公开(公告)号：US06283031B1

公开(公告)日：2001-09-04

申请号：US09192263

申请日：1998-11-16

申请人： Atsushi Kakuta ,  Masatoshi Sakata ,  Yasuo Takano ,  Shigenori Suematsu ,  Yutaka Shoji

发明人： Atsushi Kakuta ,  Masatoshi Sakata ,  Yasuo Takano ,  Shigenori Suematsu ,  Yutaka Shoji

IPC分类号： B41C110

CPC分类号： B41C1/1066

摘要： A solid-ink printing original plate which comprises a substrate and an image comprising ink dots formed on the substrate, and which is produced by a process comprising the steps of: melting a solid ink that is a solid at a room temperature; and jetting the melt of the solid ink onto a substrate to form ink dots, wherein the solid ink has a penetration index of not more than 5 at a room temperature. Also disclosed is a process for producing the solid-ink printing original plate.

摘要翻译： 一种固体油墨印刷原版，其包括基材和包含形成在基材上的墨点的图像，其通过包括以下步骤的方法制备：包括以下步骤：在室温下熔化固体油墨; 并将固体油墨的熔体喷射到基材上以形成油墨点，其中固体油墨在室温下的渗透指数不超过5。 还公开了一种生产固体油墨印刷原版的方法。

公开(公告)号：US5789425A

公开(公告)日：1998-08-04

申请号：US612829

申请日：1996-03-15

申请人： Yasuo Takano ,  Masanori Takadoi ,  Kei Okazaki ,  Takashi Hirayama ,  Atsuhiro Yamanishi

发明人： Yasuo Takano ,  Masanori Takadoi ,  Kei Okazaki ,  Takashi Hirayama ,  Atsuhiro Yamanishi

IPC分类号： A61K31/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/55 ,  A61P25/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D405/14

摘要： Imidazolidinone derivatives represented by a following general formula (1) or pharmacologically permissible acid addition salts with cholinergic activity (muscarine M.sub.1 activity) provide compounds useful for the therapy of senile dementia. ##STR1## (wherein R denotes a lower alkyl group which may be substituted by halogen, or the like, R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms or lower alkyl groups, R.sup.3 denotes a formula ##STR2## (wherein R.sup.4 denotes a lower alkyl group which may be substituted by halogen, or the like, q denotes 0 to 3, and R.sup.5 denotes a hydrogen atom or the like), m and n denote 0 to 3, p denotes 1 to 3, and X denotes an oxygen atom or sulfur atom).

摘要翻译： PCT No.PCT / JP94 / 01506 Sec。 371日期：1996年3月15日 102（e）1996年3月15日PCT 1994年9月12日PCT PCT。 公开号WO95 / 07906 日期：1995年3月23日由以下通式（1）表示的咪唑烷酮衍生物或具有胆碱能活性的药理学允许的酸加成盐（毒蕈碱M1活性）提供可用于治疗老年痴呆的化合物。 （1）（其中R表示可被卤素取代的低级烷基等，R 1和R 2表示相同或不同的氢原子或低级烷基，R 3表示下式：其中R 4表示 可以被卤素取代的低级烷基等，q表示0〜3，R5表示氢原子等），m表示0〜3，p表示1〜3，X表示 氧原子或硫原子）。

公开(公告)号：US20090036489A1

公开(公告)日：2009-02-05

申请号：US11886909

申请日：2006-03-22

申请人： Masahiro Nomura ,  Yasuo Takano ,  Kazuhiro Yumoto ,  Kyoko Okada ,  Takehiro Shinozaki ,  Shigeki Isogai

发明人： Masahiro Nomura ,  Yasuo Takano ,  Kazuhiro Yumoto ,  Kyoko Okada ,  Takehiro Shinozaki ,  Shigeki Isogai

IPC分类号： A61K31/4535 ,  C07D401/12 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D417/12 ,  C07D409/12

摘要： The present invention provides cyclic aminophenylalkanoic acid derivatives that act as agonists for human peroxisome proliferator-activated receptors (PPARs), in particular human PPARα isoform, and are effective in the treatment of abnormal lipid metabolism, diabetes and other disorders. The present invention also provides addition salts of such cyclic aminophenylalkanoic acid derivatives and pharmaceutical compositions containing these compounds.Specifically, the present invention provides cyclic aminophenylalkanoic acid derivatives represented by the following general formula (1): , or pharmaceutically acceptable salts thereof.

