公开(公告)号：US20060148812A1

公开(公告)日：2006-07-06

申请号：US11254276

申请日：2005-10-20

申请人： Carl Illig ,  Shelley Ballentine ,  Jinsheng Chen ,  Sanath Meegalla ,  M. Rudolf ,  Mark Wall ,  Ken Wilson ,  Renee Desjarlais ,  Carl Manthey ,  Christopher Flores ,  Chris Molloy

发明人： Carl Illig ,  Shelley Ballentine ,  Jinsheng Chen ,  Sanath Meegalla ,  M. Rudolf ,  Mark Wall ,  Ken Wilson ,  Renee Desjarlais ,  Carl Manthey ,  Christopher Flores ,  Chris Molloy

IPC分类号： A61K31/496 ,  A61K31/4545 ,  C07D409/14 ,  A61K31/4178

CPC分类号： C07D307/71 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14

摘要： The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

摘要翻译： 本发明涉及式I化合物：其中A，X，R 2和W在本说明书中列出，以及其抑制蛋白质的溶剂合物，水合物，互变异构体和药学上可接受的盐 酪氨酸激酶，特别是c-fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，结肠癌，胃癌，毛细胞白血病和非小细胞肺癌的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 还提供了骨质疏松症，佩吉特氏病和其它骨吸收介导包括关节炎，假体失败，溶骨性骨肉瘤，骨髓瘤以及与式I化合物对骨的肿瘤转移的其它疾病。

公开(公告)号：US20050264034A1

公开(公告)日：2005-12-01

申请号：US10946554

申请日：2004-09-21

申请人： Christopher Flores

发明人： Christopher Flores

IPC分类号： B60J1/00 ,  B60R99/00 ,  B62D33/027 ,  B62D35/00

CPC分类号： B62D33/0273 ,  B62D35/007

摘要： An inflatable air spoiler for the use with a vehicle to reduce wind resistance. The inflatable air spoiler is made from abrasion resistant materials capable of forming a wedge shaped air spoiler. Securement of the inflatable air spoiler to a vehicle can be achieved with hooks, snaps and other conventional means. In another embodiment, securement of the inflatable spoiler in a vehicle's cargo bed is achieved by pressurizing the inflatable spoiler so its side panels or portions of its exterior surfaces are urged against the side walls of the cargo bed. Further securement is achieved by ballast chambers located on the bottom region of the inflatable air spoiler.

摘要翻译： 用于与车辆一起使用的可充气式空气扰流器以降低风阻。 充气式空气扰流器由能够形成楔形空气扰流器的耐磨材料制成。 通过钩，卡扣和其他常规手段可以实现充气式空气扰流器到车辆的安全。 在另一个实施例中，通过对充气扰流器进行加压来实现将充气扰流板固定在车辆的货物床中，使得其侧板或其外表面的一部分被推靠在货物床的侧壁上。 通过位于可充气式空气扰流器的底部区域上的压载舱来实现进一步的固定。

公开(公告)号：US06693890B1

公开(公告)日：2004-02-17

申请号：US09594468

申请日：2000-06-14

申请人： Karl Yick ,  Oswald Correya ,  Ronald Ross ,  Christopher Flores

发明人： Karl Yick ,  Oswald Correya ,  Ronald Ross ,  Christopher Flores

IPC分类号： H04B7216

CPC分类号： H04B1/70752 ,  H04B1/70775

摘要： An acquisition module for acquiring signal timing in a CDMA system has a register for storing and organizing synchronization code, at least 4 match filters for match filtering between I/Q samples and the corresponding synchronization code, at least 4 absolute value blocks for determining absolute values of match filtering results, a summation function for summing results obtained through match filtering and through absolute value taking, and a control logic for controlling the acquisition process, characterized in that the acquisition module loads a 64-bit section of synchronization code and I/Q complex samples and match filters them in a simultaneous manner and, upon registering a value greater than a preset threshold, acquires an initial timing, the initial timing being verified over the remaining 64-bit sections of synchronization code using the same control circuitry used in acquiring the timing.

