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    Assessing cognitive disorders based on non-motor epileptiform bioelectrical brain activity
    21.
    发明授权
    Assessing cognitive disorders based on non-motor epileptiform bioelectrical brain activity 有权
    基于非运动性癫痫样生物电脑大脑活动评估认知障碍

    公开(公告)号：US08918176B2

    公开(公告)日：2014-12-23

    申请号：US13777091

    申请日：2013-02-26

    Applicant: Medtronic, Inc.

    Inventor： Dwight E. Nelson ,  Jonathon E. Giftakis

    IPC: A61N1/36 ,  A61B5/00

    CPC classification number: A61N1/36139 ,  A61B5/4052 ,  A61B5/4088 ,  A61B5/4094 ,  A61B5/4842 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082

    Abstract: Various embodiments concern assessing a degenerative cognitive disorder of a patient based on a plurality of episodes of non-motor epileptiform bioelectrical activity. The non-motor epileptiform bioelectrical activity can be detected from one or more bioelectrical brain signals. A worsening cognitive disorder may be indicated by an increase in one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. A therapy can be delivered to reduce one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. The delivery of the therapy can be controlled based on the plurality of episodes of non-motor epileptiform bioelectrical activity.

    Abstract translation: 各种实施方案涉及基于多次发作的非运动性癫痫样生物电活性来评估患者的退行性认知障碍。 可以从一个或多个生物电脑信号检测非运动性癫痫样生物电活动。 恶化的认知障碍可以通过非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种的增加来表示。 可以递送治疗以减少非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种。 可以基于多次非运动性癫痫样生物电活动来控制治疗的递送。

    Clustering of Recorded Patient Neurological Activity to Determine Length of a Neurological Event
    22.
    发明申请
    Clustering of Recorded Patient Neurological Activity to Determine Length of a Neurological Event 有权
    记录患者神经活动以确定神经事件长度的聚类

    公开(公告)号：US20140309614A1

    公开(公告)日：2014-10-16

    申请号：US14262634

    申请日：2014-04-25

    Applicant: Medtronic, Inc.

    Inventor： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC: A61M5/172 ,  A61N1/36

    CPC classification number: A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

    Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    Abstract translation: 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

    BRAIN STIMULATION RESPONSE PROFILING
    24.
    发明申请
    BRAIN STIMULATION RESPONSE PROFILING 有权
    脑刺激反应概况

    公开(公告)号：US20140180358A1

    公开(公告)日：2014-06-26

    申请号：US14194026

    申请日：2014-02-28

    Applicant: MEDTRONIC, INC.

    Inventor： Jonathon E. Giftakis ,  Paul H. Stypulkowski ,  Timothy J. Denison ,  Scott R. Stanslaski

    IPC: A61N1/36

    CPC classification number: A61N1/36146 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/372

    Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.

    Abstract translation: 各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。 刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。 刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。 刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。 提出海马刺激的数据表明抑制窗口。

    BRAIN STIMULATION RESPONSE PROFILING
    26.
    发明申请
    BRAIN STIMULATION RESPONSE PROFILING 有权
    脑刺激反应概况

    公开(公告)号：US20130218232A1

    公开(公告)日：2013-08-22

    申请号：US13766006

    申请日：2013-02-13

    Applicant: Medtronic, Inc.

    Inventor： Jonathon E. Giftakis ,  Paul H. Stypulkowski ,  Timothy J. Denison ,  Scott R. Stanslaski

    IPC: A61N1/372

    CPC classification number: A61N1/36146 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/372

    Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.

    Abstract translation: 各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。 刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。 刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。 刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。 提出海马刺激的数据表明抑制窗口。

    Target therapy delivery site selection
    30.
    发明授权
    Target therapy delivery site selection 有权

    公开(公告)号：US10252055B2

    公开(公告)日：2019-04-09

    申请号：US14207926

    申请日：2014-03-13

    Applicant: Medtronic, Inc.

    Inventor： Paul H. Stypulkowski ,  Jonathon E. Giftakis

    IPC: A61N1/05 ,  A61N1/36

    Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.

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