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21.发明授权System and method for providing depth of interaction detection using positron emission tomography 有权使用正电子发射断层扫描提供相互作用检测深度的系统和方法公开(公告)号：US09513387B2
公开(公告)日：2016-12-06
申请号：US13017617
申请日：2011-01-31
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1644 , G01T1/2002 , G01T1/2008
摘要： A system and method is provided for determining depth of interaction (DOI) information. The system and method includes a detector configured to generate DOI information as a result of radiation emitted from a radiation source. The system and method further includes a plurality of scintillator pixels forming a block, wherein the plurality of scintillator pixels have a first portion and a second portion. A first medium distributed in an alternating pattern of coupling and separation between each of the scintillator pixels in a first portion or second portion of the block is also provided. A plurality of sensors for detecting scintillation events across the plurality of scintillators based on the alternating pattern of coupling and separation between each of the scintillator pixels, wherein DOI information is provided by a position profile of the block, and an image processor for generating a 3 dimensional image from the DOI information are also included.
摘要翻译： 提供了用于确定交互深度（DOI）信息的系统和方法。 该系统和方法包括检测器，被配置为产生作为辐射源发射的辐射的结果的DOI信息。 该系统和方法还包括形成块的多个闪烁体像素，其中多个闪烁体像素具有第一部分和第二部分。 还提供了分布在块的第一部分或第二部分中的每个闪烁体像素之间的耦合和分离的交替模式的第一介质。 多个传感器，用于基于每个闪烁体像素之间的耦合和分离的交替模式来检测跨多个闪烁体的闪烁事件，其中DOI信息由块的位置分布提供，以及用于产生3的闪烁体的图像处理器 还包括来自DOI信息的三维图像。
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公开(公告)号：US20130032722A1
公开(公告)日：2013-02-07
申请号：US13426667
申请日：2012-03-22
CPC分类号： G01T1/20 , G01T1/22 , G01T1/2978
摘要： A device for detecting ionizing radiation includes a radiation interaction region configured to generate light in response to an interaction with the ionizing radiation, an optical gain medium region in optical communication with the radiation interaction region and configured to amplify the light, and an energy source coupled to the optical gain medium region and configured to maintain a state of population inversion in the optical gain medium region. The optical gain medium region has an emission wavelength that corresponds with a wavelength of the light generated by the radiation interaction region.
摘要翻译： 用于检测电离辐射的装置包括被配置为响应于与电离辐射的相互作用而产生光的辐射相互作用区域，与辐射相互作用区域光学通信并被配置为放大光的光学增益介质区域，以及耦合的能量源 并且被配置为保持光学增益介质区域中的总体反转状态。 光学增益介质区域具有与由辐射相互作用区域产生的光的波长相对应的发射波长。
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23.发明申请High Density, Proportional-Mode, APD Arrays for Individual Scintillator Readout in PET Applications 有权高密度，比例模式，APD阵列用于PET应用中的单个闪烁读出公开(公告)号：US20120112083A1
公开(公告)日：2012-05-10
申请号：US12943164
申请日：2010-11-10
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , A61B6/037
摘要： The present invention is a photodetector including improved photosensors configured of an array of small (sub-millimeter) high-density avalanche photodiode cells utilized to readout a single scintillator. Each photosensor comprises a plurality of avalanche photodiodes cells arranged in an (n×n) array of avalanche photodiode cells (where, n>1) that are coupled to a single scintillation crystal. The overall (n×n) array area as the photosensor is the same as the area of a face of the scintillator and each avalanche photodiode cell has a surface area that is not greater than one square millimeter. The photosensor is also configured to facilitate reading the output of each avalanche photodiode cell in the array. By reading out each small avalanche photodiode cell independently, the noise and capacitance are minimized and thereby provide a more accurate determination of energy and timing.