摘要翻译： 本发明提供了作为人类过氧化物酶体增殖物激活受体（PPAR），特别是人PPARα同种型的激动剂的环状氨基苯基链烷酸衍生物，并且有效治疗脂质代谢异常，糖尿病等疾病。 本发明还提供了这种环状氨基苯基链烷酸衍生物的加成盐和含有这些化合物的药物组合物。 具体地说，本发明提供由以下通式（1）表示的环状氨基苯基链烷酸衍生物或其药学上可接受的盐。

公开(公告)号：US20070249580A1

公开(公告)日：2007-10-25

申请号：US11659854

申请日：2005-08-11

申请人： Masahiro Nomura ,  Yasuo Takano ,  Kazuhiro Yumoto ,  Takehiro Shinozaki ,  Shigeki Isogai ,  Koji Murakami

发明人： Masahiro Nomura ,  Yasuo Takano ,  Kazuhiro Yumoto ,  Takehiro Shinozaki ,  Shigeki Isogai ,  Koji Murakami

IPC分类号： A61K31/426 ,  A61K31/445 ,  A61K31/5375 ,  A61K31/55 ,  A61P3/10 ,  C07D211/36 ,  C07D223/00 ,  C07D277/02 ,  C07D413/00

CPC分类号： C07D417/12 ,  C07D211/22 ,  C07D211/26 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60

摘要： The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及作为人类过氧化物酶体增殖物激活受体（PPAR）激动剂的脂质代谢异常的治疗有效的环状氨基苯甲酸衍生物，特别是作为对人PPARα同种型的激动剂的添加 其盐，以及含有这些化合物的药物组合物。 由通式（1）表示的环状氨基苯甲酸衍生物[其中环Ar表示可具有取代基的芳基等; Y表示C 1 -C 4亚烷基，C 2 -C 4亚烯基，C 2 C 3 -C 4亚炔基等; Z表示氧原子，硫原子或 - （CH 2 CH 2）n - （n表示0,1或2）。 X表示氢原子，卤素原子，可被卤素原子取代的低级烷基等; R代表氢原子或低级烷基，-COOR代替环W的结合位置的邻位或甲基位置]或其药学上可接受的盐。

公开(公告)号：US20070231684A1

公开(公告)日：2007-10-04

申请号：US11729904

申请日：2007-03-30

申请人： Yasuo Takano ,  Keiji Saisho ,  Hidekazu Yamamoto

发明人： Yasuo Takano ,  Keiji Saisho ,  Hidekazu Yamamoto

IPC分类号： H01M2/26 ,  H01M4/58 ,  H01M4/62 ,  H01M2/02

CPC分类号： H01M4/621 ,  H01M2/0285 ,  H01M2/266 ,  H01M4/0471 ,  H01M4/1395 ,  H01M4/386 ,  H01M4/622 ,  H01M10/052 ,  H01M2004/021

摘要： A lithium secondary battery includes: a plurality of sheets of a positive electrode; at least one sheet of a negative electrode; a separator disposed between each of the positive electrode sheets and the negative electrode sheet; an electrode assembly (20) including the positive electrode, the negative electrode, and the separators; a battery case for accommodating the electrode assembly; and positive electrode current collector tabs (1), attached to individual sheets of the positive electrode, for connecting the sheets of the positive electrode to a positive electrode terminal portion of the battery case. The electrode assembly (20) is formed so that the plurality of sheets of positive electrode and the at least one sheet of the negative electrode are stacked with the separators interposed therebetween. In the electrode assembly in which the electrodes are stacked, the positive electrode current collector tabs are disposed staggered at a plurality of locations.

摘要翻译： 锂二次电池包括：多片正极片; 至少一片负极; 设置在每个正极片和负极片之间的隔板; 包括正极，负极和隔板的电极组件（20）; 用于容纳电极组件的电池壳体; 和正极集电体接头（1），其连接到正极的各个片上，用于将正极片连接​​到电池壳体的正极端子部分。 电极组件（20）形成为使得多个正极板和至少一个负极片层叠在一起，隔板之间被层叠。 在其中堆叠电极的电极组件中，正极集电片在多个位置交错配置。

公开(公告)号：US06632813B1

公开(公告)日：2003-10-14

申请号：US09926057

申请日：2001-08-22

申请人： Yasuo Takano ,  Futoshi Shiga ,  Tsuyoshi Anraku ,  Kazunori Fukuchi

发明人： Yasuo Takano ,  Futoshi Shiga ,  Tsuyoshi Anraku ,  Kazunori Fukuchi

IPC分类号： C07D24702

CPC分类号： A61K31/498

摘要： The invention provides compounds with antagonism against excitatory amino acid receptors, in particular, AMPA receptor having 6-substituted-7-heteroquinoxalinecarboxylic acid derivatives and addition salts thereof as effective ingredients, and processes for the preparation of both. The compounds are 6-substituted-7-heteroquinoxalinecarboxylic acid derivatives represented by the formula (1) where A denotes a single bond or methylene (CH2), Y denotes a nitrogen atom or ═CH—, V denotes a single bond or methylene (CH2), T denotes a hydroxyl group, amino group, lower alkoxycarbonyl group, carboxyl group, aldehyde group or the like, Q denotes a halogen atom, lower alkyl group or lower alkoxy group, and R1 denotes a hydroxyl group, lower alkoxy group or the like, and addition salts thereof.

