公开(公告)号：US20080221158A1

公开(公告)日：2008-09-11

申请号：US10556709

申请日：2004-05-11

申请人： Sulejman Alihodzic ,  Andrea Berdik ,  Richard Lewis Jarvest ,  Gorjana Lazarevski

发明人： Sulejman Alihodzic ,  Andrea Berdik ,  Richard Lewis Jarvest ,  Gorjana Lazarevski

IPC分类号： A61K31/47 ,  C07D267/00 ,  A61P31/00

CPC分类号： C07H17/08

摘要： The present invention relates to 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

摘要翻译： 本发明涉及在式（I）的4“位取代的15元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防人或动物体内全身或局部微生物感染中的用途 身体。

公开(公告)号：US20070185117A1

公开(公告)日：2007-08-09

申请号：US10556645

申请日：2004-05-11

申请人： Sulejman Alihodzic ,  Andrew Forrest ,  Richarl Jarvest ,  Gorjana Lazarevski ,  Drazen Pavlovic

发明人： Sulejman Alihodzic ,  Andrew Forrest ,  Richarl Jarvest ,  Gorjana Lazarevski ,  Drazen Pavlovic

IPC分类号： A61K31/335 ,  A61K31/44 ,  A61K31/495 ,  C07D211/04

CPC分类号： C07H17/08

摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

摘要翻译： 本发明涉及在式（I）的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防全身或局部微生物感染中的用途 人或动物体。

公开(公告)号：US20050080025A1

公开(公告)日：2005-04-14

申请号：US10495413

申请日：2002-11-13

申请人： Suleman Alihodzic ,  Daniele Andretoh ,  Andrea Berdik ,  Ilaria Bientinesi ,  Stefano Biondi ,  Manuela Ciraco ,  Federica Damiani ,  Marko Djerek ,  Miljenko Dumic ,  Vesna Erakovic ,  Antun Hutinec ,  Gorjana Lazarevski ,  Sergio Lociuro ,  Natasa Marsic ,  Zorica Marusic-Istuk ,  Stjepan Mutak ,  Alfred Paio ,  Drazen Pavlovic ,  Anna Quaglia ,  Wolfgang Schoenfeld ,  Vlado Stimac ,  Jessica Tibasco

发明人： Suleman Alihodzic ,  Daniele Andretoh ,  Andrea Berdik ,  Ilaria Bientinesi ,  Stefano Biondi ,  Manuela Ciraco ,  Federica Damiani ,  Marko Djerek ,  Miljenko Dumic ,  Vesna Erakovic ,  Antun Hutinec ,  Gorjana Lazarevski ,  Sergio Lociuro ,  Natasa Marsic ,  Zorica Marusic-Istuk ,  Stjepan Mutak ,  Alfred Paio ,  Drazen Pavlovic ,  Anna Quaglia ,  Wolfgang Schoenfeld ,  Vlado Stimac ,  Jessica Tibasco

IPC分类号： A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7052

CPC分类号： C07H17/08

摘要： The present invention relates to 14 or 15 membered macrolides substituted at the 4th position of formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.

摘要翻译： 本发明涉及在式（I）的第4位取代的14或15元大环内酯类及其药学上可接受的盐和溶剂化物，其制备方法及其在治疗或预防全身或局部细菌感染中的用途 一个人或动物的身体。

公开(公告)号：US06593360B1

公开(公告)日：2003-07-15

申请号：US09959204

申请日：2002-01-22

申请人： Gorjana Lazarevski ,  Sulejman Alihod{haeck over (z)}ić ,  Gabrijela Kobrehel ,  Stjepan Mutak

发明人： Gorjana Lazarevski ,  Sulejman Alihod{haeck over (z)}ić ,  Gabrijela Kobrehel ,  Stjepan Mutak

IPC分类号： C07H1708

CPC分类号： C07H17/08

摘要： The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-O-methyl-erythromycin A of general formula (I) their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, to intermediates for their preparation, to a process for their preparation, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to their hydrates, to a process for the preparation of pharmaceutical compositions as well as to a use of pharmaceutical compositions for the treatment of bacterial infections.