摘要翻译： 本发明是一种光电检测器，其包括由用于读出单个闪烁体的小（亚毫米）高密度雪崩光电二极管阵列的阵列构成的改进的光电传感器。 每个光传感器包括以与单个闪烁晶体耦合的雪崩光电二极管单元（其中，n> 1）的（n×n）阵列排列的多个雪崩光电二极管单元。 作为光传感器的整体（n×n）阵列区域与闪烁体的面的面积相同，并且每个雪崩光电二极管单元的表面积不大于1平方毫米。 光传感器还被配置为便于读取阵列中每个雪崩光电二极管单元的输出。 通过独立地读出每个小雪崩光电二极管单元，噪声和电容被最小化，从而提供更准确的能量和时间的确定。
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24.发明授权Apparatus and method for image alignment for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) scanner 有权用于组合正电子发射断层扫描（PET）和磁共振成像（MRI）扫描仪的图像对准的装置和方法公开(公告)号：US07768261B2
公开(公告)日：2010-08-03
申请号：US12109605
申请日：2008-04-25
申请人： Rainer Paul , Matthias J. Schmand , Charles H. Hayden, Jr. , James Corbeil , Christian J. Michel , Ziad Burbar , Volker Matschl
发明人： Rainer Paul , Matthias J. Schmand , Charles H. Hayden, Jr. , James Corbeil , Christian J. Michel , Ziad Burbar , Volker Matschl
IPC分类号： G01V3/00
CPC分类号： G01R33/481 , A61B6/037 , A61B6/583 , G01R33/58 , G01T1/1603
摘要： A phantom and method are provided for co-registering a magnetic resonance image and a nuclear medical image. The phantom includes a first housing defining a first chamber configured to receive a magnetic resonance material upon which magnetic resonance imaging can be performed in order to produce the magnetic resonance image. The phantom also includes three or more second housings configured to be attached to the first housing, where the second housings each define a second chamber configured to receive a radioactive material upon which nuclear imaging can be performed in order to produce the nuclear medical image and upon which the magnetic imaging can be performed in order to produce the magnetic resonance image. The first chamber has a volumetric capacity that is larger than a volumetric capacity of each second chamber.
摘要翻译： 提供了用于共同配准磁共振图像和核医学图像的体模和方法。 幻影包括限定第一室的第一壳体，其被配置为接收磁共振材料，在该共振材料上可进行磁共振成像以产生磁共振图像。 该幻影还包括构造成附接到第一壳体的三个或更多个第二壳体，其中第二壳体每个限定第二室，所述第二室被构造成接收放射性材料，在该第二室上可以执行核成像以产生核医学图像， 可以进行磁性成像以产生磁共振图像。 第一室具有大于每个第二室的容积的容积。
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25.发明申请Positron Emission Tomography Detector Based on Monolithic Scintillator Crystal 有权基于单片闪烁晶体的正电子发射断层扫描检测器公开(公告)号：US20130009067A1
公开(公告)日：2013-01-10
申请号：US13540674
申请日：2012-07-03
CPC分类号： G01T1/1642 , A61B6/037 , G01T1/1644 , G01T1/2985
摘要： A high-resolution nuclear imaging detector for use in systems such as positron emission tomography includes a monolithic scintillator crystal block in combination with a single photomultiplier tube read-out channel for timing and total energy signals, and one or more solid-state photosensor pixels arrays on one or more vertical surfaces of the scintillator block to determine event position information.
摘要翻译： 用于诸如正电子发射断层摄影系统的高分辨率核成像检测器包括与用于定时和总能量信号的单个光电倍增管读出通道组合的单片闪烁体晶体块和一个或多个固态光电传感器像素阵列 在闪烁体块的一个或多个垂直表面上，以确定事件位置信息。
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26.发明申请System and Method for Providing Depth of Interaction Detection Using Positron Emission Tomography 有权使用正电子发射断层扫描提供相互作用检测深度的系统和方法公开(公告)号：US20110192982A1
公开(公告)日：2011-08-11
申请号：US13017617
申请日：2011-01-31
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1644 , G01T1/2002 , G01T1/2008
摘要： A system and method is provided for determining depth of interaction (DOI) information. The system and method includes a detector configured to generate DOI information as a result of radiation emitted from a radiation source. The system and method further includes a plurality of scintillator pixels forming a block, wherein the plurality of scintillator pixels have a first portion and a second portion. A first medium distributed in an alternating pattern of coupling and separation between each of the scintillator pixels in a first portion or second portion of the block is also provided. A plurality of sensors for detecting scintillation events across the plurality of scintillators based on the alternating pattern of coupling and separation between each of the scintillator pixels, wherein DOI information is provided by a position profile of the block, and an image processor for generating a 3 dimensional image from the DOI information are also included.