摘要翻译： 用于在CDMA系统中获取信号定时的获取模块具有用于存储和组织同步码的寄存器，用于在I / Q采样和对应的同步码之间进行匹配滤波的至少4个匹配滤波器，用于确定绝对值的至少4个绝对值块 匹配滤波结果，用于通过匹配滤波和通过绝对值获取获得的结果求和的求和函数，以及用于控制获取过程的控制逻辑，其特征在于，采集模块加载64位部分的同步码和I / Q 复杂样本和匹配以同时方式对它们进行滤波，并且在注册大于预设阈值的值时，获取初始定时，使用在采集中使用的相同控制电路在剩余的64位部分的同步码中验证初始定时 时机。

公开(公告)号：US5267244A

公开(公告)日：1993-11-30

申请号：US789348

申请日：1991-11-08

申请人： David G. Messerschmitt ,  Christopher Flores ,  Hulhung Lu

发明人： David G. Messerschmitt ,  Christopher Flores ,  Hulhung Lu

IPC分类号： H03M5/14 ,  H03M13/31 ,  H04L25/49 ,  H04M1/725 ,  H04B7/212

CPC分类号： H04M1/72502 ,  H03M13/31 ,  H03M5/145 ,  H04L25/4908

摘要： In a wireless communication system between a base unit and a remote unit, the base unit transmits periodically a sync signal in a first selected time period in a selected frequency channel. The remote unit scans the frequency channels to detect the sync signal. The remote unit transmits a response signal in the selected frequency channel. The response signal is transmitted in a second selected time period different from the first selected time period. In addition, the remote unit transmits a first control signal encoded by a first code in the selected frequency channel in a third selected time period, different from the first and second selected time periods, containing a set of functional capabilities of the remote unit. The base unit receives and decodes the first control signal to derive the set of functional capabilities of the remote unit and compares it to its own set of functional capabilities to determine a common set of functional capabilities. The base unit transmits a second control signal encoded by the first code in the same selected frequency channel in a fourth selected time period containing the common set of functional capabilities. Thereafter, communication between the base unit and the remote unit is based upon a functional capability selected from the common set.

摘要翻译： 在基本单元和远程单元之间的无线通信系统中，基站单元在所选择的频率信道中的第一选定时间周期内周期性地发送同步信号。 远程单元扫描频道以检测同步信号。 远程单元在所选择的频道中发送响应信号。 响应信号在与第一选择的时间段不同的第二选定时间段内发送。 此外，远程单元在与包含远程单元的一组功能能力的第一和第二选定时间段不同的第三选定时间段内发送由所选频道中的第一代码编码的第一控制信号。 基本单元接收并解码第一控制信号以导出远程单元的一组功能能力，并将其与其自己的一组功能能力进行比较，以确定一组共同的功能能力。 基站单元在包含公共功能能力集合的第四选定时间段内发送由相同选定频道中的第一代码编码的第二控制信号。 此后，基本单元和远程单元之间的通信基于从公共集合中选择的功能能力。

公开(公告)号：US4698804A

公开(公告)日：1987-10-06

申请号：US693512

申请日：1985-01-22

申请人： Christopher Flores ,  Bhaskarpillai Gopinath

发明人： Christopher Flores ,  Bhaskarpillai Gopinath

IPC分类号： H04L12/433 ,  H04J3/08 ,  H04J3/24

CPC分类号： H04L12/433

摘要： A digital transmission system includes a plurality of stations sharing a common transmission line. Variable length messages, set off by flags, are exchanged between pairs of stations. While a message is being received, the downstream portion of the transmission line is segmented to permit simultaneous use by another station pair. If a message is received from an upstream station while a message is being transmitted downstream, an abort message flag terminates the transmitted message abruptly to permit flowthrough of the received message. When any station is not in use or out of order, it is bypassed to permit use of the transmission line by the rest of the stations.

摘要翻译： 数字传输系统包括共享公共传输线的多个站。 由标志引起的可变长度消息在站对之间交换。 当接收到消息时，传输线的下游部分被分段以允许另一个站对同时使用。 如果在下游发送消息时从上游站接收到消息，则中止消息标志突然终止发送的消息，以允许所接收消息的穿越。 当任何电台不使用或不按顺序时，它被旁路以允许其余电台使用传输线。