摘要翻译： 本发明涉及由通式（I）的6-O-甲基 - 红霉素A类别的与无机或有机酸及其水合物的药学上可接受的加成盐与其中间体的新型15-元8a-和9-内酰胺， 制备，其制备方法，其与无机或有机酸的药学上可接受的加成盐，其水合物，制备药物组合物的方法以及药物组合物用于治疗细菌感染的用途。

公开(公告)号：US6071886A

公开(公告)日：2000-06-06

申请号：US223978

申请日：1998-12-31

申请人： Nedjeljko Kujundzic ,  Dina Pavlovic ,  Gabrijela Kobrehel ,  Gorjana Lazarevski ,  Zeljko Kelneric

发明人： Nedjeljko Kujundzic ,  Dina Pavlovic ,  Gabrijela Kobrehel ,  Gorjana Lazarevski ,  Zeljko Kelneric

IPC分类号： C07H17/00 ,  A61K31/00 ,  A61K31/04 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention relates to .beta.,.beta.-disubstituted derivatives of 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A, new semisynthetic antibiotics of macrolide class of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are mutually the same or different and represent nitrile, carboxy group of the formula COOR.sup.3, wherein R.sup.3 represents C.sub.1 -C.sub.4 alkyl group, or keto group of the formula COR.sup.4, wherein R.sup.4 represents C.sub.1 -C.sub.4 alkyl group, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for the preparation thereof, to a process for the preparation of pharmaceutical compositions, as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.

摘要翻译： 本发明涉及9-脱氧-9a-N-乙烯基-9a-氮杂-9a-高红霉素A的β，β-二取代衍生物，通式（I）的大环内酯类的新的半合成抗生素，其中R1和R2相互 表示腈，式COOR 3的羧基，其中R 3表示C 1 -C 4烷基，或式COR 4的酮基（其中R 4表示C 1 -C 4烷基）与其药学上可接受的加成盐与无机或 有机酸，其制备方法，制备药物组合物的方法，以及所用药物组合物在细菌感染治疗中的用途。

公开(公告)号：US5434140A

公开(公告)日：1995-07-18

申请号：US178559

申请日：1994-01-07

申请人： Gabrijela Kobrehel ,  Gorjana Lazarevski ,  Slobodan Djokic

发明人： Gabrijela Kobrehel ,  Gorjana Lazarevski ,  Slobodan Djokic

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/00 ,  C07H17/08

CPC分类号： C07H17/08 ,  C07H17/00

摘要： The invention relates to 9-deoxo-9a-aza-11-deoxy-9a-homoerythromycin A 9a,11-cyclic carbamates, novel semisynthetic macrolide antibiotics from the genus of azalides, of the formula (I) ##STR1## whereinR.sup.1 .dbd.R.sup.2 .dbd.CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 .dbd.R.sup.4 .dbd.CH.sub.3, (IA)R.sup.1 .dbd.R.sup.2 .dbd.CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 .dbd.CH.sub.3, R.sup.4 .dbd.H, (IB)R.sup.1 .dbd.R.sup.2 .dbd.CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 .dbd.R.sup.4 .dbd.H, (IC)R.sup.1 .dbd.R.sup.2 .dbd.H, R.sup.3 .dbd.R.sup.4 .dbd.CH.sub.3,(ID)R.sup.1 .dbd.R.sup.2 .dbd.R.sup.4 .dbd.H, R.sup.3 .dbd.CH.sub.3,(IE)R.sup.1 .dbd.R.sup.2 .dbd.R.sup.3 .dbd.R.sup.4 .dbd.H, (IF)R.sup.1 .dbd.H, R.sup.2 .dbd.R.sup.3 .dbd.R.sup.4 .dbd.CH.sub.3,(IG)R.sup.1 .dbd.R.sup.4 .dbd.H, R.sup.2 .dbd.R.sup.3 .dbd.CH.sub.3,(IH)R.sup.1 .dbd.R.sup.3 .dbd.R.sup.4 .dbd.H, R.sup.2 .dbd.CH.sub.3,(IJ)to pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to intermediates and to processes for the preparation thereof, to a process for preparing pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in treatment of bacterial infections.

摘要翻译： 本发明涉及9-脱氧-9a-氮杂-11-脱氧-9a-高红霉素A 9a,11-环状氨基甲酸酯，由式（I）的化合物制备的新的半合成大环内酯类抗生素，其中R1 = R2 = CO 2 CH 2 C 6 H 5，R 3 = R 4 = CH 3，（IA）R 1 = R 2 = CO 2 CH 2 C 6 H 5，R 3 = CH 3，R 4 = H，（IB）R 1 = R 2 = CO 2 CH 2 C 6 H 5， R3 = R4 = CH3，（ID）R1 = R2 = R4 = H，R3 = CH3，（IE）R1 = R2 = R3 = R4 = H，（IF）R1 = H，R2 = R3 = R4 = CH3，（ IG）R1 = R4 = H，R2 = R3 = CH3，（1H）R1 = R3 = R4 = H，R2 = CH3，（IJ）与其与无机或有机酸的药学上可接受的加成盐， 制备药物组合物的方法以及所获得的药物组合物在细菌感染治疗中的用途。