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    Enriched Cdna Expression Libraries and Methods of Making and Using Same
    1.
    发明申请
    Enriched Cdna Expression Libraries and Methods of Making and Using Same 审中-公开
    丰富的Cdna表达文库及其制作和使用方法

    公开(公告)号：US20080020376A1

    公开(公告)日：2008-01-24

    申请号：US10591892

    申请日：2005-03-09

    申请人： Armen Akopian ,  Christopher Flores

    发明人： Armen Akopian ,  Christopher Flores

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N33/53 ,  G01N33/566

    CPC分类号： C12N15/1096 ,  C12N15/1086

    摘要： Disclosed are cDNA expression libraries enriched for cDNAs that encode, for example, secretory and membrane-bound proteins and to methods for making such libraries. Also disclosed are methods for using the cDNA expression libraries disclosed herein to screen for proteins, nucleic acids, and agents that modulate the function and/or expression of proteins.

    摘要翻译： 公开了富集编码例如分泌和膜结合蛋白的cDNA的cDNA表达文库以及制备这种文库的方法。 还公开了使用本文公开的cDNA表达文库筛选调节蛋白质的功能和/或表达的蛋白质，核酸和试剂的方法。

    Method for treating pain with prolactin antagonists
    2.
    发明授权
    Method for treating pain with prolactin antagonists 有权
    用催乳素拮抗剂治疗疼痛的方法

    公开(公告)号：US07507716B2

    公开(公告)日：2009-03-24

    申请号：US11482096

    申请日：2006-07-06

    申请人： Anibal Diogenes ,  Kenneth Hargreaves ,  Armen Akopian

    发明人： Anibal Diogenes ,  Kenneth Hargreaves ,  Armen Akopian

    IPC分类号： A61K38/16 ,  A61K38/00 ,  C07K14/435 ,  C07K14/00

    CPC分类号： A61K38/17

    摘要： The embodiments disclosed herein provide methods for inhibiting, reducing and/or treating pain in a subject by administering to a subject in need thereof a pharmaceutical formulation that includes a pharmacologically active compound that is adapted to disrupt PRL signaling in pain neurons. In certain embodiments, the compound is a PRL-R antagonist. In certain embodiments, the compound is adapted to alter the expression of one or more components involved in PRL signaling. Also provided for herein are methods to diagnose a pain disorder in a subject, comprising obtaining a measure of the amount of PRL or PRL mRNA in a biological sample.

    摘要翻译： 本文公开的实施方案提供了通过向有需要的受试者施用药物制剂来抑制，减少和/或治疗受试者的疼痛的方法，药物制剂包括适于破坏疼痛神经元中的PRL信号传导的药理活性化合物。 在某些实施方案中，化合物是PRL-R拮抗剂。 在某些实施方案中，化合物适于改变参与PRL信号传导的一种或多种组分的表达。 本文还提供了诊断受试者疼痛障碍的方法，包括获得生物样品中PRL或PRL mRNA量的量度。

    Prolactin and chronic and acute pain disorders
    3.
    发明申请
    Prolactin and chronic and acute pain disorders 有权
    催乳素和慢性和急性疼痛障碍

    公开(公告)号：US20070087966A1

    公开(公告)日：2007-04-19

    申请号：US11482096

    申请日：2006-07-06

    申请人： Anibal Diogenes ,  Kenneth Hargreaves ,  Armen Akopian

    发明人： Anibal Diogenes ,  Kenneth Hargreaves ,  Armen Akopian

    IPC分类号： A61K38/00 ,  A61K38/22

    CPC分类号： A61K38/17

    摘要： The embodiments disclosed herein provide methods for inhibiting, reducing and/or treating pain in a subject by administering to a subject in need thereof a pharmaceutical formulation that includes a pharmacologically active compound that is adapted to disrupt PRL signaling in pain neurons. In certain embodiments, the compound is a PRL-R antagonist. In certain embodiments, the compound is adapted to alter the expression of one or more components involved in PRL signaling. Also provided for herein are methods to diagnose a pain disorder in a subject, comprising obtaining a measure of the amount of PRL or PRL mRNA in a biological sample.

    摘要翻译： 本文公开的实施方案提供了通过向有需要的受试者施用药物制剂来抑制，减少和/或治疗受试者的疼痛的方法，药物制剂包括适于破坏疼痛神经元中的PRL信号传导的药理活性化合物。 在某些实施方案中，化合物是PRL-R拮抗剂。 在某些实施方案中，化合物适于改变参与PRL信号传导的一种或多种组分的表达。 本文还提供了诊断受试者疼痛障碍的方法，包括获得生物样品中PRL或PRL mRNA量的量度。