摘要翻译： 提供了用于确定交互深度（DOI）信息的系统和方法。 该系统和方法包括检测器，被配置为产生作为辐射源发射的辐射的结果的DOI信息。 该系统和方法还包括形成块的多个闪烁体像素，其中多个闪烁体像素具有第一部分和第二部分。 还提供了分布在块的第一部分或第二部分中的每个闪烁体像素之间的耦合和分离的交替模式的第一介质。 多个传感器，用于基于每个闪烁体像素之间的耦合和分离的交替模式来检测跨多个闪烁体的闪烁事件，其中DOI信息由块的位置分布提供，以及用于产生3的闪烁体的图像处理器 还包括来自DOI信息的三维图像。
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公开(公告)号：US20110074426A1
公开(公告)日：2011-03-31
申请号：US12585867
申请日：2009-09-28
申请人： Matthias J. Schmand , Markus Vester , Nan Zhang
发明人： Matthias J. Schmand , Markus Vester , Nan Zhang
CPC分类号： A61B6/4411 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B6/4417 , G01R33/481 , G01T1/1603 , G01T1/1644
摘要： An emission tomography detector module and an emission tomography scanner are disclosed. In at least one embodiment, the emission tomography detector modules includes a scintillator to capture an photon, the scintillator emitting a scintillating light on capturing the photon; a first type of solid-state photodetector to detect the scintillating light; and a second type of solid-state photodetector to detect the scintillating light, wherein the first type of solid-state photodetector and the second type of solid-state photodetector are different with respect to a detecting property.
摘要翻译： 公开了一种发射断层摄影检测器模块和发射断层扫描仪。 在至少一个实施例中，发射断层摄影检测器模块包括闪光体以捕获光子，闪烁体在捕获光子时发射闪烁光; 用于检测闪烁光的第一种类型的固态光电检测器; 以及用于检测闪烁光的第二类型的固态光电检测器，其中所述第一类型的固态光电检测器和所述第二类型的固态光电检测器相对于检测特性是不同的。
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28.发明申请公开(公告)号：US20100066426A1
公开(公告)日：2010-03-18
申请号：US12558007
申请日：2009-09-11
申请人： Matthias J. Schmand , Nan Zhang
发明人： Matthias J. Schmand , Nan Zhang
IPC分类号： H03L5/00
CPC分类号： G01T1/248
摘要： A simple, low cost circuit with only passive components, and thus low power consumption, is provided for baseline restoration of an AC coupled signal. The circuit includes a passive network of diodes arranged in a star configuration and an RF-transformer. A differential signal strategy may be employed by including a differential amplifier at the input and output of the passive network.
摘要翻译： 提供了一种简单的低成本电路，仅具有无源组件，因此具有低功耗，用于AC耦合信号的基线恢复。 该电路包括以星形结构布置的二极管的无源网络和RF变压器。 可以通过在无源网络的输入和输出处包括差分放大器来采用差分信号策略。
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29.发明申请Real-Time Gain Compensation for Photo Detectors Based on Energy Peak Detection 有权基于能量峰值检测的光电探测器实时增益补偿公开(公告)号：US20100065723A1
公开(公告)日：2010-03-18
申请号：US12561204
申请日：2009-09-16
申请人： Ziad Burbar , Dongming Hu , Matthias J. Schmand
发明人： Ziad Burbar , Dongming Hu , Matthias J. Schmand
IPC分类号： H03G3/20
CPC分类号： G01T1/1648
摘要： A method, process and apparatus for compensating for changes to the gain of photo detectors in a nuclear imaging apparatus is disclosed. Specifically, embodiments detect positron annihilation event pulses using photo detectors. Changes to the gain of the photo detectors are compensated for by determining the relationship of a detected event pulse peak with a target event pulse peak. Based on the difference between these two peaks, a corrected gain is determined in a closed-loop control system. The corrected gain can be used to compensate for temperature changes that can affect the gain of the photo detectors.
摘要翻译： 公开了一种用于补偿核成像装置中光检测器的增益变化的方法，过程和装置。 具体地，实施例使用光电检测器检测正电子湮灭事件脉冲。 通过确定检测到的事件脉冲峰值与目标事件脉冲峰值的关系来补偿光电检测器增益的变化。 基于这两个峰之间的差异，在闭环控制系统中确定校正增益。 校正的增益可用于补偿可影响光电检测器增益的温度变化。
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公开(公告)号：US20090114827A1
公开(公告)日：2009-05-07
申请号：US12232451
申请日：2008-09-17
申请人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew E. Martin , Matthias J. Schmand
发明人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew E. Martin , Matthias J. Schmand
CPC分类号： G01T1/1603 , A61B6/037 , G01T7/005
摘要： A method is disclosed for stabilizing the gain of a PET detection system with a cooling unit. The method includes determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.
摘要翻译： 公开了一种用于通过冷却单元稳定PET检测系统的增益的方法。 该方法包括确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度，使得增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。
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