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公开(公告)号:US06900345B2
公开(公告)日:2005-05-31
申请号:US10399023
申请日:2001-10-08
IPC分类号: A61K31/27 , A61K31/34 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/415 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/445 , A61K31/4462 , A61K31/4465 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P31/04 , C07C271/06 , C07C271/66 , C07C311/04 , C07C317/18 , C07C323/12 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/22 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/404 , C07D211/00 , C07D211/42 , C07D211/46 , C07D211/62 , C07D211/76 , C07D213/04 , C07D213/30 , C07D213/40 , C07D213/64 , C07D231/20 , C07D231/22 , C07D239/30 , C07D239/42 , C07D239/48 , C07D239/54 , C07D241/04 , C07D241/24 , C07D261/02 , C07D261/08 , C07D261/12 , C07D263/24 , C07D265/30 , C07D279/12 , C07D295/00 , C07D295/185 , C07D295/26 , C07D307/20 , C07D307/66 , C07D317/10 , C07D317/24 , C07D319/06 , C07D331/04 , C07D333/32 , C07D333/48 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02 , C07D493/04 , C07C26/00
CPC分类号: C07D331/04 , C07C271/66 , C07C2601/10 , C07C2603/82 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/22 , C07D207/26 , C07D207/273 , C07D207/404 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/40 , C07D213/64 , C07D231/22 , C07D239/30 , C07D239/42 , C07D239/49 , C07D239/54 , C07D261/12 , C07D263/24 , C07D265/30 , C07D295/185 , C07D295/26 , C07D307/20 , C07D307/66 , C07D317/10 , C07D319/06 , C07D333/32 , C07D401/06 , C07D493/04
摘要: Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy.
摘要翻译: 具有下列公式的Pleuromutilin化合物:用于抗菌治疗。
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公开(公告)号:US06388074B2
公开(公告)日:2002-05-14
申请号:US09734051
申请日:2000-12-11
IPC分类号: C07D47318
CPC分类号: C07D473/00 , C07C31/22 , C07C43/1782 , C07C69/007 , C07C69/63 , C07D319/06 , C07F9/65616
摘要: The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to form a guanine) or hydrogen (to form a 2-aminopurine), respectively.
摘要翻译: 本发明提供了通过用适当的侧链前体9取代2-氨基-6-氯嘌呤(ACP)合成喷昔洛韦和泛昔洛韦的方法,随后将6-氯部分转化为羟基部分(即, 形成鸟嘌呤)或氢(形成2-氨基嘌呤)。
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公开(公告)号:US06320051B1
公开(公告)日:2001-11-20
申请号:US09674102
申请日:2000-10-26
申请人: John Michael Berge , Pamela Brown , John Stephen Elder , Andrew Keith Forrest , Dieter Wolfgang Hamprecht , Richard Lewis Jarvest , David Jonathan McNair , Robert John Sheppard
发明人: John Michael Berge , Pamela Brown , John Stephen Elder , Andrew Keith Forrest , Dieter Wolfgang Hamprecht , Richard Lewis Jarvest , David Jonathan McNair , Robert John Sheppard
IPC分类号: A61K3147
CPC分类号: C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Compounds of formula (I) are inhibitors of the bacterial enzyme S aureus methionyl tRNA synthetase and are of use in treating bacterial infections.
摘要翻译: 式(I)化合物是细菌性金黄色葡萄球菌甲硫氨酰tRNA合成酶的抑制剂,可用于治疗细菌感染。
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公开(公告)号:US5886215A
公开(公告)日:1999-03-23
申请号:US884731
申请日:1997-06-30
IPC分类号: C07C31/22 , C07C43/178 , C07C69/007 , C07C69/63 , C07D319/06 , C07D473/00 , C07F9/6561 , C07C67/02
CPC分类号: C07D473/00 , C07C31/22 , C07C43/1782 , C07C69/007 , C07C69/63 , C07D319/06 , C07F9/65616
摘要: The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to form a guanine) or hydrogen (to form a 2-aminopurine), respectively; and 2-acetoxymethyl-4-halo-butyl-1-yl acetates.
