Heterocyclic kinase inhibitors
    27.
    发明授权
    Heterocyclic kinase inhibitors 失效
    杂环激酶抑制剂

    公开(公告)号:US08759338B2

    公开(公告)日:2014-06-24

    申请号:US13061009

    申请日:2009-08-31

    CPC分类号: C07D401/12

    摘要: New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

    摘要翻译: 提供了新的化合物,组合物和方法抑制Provirus与人或动物受试者中与肿瘤发生相关的Maloney激酶(PIM激酶)活性的整合。 在某些实施方案中,化合物和组合物有效抑制至少一种PIM激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用,用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症,例如癌症。