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21.发明授权Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose 失效制备4,1'，6'-三氯-4,1'，6'-三脱氧半乳糖蔗糖的方法
公开(公告)号：US4362869A
公开(公告)日：1982-12-07
申请号：US212898
申请日：1980-12-04
CPC分类号： C07H5/02
摘要： 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose is prepared by a process including the steps of:(a) isomerizing 2,3,4,3',4'-penta-O-acetyl sucrose to 2,3,6,3',4'-penta-O-acetyl sucrose;(b) chlorinating the isomerized acetate at the 4,1' and 6'-positions; and(c) deacetylating the resulting chlorinated product; the isomerization step (a) being effected by treating a solution of 2,3,4,3',4'-penta-O-acetyl sucrose in an inert solvent with a weak acid at an elevated temperature.
摘要翻译： 通过包括以下步骤的方法制备4,1'，6'-三氯-4,1'，6'-三脱氧半乳糖蔗糖：（a）异构化2,3,4,3'，4'-五-O-乙酰基 蔗糖至2,3,6,3'，4'-五-O-乙酰基蔗糖; （b）在4,1'和6'位置氯化异构化的乙酸酯; 和（c）使得到的氯化产物脱乙酰化; 异构化步骤（a）通过在惰性溶剂中用弱酸在升高的温度下处理2,3,4,3'，4'-五-O-乙酰基蔗糖的溶液来进行。
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公开(公告)号：US4051276A
公开(公告)日：1977-09-27
申请号：US660286
申请日：1976-02-23
摘要： This invention relates to solutions of selected organo-metallic compounds ssolved in an organic solvent which are useful for deacidifying a cellulose fiber paper. The paper is treated by means well known in the art, such as dipping or spraying. The organo-metallic compounds useful in this invention are compounds which may be rapidly hydrolyzed to an alkaline material such as lower alkyl compounds of lithium, aluminum, magnesium, gallium, zinc, and mixtures of these compounds. The organic solvent is a liquid which will not react with the organo-metallic compound, dissolve inks, or cause discoloration of other materials usually found in and around printed matter. After the paper is impregnated with the solution the organo-metallic compound remaining on the paper is hydrolyzed to an alkaline material.
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23.发明授权Meditopes and related meditope-monoclonal antibody delivery systems, synthesis and therapeutic uses thereof 有权凝胶剂和相关的药物 - 单克隆抗体递送系统，其合成和治疗用途公开(公告)号：US08658774B2
公开(公告)日：2014-02-25
申请号：US13270207
申请日：2011-10-10
申请人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang
CPC分类号： C07K16/2863 , A61K47/66 , A61K47/6851 , A61K47/6897 , B82Y5/00 , C07K7/64 , C07K16/32 , C07K16/44 , C07K2317/34 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/30
摘要： Meditope variants and methods for their use are provided herein. A meditope variant as described herein comprises a peptide having a sequence CQFDLSTRRLKC (SEQ ID NO:1) or CQYNLSSRALKC (SEQ ID NO:2) that has one or more modifications at of least one amino acid residue of the sequence. Multivalent meditope variant tethering entities are also provided. Such entities may include two or more meditopes coupled via a long linker, multivalent scaffold, biotin-streptavidin, or IgG Fc domain. Further, methods of treating, imaging or diagnosing a disease or condition are provided. Such methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, the pharmaceutical compound comprising an antibody-meditope complex; a multivalent tethering agent in combination with a monoclonal antibody or functional fragment thereof; or a combination thereof.
摘要翻译： 本文提供了Meditope变体及其使用方法。 如本文所述的本发明变体包含在序列的至少一个氨基酸残基上具有一个或多个修饰的具有序列CQFDLSTRRLKC（SEQ ID NO：1）或CQYNLSSRALKC（SEQ ID NO：2）的肽。 还提供了多重测井变体tethering实体。 这样的实体可以包括通过长连接子，多价支架，生物素 - 链亲和素或IgG Fc结构域偶联的两个或更多个中枢。 此外，提供了治疗，成像或诊断疾病或病症的方法。 这样的方法可以包括向受试者施用治疗有效量的药物组合物，所述药物化合物包含抗体 - 中间体复合物; 多价连结剂与单克隆抗体或其功能片段组合; 或其组合。
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24.发明申请DESIGN AND DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS; APPLICATION TO ANTI-EGFR ANTIBODIES 有权掩蔽性治疗抗体的设计和开发限制非目标效应; 应用于抗EGFR抗体公开(公告)号：US20130150558A1
公开(公告)日：2013-06-13
申请号：US13542805
申请日：2012-07-06
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K16/30 , C07K16/32 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/50
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.