公开(公告)号：US4532626A

公开(公告)日：1985-07-30

申请号：US399428

申请日：1982-07-19

申请人： Christopher Flores ,  Bhaskarpillai Gopinath ,  John O. Limb

发明人： Christopher Flores ,  Bhaskarpillai Gopinath ,  John O. Limb

IPC分类号： H04L12/417 ,  H04J3/02 ,  H04J3/00 ,  H04J6/00

CPC分类号： H04L12/417

摘要： In order to control the transfer of packets of information among a plurality of stations, e.g., digital computers, the instant communications system, station and protocol contemplate first and second oppositely directed signal paths. At least two stations are coupled to both the first and the second signal paths. A station includes arrangements for reading one signal from the first path and for writing another signal on the first path. The one signal is read from the first path by an arrangement which electrically precedes the arrangement for writing the other signal on the first path. A similar read arrangement is electrically preceding a write arrangement on the second path. If the station has a packet to transmit, it can overwrite a busy control field of the one signal packet on either path. Having read the one signal on the path, a logical interpretation may be made within the station as to whether the path is busy or is not busy. If the path is not busy, the packet may be written on the path by overwriting any signal thereon. If the path is busy, the station may defer the writing until the path is detected as not busy through a busy control field. The packets flow down the path to a destination station. Eventually all packets will be transmitted and the busy control field may be detected at an end station for indicating the event that all packets have been transmitted. The end station on one path acts as the head station on the other oppositely directed path. Hence, responsive to detecting that all packets have been transmitted, the head station on the other path may transmit an end cycle packet, responsive to which event a new cycle may be started by initializing each station on the one path and by permitting each initialized station to transmit.

摘要翻译： 为了控制多个站（例如数字计算机）之间的信息包的传送，即时通信系统，站和协议考虑第一和第二相反方向的信号路径。 至少两个站耦合到第一和第二信号路径两者。 站包括用于从第一路径读取一个信号并在第一路径上写入另一个信号的布置。 通过在第一路径上写入另一信号的布置之前的布置从第一路径读取一个信号。 类似的读取布置在第二路径上的写入布置之前。 如果站具有要发送的数据包，则可以覆盖任一路径上的一个信号包的繁忙控制字段。 在路径上读取了一个信号后，可以在站内进行关于路径是忙还是不忙的逻辑解释。 如果路径不忙，则可以通过在其上覆盖任何信号将路径写入路径。 如果路径正忙，则站可能推迟写入，直到通过忙控制字段检测到路径不忙。 数据包流向目的站的路径。 最终将发送所有分组，并且可以在终端站检测忙控制字段，以指示所有分组已经被发送的事件。 一个路径上的终端站作为另一个相对定向路径上的头站。 因此，响应于检测到所有分组已经被发送，另一路径上的头站可以发送结束周期分组，响应于哪个事件可以通过在一个路径上初始化每个站并且通过允许每个初始化的站来启动新的周期 发送。

公开(公告)号：US20080020376A1

公开(公告)日：2008-01-24

申请号：US10591892

申请日：2005-03-09

申请人： Armen Akopian ,  Christopher Flores

发明人： Armen Akopian ,  Christopher Flores

IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N33/53 ,  G01N33/566

CPC分类号： C12N15/1096 ,  C12N15/1086

摘要： Disclosed are cDNA expression libraries enriched for cDNAs that encode, for example, secretory and membrane-bound proteins and to methods for making such libraries. Also disclosed are methods for using the cDNA expression libraries disclosed herein to screen for proteins, nucleic acids, and agents that modulate the function and/or expression of proteins.

摘要翻译： 公开了富集编码例如分泌和膜结合蛋白的cDNA的cDNA表达文库以及制备这种文库的方法。 还公开了使用本文公开的cDNA表达文库筛选调节蛋白质的功能和/或表达的蛋白质，核酸和试剂的方法。

公开(公告)号：US5745480A

公开(公告)日：1998-04-28

申请号：US681191

申请日：1996-07-22

申请人： Saman Behtash ,  Christopher Flores ,  Adel Ghanem

发明人： Saman Behtash ,  Christopher Flores ,  Adel Ghanem

IPC分类号： H04B7/005 ,  H04J13/00 ,  H04W28/18 ,  H04W52/26 ,  H04J13/02 ,  H04Q7/34

CPC分类号： H04W52/265 ,  H04J13/00 ,  H04W28/18 ,  H04W52/267

摘要： A multi-rate wireless communications system that supports a plurality of distributed user terminals in full-duplex simultaneous communications with a central base station, where each user terminal is provided on demand with one of multiple bit rates at a negotiated QOS is provided. Each user is assigned a variable bit rate, a variable processing gain, a variable transmit power and a unique fixed rate spreading code, resulting in a constant bandwidth signal received at a relative power level corresponding to the negotiated QOS. This application can be applied to systems including wireless local loop and mobile cellular. By adjusting signal energy and interference energy, variable bit rates and negotiated QOS parameters can be supported. The forward link between base-station and user terminal, and the reverse link between the user terminal and base-station, can correspond to either a Frequency Division Duplexing (FDD) arrangement where the forward and reverse links occupy different carrier frequencies but overlap in time, or a Time Division Duplexing (TDD) arrangement where the forward and reverse links occupy the same carrier frequency but are in non-overlapping time intervals.