摘要翻译： 本发明提供具有对兴奋性氨基酸受体的拮抗作用的化合物，特别是具有6-取代-7-异喹喔啉羧酸衍生物的AMPA受体及其加成盐作为有效成分，以及二者的制备方法。 化合物是由式（1）表示的6-取代-7-异喹喔啉羧酸衍生物，其中A表示单键或亚甲基（CH 2 PDAT>），Y表示氮原子 或= CH-，V表示单键或亚甲基（CH 2 PDAT>），T表示羟基，氨基，低级烷氧基羰基，羧基，醛基或 Q表示卤素原子，低级烷基或低级烷氧基，R 1表示羟基，低级烷氧基等，及其加成盐。

公开(公告)号：US06264310B1

公开(公告)日：2001-07-24

申请号：US09031597

申请日：1998-02-27

申请人： Takuji Toru ,  Nobuhiro Noto ,  Kenichi Kugai ,  Takao Matsuoka ,  Yoshitaka Akiyama ,  Kazuaki Akimoto ,  Nobuhiro Kurosawa ,  Yasuo Takano

发明人： Takuji Toru ,  Nobuhiro Noto ,  Kenichi Kugai ,  Takao Matsuoka ,  Yoshitaka Akiyama ,  Kazuaki Akimoto ,  Nobuhiro Kurosawa ,  Yasuo Takano

IPC分类号： B41J2045

CPC分类号： B41J2/1623 ,  B41J2/14274 ,  B41J2/1612 ,  B41J2002/14491 ,  B41J2202/18

摘要： An on-demand ink jet head includes a plurality of piezoelectric elements in alignment with one another with one end of each facing in the same direction. The end of each piezoelectric element is bonded by an adhesive material to a diaphragm which, together with a nozzle plate, forms a pressurizing chamber. To confine the fluid state adhesive material expelled out of the endmost piezoelectric elements, a dummy piezoelectric element is disposed outside each endmost piezoelectric element. The adhesive material, when dried, serves as a damper of the piezoelectric element for damping unwanted vibrations of the piezoelectric elements. By the provision of the dummy piezoelectric elements, the distribution of the adhesive material becomes substantially even between the piezoelectric elements, resulting in uniform operations of the piezoelectric elements.

摘要翻译： 按需喷墨头包括彼此对准的多个压电元件，每个压电元件的一端各自朝向相同的方向。 每个压电元件的端部通过粘合剂材料粘合到隔膜上，隔膜与喷嘴板一起形成加压室。 为了限制排出最差压电元件的流体状态的粘合剂材料，在每个最末端的压电元件的外侧设置有虚拟的压电元件。 干燥时的粘合剂材料用作压电元件的阻尼器，用于阻尼压电元件的不期望的振动。 通过设置虚拟压电元件，粘合材料的分布在压电元件之间变得基本均匀，导致压电元件的均匀操作。

公开(公告)号：US5300515A

公开(公告)日：1994-04-05

申请号：US824983

申请日：1992-01-24

申请人： Yasuo Takano ,  Masanori Takadoi ,  Takashi Hirayama ,  Atsuhiro Yamanishi

发明人： Yasuo Takano ,  Masanori Takadoi ,  Takashi Hirayama ,  Atsuhiro Yamanishi

IPC分类号： C07D211/60 ,  C07D401/04 ,  C07D401/14 ,  C07D417/04 ,  C07D211/68

CPC分类号： C07D401/04 ,  C07D211/60 ,  C07D401/14 ,  C07D417/04

摘要： Anti-dementia medicaments comprising a carbamic acid derivative or their pharmaceutically acceptable acid addition salts having an anti-amnesic activity as an active ingredient are provided. The carbamic acid derivatives are represented by a general formula (1) ##STR1## wherein Ar denotes an aromatic heterocyclic ring which may have at least one substituent or its benzene-condensed ring, or phenyl group which may have at least one substituent, R.sup.1 denotes hydrogen atom or lower alkyl group, R.sup.2 denotes lower alkyl group which may be substituted with halogen atom, phenyl group which may have at least one substituent, naphthyl group, or five- or six-membered heterocyclic ring and its benzene-condensed ring, X and Y, which may be the same or different, denote sulfur atom or oxygen atom.