摘要翻译： 在一个实施方案中，提供了掩蔽的单克隆抗体（mAb），由核酸序列或包含信号序列，掩蔽表位序列的氨基酸序列分子编码的mAb，可通过蛋白酶特异性的蛋白酶切割的接头序列 目标组织; 和抗体或其功能片段。 在另一个实施方案中，提供了跨屏蔽的mAb异二聚体复合物，其包含第一掩蔽的mAb，其包含第一信号序列，第一掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第一接头， 抗体或其片段; 和第二掩蔽的mAb，其包含第二信号序列，第二掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第二接头和第二抗体或其片段。
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公开(公告)号：US20120301400A1
公开(公告)日：2012-11-29
申请号：US13443804
申请日：2012-04-10
申请人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
CPC分类号： A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
摘要翻译： 提供了与抗体结合的抗体和沉默剂，以及包含中间体和抗体的复合物，组合物和组合，以及生产，使用，测试和筛选其中的方法，包括治疗和诊断方法和用途。
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公开(公告)号：US5689663A
公开(公告)日：1997-11-18
申请号：US472052
申请日：1995-06-06
申请人： John C. Williams
发明人： John C. Williams
CPC分类号： G06F17/30017 , G06F3/0481 , Y10S715/97
摘要： A remote controller user interface for accessing information within a computer system. The remote controller contains a window display area for displaying pictorial, graphical and textual information, and a button bank area for controlling the information displayed within the window display area. In a preferred embodiment, the remote controller is generated by a computer program which permits the user to access information about movies. By selecting the appropriate button of the remote controller, various information is displayed within the window display area of the remote controller, as well as upon the screen of the computer system display device. By use of the remote controller, users with little or no prior computer experience are confronted with a recognizable user interface which permits easy access to information.
摘要翻译： 用于访问计算机系统内的信息的遥控器用户界面。 遥控器包括用于显示图形，图形和文本信息的窗口显示区域，以及用于控制在窗口显示区域内显示的信息的按钮区域区域。 在优选实施例中，遥控器由允许用户访问有关电影的信息的计算机程序产生。 通过选择遥控器的适当按钮，在遥控器的窗口显示区域以及计算机系统显示设备的屏幕上显示各种信息。 通过使用遥控器，具有很少或没有先前计算机体验的用户面对可识别的用户界面，其允许容易地访问信息。
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公开(公告)号：US4687445A
公开(公告)日：1987-08-18
申请号：US236244
申请日：1981-02-20
申请人： John C. Williams
发明人： John C. Williams
摘要： A subsurface antenna system including at least one pair of radiating elements and feed system is buried within a subsurface medium. The radiating elements comprising the system are spaced apart at least one quarter free space wavelength at an operating frequency. The radiating elements are spaced from each other and the feed system provides appropriate relative phase to signals at the elements to produce from the antenna system a directional antenna pattern in free space.
摘要翻译： 包括至少一对辐射元件和进料系统的地下天线系统被埋在地下介质内。 包括系统的辐射元件在工作频率处间隔至少四分之一自由空间波长。 辐射元件彼此间隔开，并且馈电系统为在元件处的信号提供适当的相对相位，以从天线系统产生自由空间中的定向天线方向图。
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公开(公告)号：US4173019A
公开(公告)日：1979-10-30
申请号：US874561
申请日：1978-02-02
申请人： John C. Williams
发明人： John C. Williams
CPC分类号： H01Q9/0407 , H01Q13/206 , H01Q21/062
摘要： A microwave antenna comprising a dielectric sheet with a ground conductor on one side and an array of antenna elements on the other side. The elements are connected in shunt by feeder lines which are inclined to the direction of polarization of the antenna. The elements may be fed from a common central feed point. A suitable pattern of feeder lines comprises a plurality of parallel regularly-spaced lines inclined at a given angle to the direction of polarization and intersected by a single feeder line inclined at a mirror-inverted angle to the direction of polarization. The feeder lines are suitably of much higher impedance than the elements. Power tapering across the antenna apertures giving good polar diagrams is readily obtainable with such an arrangement.
摘要翻译： 一种微波天线，包括在一侧具有接地导体的电介质片和另一侧的天线元件阵列。 这些元件通过与天线的偏振方向倾斜的馈线相连。 这些元件可以从公共中心馈电点进给。 馈线的合适图案包括以与偏振方向成给定角度倾斜的多个平行规则间隔的线，并且以与偏振方向成反射镜倾斜的单个馈线相交。 给料线适当地比元件高得多的阻抗。 通过这样的布置，可以容易地获得跨越天线孔径的功率逐渐减小的功率，从而获得良好的极地图。
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公开(公告)号：US08962804B2
公开(公告)日：2015-02-24
申请号：US13443804
申请日：2012-04-10
申请人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
CPC分类号： A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
摘要翻译： 提供了与抗体结合的抗体和沉默剂，以及包含中间体和抗体的复合物，组合物和组合，以及生产，使用，测试和筛选其中的方法，包括治疗和诊断方法和用途。
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30.发明申请DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS: APPLICATION TO ANTI-EGFR ANTIBODIES 审中-公开掩蔽性治疗抗体的开发限制非靶标效应：应用于抗EGFR抗体公开(公告)号：US20110178279A1
公开(公告)日：2011-07-21
申请号：US12849786
申请日：2010-08-03
CPC分类号： C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/32 , C07K2319/50
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.
摘要翻译： 在一个实施方案中，提供了掩蔽的单克隆抗体（mAb），由核酸序列或包含信号序列，掩蔽表位序列的氨基酸序列分子编码的mAb，可通过蛋白酶特异性的蛋白酶切割的接头序列 目标组织; 和抗体或其功能片段。 在另一个实施方案中，提供了跨屏蔽的mAb异二聚体复合物，其包含第一掩蔽的mAb，其包含第一信号序列，第一掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第一接头， 抗体或其片段; 和第二掩蔽的mAb，其包含第二信号序列，第二掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第二接头和第二抗体或其片段。
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