公开(公告)号：US20160361545A1

公开(公告)日：2016-12-15

申请号：US15043954

申请日：2016-02-15

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/05

CPC分类号： A61N1/36135 ,  A61B5/11 ,  A61B5/225 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36057 ,  A61N1/36132 ,  A61N1/36142 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/37288

摘要： A pulse generator is programmed to generate electrical stimulation to target a sacral nerve or a pudendal nerve of the patient. The electrical stimulation being delivered at least in part via a lead. The electrical stimulation is applied by ramping up a stimulation parameter over time. A first, a second, and a third physiological response are detected from the patient as a result of the electrical stimulation. A first value, a second value, and a third value of the stimulation parameter associated with the first, second, and third physiological response are measured, respectively. A placement of the lead inside the patient is evaluated based on at least one of: a chronological sequence in which the first, second, and third physiological responses occurred, a comparison of the first value with a predetermined threshold, or respective deviations of the second value or the third value from the first value.

摘要翻译： 编程脉冲发生器以产生电刺激以靶向患者的骶神经或阴部神经。 电刺激至少部分地经由引线输送。 通过随时间推移刺激参数来施加电刺激。 作为电刺激的结果，从患者检测第一，第二和第三生理反应。 分别测量与第一，第二和第三生理响应相关联的刺激参数的第一值，第二值和第三值。 基于以下至少一个来评估引线在患者体内的放置：发生第一，第二和第三生理反应的时间顺序，第一值与预定阈值的比较，或第二 值或第一个值的第三个值。

公开(公告)号：US20160303387A1

公开(公告)日：2016-10-20

申请号：US15191606

申请日：2016-06-24

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/36132 ,  A61N1/36142 ,  A61N1/37211 ,  A61N1/37252

摘要： One or more virtual objects are displayed on an electronic programmer. The virtual objects represent initiating and terminating a delivery of a medical therapy to a patient. An actuation of the one or more virtual objects is sensed. The delivery of the medical therapy is terminated immediately if the actuation of the one or more virtual objects corresponds to terminating the delivery of the medical therapy. The delivery of the medical therapy is initiated in a delayed manner if the actuation of the one or more virtual objects corresponds to starting the delivery of the medical therapy. A battery level of the electronic programmer is monitored. At least one of the following tasks is performed if the battery level is lower than a target battery level: disallowing programming of the electronic programmer; terminating the delivery of an existing medical therapy; and precluding the delivery of a prospective medical therapy.

摘要翻译： 一个或多个虚拟对象被显示在电子编程器上。 虚拟对象代表启动和终止向患者递送药物治疗。 感测到一个或多个虚拟对象的致动。 如果一个或多个虚拟物体的致动对应于终止药物治疗的递送，则立即终止药物治疗的递送。 如果一个或多个虚拟物体的致动对应于开始药物治疗的递送，则药物治疗的递送以延迟的方式开始。 监视电子编程器的电池电量。 如果电池电量低于目标电池电量，则执行以下任务中的至少一项：禁止电子编程器的编程; 终止现有医疗治疗的交付; 并排除了预期的药物治疗。

公开(公告)号：US20160296754A1

公开(公告)日：2016-10-13

申请号：US15186931

申请日：2016-06-20

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu ,  Michael Labbe

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/05

CPC分类号： A61N1/0558 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

摘要： A pulse generator is configured to generate electrical pulses of an electrical stimulation therapy. The pulse generator includes an N number of output channels and a microcontroller configured to generate instructions. The pulse generator is configured to generate different stimulation waveforms simultaneously for the output channels. The different waveforms have different waveform characteristics. A mesh electrode array includes an M number of electrodes. Each of the electrodes is configured to deliver the electrical pulses of the electrical stimulation therapy. M is at least several times greater than N. A solid state relay contains a plurality of controllable switches that is each configured to be turned on or off in response to the instructions received from the microcontroller, such that the solid state relay routes the output channels of the pulse generator to different subset of the electrodes of the mesh electrode array at different points in time.

摘要翻译： 脉冲发生器被配置为产生电刺激疗法的电脉冲。 脉冲发生器包括N个输出通道和被配置为产生指令的微控制器。 脉冲发生器被配置为为输出通道同时产生不同的刺激波形。 不同的波形具有不同的波形特性。 网状电极阵列包括M个电极。 每个电极被配置为递送电刺激治疗的电脉冲。 M比N大至少几倍。固态继电器包含多个可控开关，每个可控开关被配置为响应于从微控制器接收到的指令而导通或关断，使得固态继电器路由输出通道 的脉冲发生器到不同的时间点的网状电极阵列的电极的不同子集。

公开(公告)号：US10391321B2

公开(公告)日：2019-08-27

申请号：US15688454

申请日：2017-08-28

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu ,  Steven Siegel

IPC分类号： A61N1/00 ,  A61N1/372 ,  A61N1/36 ,  A61N1/05

摘要： A method of evaluating an implantation of a lead is disclosed. Via a graphical user interface of an electronic device, a visual representation of a sacrum of the patient and a lead that is implanted in the sacrum is displayed. The lead includes a plurality of electrode contacts. An evaluation is made as to how well the lead has been implanted in the sacrum based on the visual representation of the sacrum and the lead. The evaluating comprises: determining whether the lead is inserted in a predetermined region of the sacrum, determining how far a predetermined one of the electrode contacts is located from an edge of the sacrum, and determining a degree of curvature of the lead.