摘要翻译： 提供了包含氨基甲酸衍生物或其药学上可接受的具有抗遗忘活性的酸加成盐作为有效成分的抗痴呆药物。 氨基甲酸衍生物由通式（1）（*化学结构*）（1）表示，其中Ar表示可具有至少一个取代基的芳族杂环或其苯稠合的环，或可以具有 至少一个取代基，R1表示氢原子或低级烷基，R2表示可被卤素原子取代的低级烷基，可具有至少一个取代基的苯基，萘基或五元或六元杂环， 苯稠合环，X和Y可以相同或不同，表示硫原子或氧原子。

公开(公告)号：US5137909A

公开(公告)日：1992-08-11

申请号：US523577

申请日：1990-05-14

申请人： Hidehiko Miura ,  Naoki Harano ,  Yasuo Takano ,  Toshiro Mochizuki ,  Yoshinori Takahashi, deceased ,  Takashi Nagayama

发明人： Hidehiko Miura ,  Naoki Harano ,  Yasuo Takano ,  Toshiro Mochizuki ,  Yoshinori Takahashi, deceased ,  Takashi Nagayama

IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/535 ,  A61P3/06 ,  A61P9/10 ,  C07D209/30 ,  C07D209/58 ,  C07D209/90 ,  C07D401/12 ,  C07D471/04 ,  C07D471/06 ,  C07D491/04 ,  C07D491/056 ,  C07D498/06 ,  C07D505/00

CPC分类号： C07D401/12 ,  C07D209/30 ,  C07D209/90 ,  C07D471/04 ,  C07D491/04 ,  C07D505/00

摘要： An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R.sup.1, R.sup.2, R.sup.3, and R.sup.4 may be the same with or different from each other and are hydrogen, halogen, lower alkyl having 1 to 6 carbons, lower alkoxy having 1 to 6 carbons, acyl, substituted or unsubstituted amino, nitro, hydroxy, acyloxy, substituted or unsubstituted aralkyl, substituted or unsubstituted aryloxy, or substituted or unsubstituted aralkyloxy, or a combination of R.sup.2 and R.sup.3 may be methylenedioxy;R.sup.5 is hydrogen, lower alkyl having 1 to 6 carbons, or substituted or unsubstituted aralkyl; R and R.sup.4, or R.sup.1 and R.sup.5 may form together a six-membered ring constituted of methylene chains which may contain a heteroatom;R.sup.6 and R.sup.7 may be the same with or different from each other and are hydrogen, lower alkyl having 1 to 6 carbons, or substituted or unsubstituted aryl or a five- or six-membered heterocyclic ring;A is --COOR.sup.8 (wherein R.sup.8 is hydrogen, lower alkyl having 1 to 6 carbons, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl), or --CH.sub.2 OR.sup.9 (wherein R.sup.9 is hydrogen, lower alkyl having 1 to 6 carbons, lower alkenyl having 2 to 6 carbons, acyl or substituted or substituted aralkyl);and the method of producing the same, which comprises reacting, in the presence of a base, useful for hyperlipidemia and arteriosclerosis, is disclosed.

公开(公告)号：US5119146A

公开(公告)日：1992-06-02

申请号：US609541

申请日：1990-11-06

申请人： Shogo Nobumori ,  Kazuo Sakaki ,  Yasuo Takano ,  Tatsuo Matsuda

发明人： Shogo Nobumori ,  Kazuo Sakaki ,  Yasuo Takano ,  Tatsuo Matsuda

IPC分类号： B41J13/00 ,  B65H43/00 ,  G03G15/00

CPC分类号： G03G15/6529 ,  G03G2215/00945

摘要： A paper conveying apparatus which facilitates increased printing speed in a printer, such as a laser printer, by providing rollers which are rotated at different respective speeds at different times during a paper feeding and image transfer operation, so as to provide even feeding of the paper to an image transfer device. The paper is fed, one sheet at a time, relatively rapidly to the image transfer device, and at a slower speed, in synchronism with the image transfer operation, while transfer is being effected.

摘要翻译： 一种纸张输送装置，其通过提供在进纸和图像转印操作期间的不同时间以不同的相应速度旋转的辊来促进诸如激光打印机的打印机中的打印速度的提高，从而提供纸张的均匀进给 到图像传送装置。 在转印的同时，纸张被一次一张地进给到图像转印装置，并且以较慢的速度与图像转印操作同步地进给。