公开(公告)号：US20160051547A1

公开(公告)日：2016-02-25

申请号：US14836184

申请日：2015-08-26

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K31/496 ,  A61K9/16 ,  A61K9/00

CPC分类号： A61K9/0046 ,  A61K8/042 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1641 ,  A61K31/43 ,  A61K31/496 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036 ,  A61K47/02 ,  A61K47/10 ,  A61K47/34

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US09205048B2

公开(公告)日：2015-12-08

申请号：US14618926

申请日：2015-02-10

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K9/00 ,  A61K31/496 ,  A61K47/34

CPC分类号： A61K9/0046 ,  A61K8/042 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1641 ,  A61K31/43 ,  A61K31/496 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036 ,  A61K47/02 ,  A61K47/10 ,  A61K47/34

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或病症的组合物和方法，所述抗微生物剂组合物和制剂局部施用于患有耳科疾病或病症的个体 （s）。

公开(公告)号：US20150313839A1

公开(公告)日：2015-11-05

申请号：US14795825

申请日：2015-07-09

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Benedikt Vollrath ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K9/00 ,  A61K31/4535 ,  A61K47/10

CPC分类号： A61K31/517 ,  A61K9/0046 ,  A61K31/135 ,  A61K31/137 ,  A61K31/4535 ,  A61K31/47 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开了用于治疗耳科疾病或病症的组合物和方法，其中耳蜗感觉细胞调节剂组合物和制剂在局部施用于患有耳科疾病或病症的个体，通过将这些组合物和制剂直接施用于或经由灌注至 目标耳结构。

公开(公告)号：US20140364403A1

公开(公告)日：2014-12-11

申请号：US14300030

申请日：2014-06-09

申请人： OTONOMY, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Michael Christopher Scaife ,  Benedikt Vollrath ,  Sergio G. Duron ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K31/573

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。

公开(公告)号：US20140309217A1

公开(公告)日：2014-10-16

申请号：US14300011

申请日：2014-06-09

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Michael Christopher Scaife ,  Benedikt Vollrath ,  Sergio G. Duron ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K9/00 ,  A61K31/167 ,  A61K31/197 ,  A61K31/5513

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/00 ,  A61K31/167 ,  A61K31/195 ,  A61K31/197 ,  A61K31/5513 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  A61K2300/00

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开的是通过将CNS调节剂组合物和组合物局部施用于患有耳科疾病的个体，通过将这些组合物和组合物直接施用到或经由灌注到目标耳结构中来治疗耳部疾病的组合物和方法， 。

公开(公告)号：US10918594B2

公开(公告)日：2021-02-16

申请号：US16447776

申请日：2019-06-20

申请人： OTONOMY, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Michael Christopher Scaife ,  Benedikt Vollrath ,  Sergio G. Duron ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61F9/02 ,  A61K9/00 ,  A61K9/06 ,  A61K31/167 ,  A61K31/195 ,  A61K31/5513 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  A61K31/00 ,  A61K31/197

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US10232044B2

公开(公告)日：2019-03-19

申请号：US14465153

申请日：2014-08-21

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Michael Christopher Scaife ,  Benedikt Vollrath ,  Sergio G. Duron ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K31/724 ,  A61K47/34 ,  A61K9/14 ,  A61K31/5377 ,  A61K31/5517

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US09867778B2

公开(公告)日：2018-01-16

申请号：US14741092

申请日：2015-06-16

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K9/00 ,  A61K47/34 ,  A61K31/496 ,  A61K9/10 ,  A61K47/02 ,  A61K47/10 ,  A61K9/16 ,  A61K9/06 ,  A61K31/43 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036 ,  A61K8/04 ,  A61K9/14

CPC分类号： A61K9/0046 ,  A61K8/042 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1641 ,  A61K31/43 ,  A61K31/496 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036 ,  A61K47/02 ,  A61K47/10 ,  A61K47/34

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US09744126B2

公开(公告)日：2017-08-29

申请号：US14300030

申请日：2014-06-09

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K9/06 ,  A61K47/10 ,  A61K45/06

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US09603796B2

公开(公告)日：2017-03-28

申请号：US14836184

申请日：2015-08-26

申请人： Otonomy, Inc. ,  The Regents of the University of California

发明人： Jay Lichter ,  Andrew M. Trammel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Jeffrey P. Harris

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K9/06 ,  A61K9/14 ,  A61K8/04 ,  A61K47/34 ,  A61K31/496 ,  A61K47/02 ,  A61K47/10 ,  A61K31/43 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036

CPC分类号： A61K9/0046 ,  A61K8/042 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1641 ,  A61K31/43 ,  A61K31/496 ,  A61K31/522 ,  A61K31/573 ,  A61K31/7036 ,  A61K47/02 ,  A61K47/10 ,  A61K47/34

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).