摘要翻译: 本发明提供了通过用适当的侧链前体9取代2-氨基-6-氯嘌呤(ACP)合成喷昔洛韦和泛昔洛韦的方法,随后将6-氯部分转化为羟基部分(即, 形成鸟嘌呤)或氢(以形成2-氨基嘌呤); 和2-乙酰氧基甲基-4-卤代丁基-1-基乙酸酯。
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公开(公告)号:US07569550B2
公开(公告)日:2009-08-04
申请号:US10556645
申请日:2004-05-11
申请人: Sulejman Alihodzic , Andrew Keith Forrest , Richard Lewis Jarvest , Gorjana Lazarevski , Drazen Pavlovic
发明人: Sulejman Alihodzic , Andrew Keith Forrest , Richard Lewis Jarvest , Gorjana Lazarevski , Drazen Pavlovic
CPC分类号: C07H17/08
摘要: The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译: 本发明涉及在式(I)的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物,其制备方法及其在治疗或预防全身或局部微生物感染中的用途 人或动物体。
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公开(公告)号:US20080221158A1
公开(公告)日:2008-09-11
申请号:US10556709
申请日:2004-05-11
IPC分类号: A61K31/47 , C07D267/00 , A61P31/00
CPC分类号: C07H17/08
摘要: The present invention relates to 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译: 本发明涉及在式(I)的4“位取代的15元大环内酯及其药学上可接受的衍生物,其制备方法及其在治疗或预防人或动物体内全身或局部微生物感染中的用途 身体。
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公开(公告)号:US06573378B1
公开(公告)日:2003-06-03
申请号:US08357363
申请日:1994-12-15
IPC分类号: C07D47318
CPC分类号: C07D473/00 , C07C31/22 , C07C43/1782 , C07C69/007 , C07D319/06 , C07F9/65616
摘要: A compound of formula (I) or a salt or acyl derivative thereof, in which X represents chlorine, C1-6 alkoxy, phenoxy, phenyl C1-6 alkoxy, NH2, —OH or —SH, is useful in treating viral infections.
摘要翻译: 式(I)化合物或其盐或酰基衍生物,其中X表示氯,C1-6烷氧基,苯氧基,苯基C1-6烷氧基,NH2,-OH或-SH,可用于治疗病毒感染。
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公开(公告)号:US5684153A
公开(公告)日:1997-11-04
申请号:US258167
申请日:1994-06-10
IPC分类号: C07C31/22 , C07C43/178 , C07C69/007 , C07C69/63 , C07D319/06 , C07D473/00 , C07F9/6561 , C07D473/18 , C07D473/32
CPC分类号: C07D473/00 , C07C31/22 , C07C43/1782 , C07C69/007 , C07C69/63 , C07D319/06 , C07F9/65616
摘要: The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting the compound 2-amino-6-chloropurine (ACP) with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate, followed by displacement of the 6-chloro moiety with a hydroxy moiety (i.e. to form a guanine derivative) or with hydrogen (to form the 2-aminopurine derivative), respectively.
摘要翻译: 本发明提供通过用2-乙酰氧基甲基-4-(离去基) - 丁-1-基乙酸酯替代化合物2-氨基-6-氯嘌呤(ACP),然后通过以下方式合成喷昔洛韦和泛昔洛韦的方法: 分别用羟基部分(即形成鸟嘌呤衍生物)或用氢(以形成2-氨基嘌呤衍生物)置换6-氯部分。
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公开(公告)号:US07351696B2
公开(公告)日:2008-04-01
申请号:US10533461
申请日:2003-10-29
CPC分类号: C07H17/08
摘要: The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的衍生物,其制备方法及其在治疗或预防人或动物体内的全身或局部微生物感染中的用途。
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公开(公告)号:US07160907B2
公开(公告)日:2007-01-09
申请号:US11004751
申请日:2004-12-03
CPC分类号: C07D331/04 , C07C271/66 , C07C2601/10 , C07C2603/82 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/22 , C07D207/26 , C07D207/273 , C07D207/404 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/40 , C07D213/64 , C07D231/22 , C07D239/30 , C07D239/42 , C07D239/49 , C07D239/54 , C07D261/12 , C07D263/24 , C07D265/30 , C07D295/185 , C07D295/26 , C07D307/20 , C07D307/66 , C07D317/10 , C07D319/06 , C07D333/32 , C07D401/06 , C07D493/04
摘要: Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy.
摘要翻译: 具有下列公式的Pleuromutilin化合物:用于抗菌治疗。
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