本进行采样以产生采样信号， 并分析采样信号的目标频带。 斩波频率和采样率可能导致由于斩波频率在采样信号中在采样信号的目标频带之外的一个或多个频率处发生的频谱干扰。 用于控制频谱侵入者的技术可以减少由所得到的采样信号中的斩波频率引起的噪声，从而提高信号的质量。

公开(公告)号：US20140135869A1

公开(公告)日：2014-05-15

申请号：US14161363

申请日：2014-01-22

Applicant: Medtronic, Inc.

Inventor： David L. Carlson ,  Randy M. Jensen ,  Timothy J. Denison ,  Jianping Wu ,  Gabriela C. Molnar ,  Scott R. Stanslaski ,  William J. Marks, JR.

IPC: A61N1/36

CPC classification number: A61N1/36067 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/37247

Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。 在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。 也可以使用其他频带特性来选择刺激电极组合。