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公开(公告)号：US08399482B2
公开(公告)日：2013-03-19
申请号：US12970376
申请日：2010-12-16
IPC分类号： A61K31/4725 , C07D217/24 , C07D405/12
CPC分类号： C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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22.发明申请公开(公告)号：US20110190340A1
公开(公告)日：2011-08-04
申请号：US13000202
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D217/24 , A61K31/472 , A61P9/12 , A61P9/10 , A61P13/12 , A61P35/00 , A61P25/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
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23.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07666848B2
公开(公告)日：2010-02-23
申请号：US11464338
申请日：2006-08-14
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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24.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07101856B2
公开(公告)日：2006-09-05
申请号：US10616945
申请日：2003-07-11
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I: in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理上耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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25.发明授权Polymorphs of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride 有权6-（哌啶-4-基氧基）-2H-异喹啉-1-酮盐酸盐的多晶型物公开(公告)号：US08598201B2
公开(公告)日：2013-12-03
申请号：US13534910
申请日：2012-06-27
申请人： Norbert Nagel , Bruno Baumgartner , Harald Berchtold , Oliver Plettenburg , Dieter Kadereit , Mandy Mohnicke , Simon Gessler , Joachim Tillner
发明人： Norbert Nagel , Bruno Baumgartner , Harald Berchtold , Oliver Plettenburg , Dieter Kadereit , Mandy Mohnicke , Simon Gessler , Joachim Tillner
IPC分类号： C07D401/12 , A61K31/4725
CPC分类号： C07D401/12
摘要： The present invention relates to new crystalline polymorphs of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and their use, in particular for the preparation of medicaments.
摘要翻译： 本发明涉及6-（哌啶-4-基氧基）-2H-异喹啉-1-酮盐酸盐的新结晶多晶型物，其制备及其用途，特别是制备药物的方法。
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26.发明申请公开(公告)号：US20110190341A1
公开(公告)日：2011-08-04
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： A61K31/472 , C07D217/24 , A61P9/12 , A61P9/10 , A61P25/00 , A61P13/12 , A61P11/00 , A61P35/00 , A61P25/28
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
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27.发明申请CRYSTALLINE SOLVATES OF 6-(PIPERIDIN-4-YLOXY)-2H-ISOQUINOLIN-1-ONE HYDROCHLORIDE 审中-公开6-（哌啶-4-基锂）-2H-异喹啉-1-酮氢氯化物的晶体溶剂公开(公告)号：US20140221656A1
公开(公告)日：2014-08-07
申请号：US14245451
申请日：2014-04-04
申请人： Norbert Nagel , Bruno Baumgartner , Harald Berchtold , Oliver Plettenburg , Dieter Kadereit , Mandy Mohnicke , Simon Gessler , Joachim Tillner
发明人： Norbert Nagel , Bruno Baumgartner , Harald Berchtold , Oliver Plettenburg , Dieter Kadereit , Mandy Mohnicke , Simon Gessler , Joachim Tillner
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , A61K31/4725
摘要： The present invention relates to crystalline solvates of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and the use thereof.
摘要翻译： 本发明涉及6-（哌啶-4-基氧基）-2H-异喹啉-1-酮盐酸盐的结晶溶剂合物，其制备及其用途。
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28.发明授权公开(公告)号：US08716481B2
公开(公告)日：2014-05-06
申请号：US12817591
申请日：2010-06-17
申请人： Kai Rossen , Hermut Wehlan , Oliver Plettenburg , Volker Kraft , Guenter Billen , Simon Gessler
发明人： Kai Rossen , Hermut Wehlan , Oliver Plettenburg , Volker Kraft , Guenter Billen , Simon Gessler
IPC分类号： C07D217/24
CPC分类号： C07D401/12 , C07D205/04 , C07D207/12 , C07D211/42 , C07D211/46
摘要： The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.
摘要翻译： 本发明涉及制备式（I）的6-取代-1-（2H） - 异喹啉酮衍生物的方法，其中R 1和n如说明书中所述。 本发明还涉及用于本发明方法的新型中间体和制备这种中间体的方法。
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29.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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30.发明授权公开(公告)号：US08541449B2
公开(公告)日：2013-09-24
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： C07D217/24 , A61K31/472
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
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