公开(公告)号：US10238877B2

公开(公告)日：2019-03-26

申请号：US15356772

申请日：2016-11-21

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu ,  Steven Siegel ,  Michele Spinelli

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61N1/372

摘要： An anal electrode device is configured to measure a response of a patient to a stimulation pulse. The anal electrode device includes an elongated shaft that is configured to be at least partially inserted into an anal canal of the patient. A first sensory electrode is disposed on a first region of the shaft. The first sensory electrode is configured to measure a compound motor action potential (CMAP) from an internal sphincter of the patient while the shaft is partially inserted into the anal canal of the patient. A second sensory electrode is disposed on a second region of the shaft. The second sensory electrode is configured to measure the CMAP from an external sphincter of the patient while the shaft is partially inserted into the anal canal of the patient.

公开(公告)号：US10080897B2

公开(公告)日：2018-09-25

申请号：US15610898

申请日：2017-06-01

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu ,  Michael Labbe

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/36132 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

摘要： A pulse generator is configured to generate electrical pulses of an electrical stimulation therapy. The pulse generator includes an N number of output channels and a microcontroller configured to generate instructions. The pulse generator is configured to generate different stimulation waveforms simultaneously for the output channels. The different waveforms have different waveform characteristics. A mesh electrode array includes an M number of electrodes. Each of the electrodes is configured to deliver the electrical pulses of the electrical stimulation therapy. M is at least several times greater than N. A solid state relay contains a plurality of controllable switches that is each configured to be turned on or off in response to the instructions received from the microcontroller, such that the solid state relay routes the output channels of the pulse generator to different subset of the electrodes of the mesh electrode array at different points in time.

公开(公告)号：US09895532B2

公开(公告)日：2018-02-20

申请号：US15229003

申请日：2016-08-04

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/0558 ,  A61N1/05 ,  A61N1/0512 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37235 ,  A61N1/37247

摘要： A medical system includes an implantable lead having a plurality of electrode contacts, a pulse generator coupled to the lead and configured to generate electrical pulses to be delivered to a patient through the plurality of electrode contacts, and an electronic programmer coupled to the pulse generator. The electronic programmer programs the pulse generator to generate the electrical pulses. The pulse generator is programmed to generate an electrical stimulation to be applied to the patient via one of the electrode contacts on the implantable lead. A determination is received as to whether the patient, in response to the electrical stimulation, exhibited a bellows response or a toes response. A stimulation parameter of the electrical stimulation is ramped up in response to a determination that the patient did not exhibit the bellows response or the toes response and that the patient did not feel pain in response to the electrical stimulation.

公开(公告)号：US09827424B2

公开(公告)日：2017-11-28

申请号：US14863469

申请日：2015-09-24

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu

IPC分类号： A61N1/36 ,  A61N1/372 ,  G06F19/00

CPC分类号： A61N1/36132 ,  A61N1/36071 ,  A61N1/36185 ,  A61N1/37247 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

摘要： A computer-assisted stimulation programming of an implantable medical device is performed. A perception threshold is determined for a plurality of contacts on a lead configured to be implanted inside a patient. The perception threshold is determined by automatically performing a first sweep of the plurality of contacts and automatically performing a second sweep of a stimulation parameter. A paresthesia coverage provided by the plurality of contacts is determined by automatically performing a third sweep of the plurality of contacts and automatically performing a fourth sweep of the stimulation parameter. The fourth sweep is performed based on the determined perception thresholds. The first sweep, the second sweep, the third sweep, and the fourth sweep are performed without needing a manual input from a human user. A subset of the contacts corresponding to the paresthesia coverage is selected. In response to user input, stimulation programming is performed using the subset of contacts.

公开(公告)号：US20170100602A1

公开(公告)日：2017-04-13

申请号：US15295218

申请日：2016-10-17

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu

IPC分类号： A61N1/372 ,  A61N1/05 ,  A61N1/36 ,  G06F19/00

CPC分类号： G16H50/50 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/37247 ,  G06F19/00 ,  G16H40/63

摘要： The present disclosure involves a medical system that includes one or more implantable medical devices configured to deliver a medical therapy to a patient. The medical system also includes a portable electronic device on which a touch-sensitive user interface is implemented. The user interface is configured to provide a visual representation of the medical therapy through a hierarchy. The hierarchy includes a lower level representation of the medical therapy that corresponds to a stimulation program that includes a plurality of configurable stimulation parameters. The hierarchy includes a middle level representation of the medical therapy that corresponds to a stimulation program-set that includes a plurality of different stimulation programs. The hierarchy includes an upper level representation of the medical therapy that corresponds to a scrollable collection of stimulation program-sets that are represented by a plurality of digital cards, respectively.

公开(公告)号：US20160361543A1

公开(公告)日：2016-12-15

申请号：US15044147

申请日：2016-02-16

申请人： Nuvectra Corporation

发明人： Norbert Kaula ,  Yohannes Iyassu

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36132 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/3605 ,  A61N1/36107 ,  A61N1/36185 ,  A61N1/37247 ,  A61N1/37264 ,  G06F19/00 ,  G06F19/3481 ,  G16H20/40 ,  G16H40/63

摘要： Feedback regarding electrical stimulation is provided to a patient. Electrical stimulation is applied to the patient. The electrical stimulation is applied by varying an electrical stimulation parameter. A signal is communicated to the patient via an electronic device. The signal is correlated with the electrical stimulation parameter such that the signal varies in association with the varying of the electrical stimulation parameter. The communicating is performed while the electrical stimulation is applied. Feedback is received from the patient in response to the electrical stimulation. Based on the received feedback from the patient, the electrical stimulation is adjusted.

摘要翻译： 向患者提供关于电刺激的反馈。 对患者施加电刺激。 通过改变电刺激参数来施加电刺激。 信号通过电子设备传送给患者。 信号与电刺激参数相关联，使得信号随着电刺激参数的变化而变化。 在施加电刺激的同时执行通信。 响应于电刺激从患者接收反馈。 根据患者的反馈信息，调整电刺激。