摘要翻译： 提供了一种多速率无线通信系统，其支持与中央基站进行全双工同步通信的多个分布式用户终端，其中每个用户终端按照协商提供的QOS中的多个比特率之一按需提供。 为每个用户分配了可变比特率，可变处理增益，可变发射功率和唯一固定速率扩展码，导致在对应于协商的QOS的相对功率电平下接收的恒定带宽信号。 该应用可以应用于无线本地环路和移动蜂窝系统。 通过调整信号能量和干扰能量，可以支持可变比特率和协商的QOS参数。 基站和用户终端之间的前向链路以及用户终端与基站之间的反向链路可以对应于频分双工（FDD）布置，其中正向和反向链路占用不同的载波频率，但是在时间上重叠 ，或时分双工（TDD）布置，其中正向链路和反向链路占据相同的载波频率但处于非重叠的时间间隔。

公开(公告)号：US5553076A

公开(公告)日：1996-09-03

申请号：US236588

申请日：1994-05-02

申请人： Saman Behtash ,  Christopher Flores ,  Adel Ghanem

发明人： Saman Behtash ,  Christopher Flores ,  Adel Ghanem

IPC分类号： H04L12/28 ,  H04J3/16

CPC分类号： H04W28/26 ,  H04W4/12 ,  H04W48/08 ,  H04W56/0015 ,  H04W72/0446 ,  H04W84/12 ,  Y02B60/50

摘要： A protocol for wireless local area network communication between a base stationary unit and a plurality of wireless terminals is disclosed. The main features of this protocol is based upon channel reservation requests by active wireless terminals. Contention is resolved and authorization is granted with data message signals transmitted by the authorized wireless terminal either immediately for asynchronous service or periodically for a time-based service. The system further provides for the base stationary unit to query the receipt of the data message signal by the wireless terminal authorized to receive the transmission. If no response signal is received, then the base stationary unit would authorize for itself transmission of the data message to relay it, either "over the air" or via wired connection to another base stationary unit in another data cell. The synchronous nature of the method provides for power saving by allowing the receiver and/or transmitter to be powered down during idle and other time slots.

摘要翻译： 公开了一种用于基站固定单元与多个无线终端之间的无线局域网通信的协议。 该协议的主要特征是基于主动无线终端的信道预留请求。 竞争得到解决，授权由授权无线终端发送的数据消息信号立即进行异步服务或周期性地进行基于时间的服务。 该系统进一步提供基站固定单元，通过被授权接收传输的无线终端查询数据消息信号的接收。 如果没有接收到响应信号，则基站固定单元将授权本身传输数据消息以“通过空中”或通过有线连接将其中继到另一个数据信元中的另一个基站固定单元。 该方法的同步性质通过允许接收机和/或发射机在空闲和其他时隙期间断电来提供功率节省。

公开(公告)号：US5398258A

公开(公告)日：1995-03-14

申请号：US143170

申请日：1993-10-26

申请人： Chun-Meng Su ,  Saman Behtash ,  Keith Jarett ,  Huihung Lu ,  Christopher Flores ,  David G. Messerschmitt ,  Edward Chien

发明人： Chun-Meng Su ,  Saman Behtash ,  Keith Jarett ,  Huihung Lu ,  Christopher Flores ,  David G. Messerschmitt ,  Edward Chien

IPC分类号： H03M5/14 ,  H03M13/31 ,  H04J1/12 ,  H04J3/06 ,  H04J13/16 ,  H04L25/49 ,  H04M1/725 ,  H04L27/30

CPC分类号： H04J1/12 ,  H03M13/31 ,  H03M5/145 ,  H04J3/0605 ,  H04L25/4908 ,  H04M1/72502 ,  H04J13/16

摘要： In the present invention a wireless communication system is disclosed. A base unit communicates with a remote unit. The system comprises means for transmitting, using CDMA, between the base unit and the remote unit, in one of a plurality of frequencies channels selected. In one period of time, the base unit transmits and in another period of time, different from the one period, the remote unit transmits. Further, the system comprises means for changing the one frequency channel selected to another frequency channel, different from the one frequency channel, in response to interference in the one frequency channel. Thus, communication between the base unit and the remote unit is then affected over the another frequency channel.

摘要翻译： 在本发明中，公开了一种无线通信系统。 基本单元与远程单元通信。 该系统包括用于在所选择的多个频率信道之一中使用CDMA在基本单元和远程单元之间进行发送的装置。 在一个时间段内，基站单元在远程单元发送的另一个时间段内发送不同于一个周期的时间段。 此外，该系统包括用于响应于一个频率信道中的干扰而将选择的一个频率信道改变为与一个频率信道不同的另一频率信道的装置。 因此，基本单元和远程单元之间的通信然后在另一频率信道上受到影响。