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1.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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公开(公告)号：US08748614B2
公开(公告)日：2014-06-10
申请号：US12487455
申请日：2009-06-18
IPC分类号： A61K31/535 , C07D217/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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3.发明申请公开(公告)号：US20100056568A1
公开(公告)日：2010-03-04
申请号：US12487525
申请日：2009-06-18
IPC分类号： A61K31/47 , C07D217/22 , C07D217/24
CPC分类号： C07D217/22 , C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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公开(公告)号：US08772492B2
公开(公告)日：2014-07-08
申请号：US12487409
申请日：2009-06-18
IPC分类号： A61K31/47 , C07D217/00 , C07D401/12 , C07D451/06 , C07D405/14 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉衍生物， 化合物。
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5.发明授权4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基 - 氧基或巯基取代的羧酸，其生产和使用方法作为药物公开(公告)号：US07709494B2
公开(公告)日：2010-05-04
申请号：US12267925
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/34 , A61K31/513
CPC分类号： C07D239/34
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n, V, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，m，n，V，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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6.发明授权4,5-diphenyl-pyrimidinyl substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基取代的羧酸，其制备方法和用作药物公开(公告)号：US07709490B2
公开(公告)日：2010-05-04
申请号：US12267912
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/26 , A61K31/505
CPC分类号： C07D239/26
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，m，n和X如本文所定义，或其生理学上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放的用途。
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7.发明授权Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticals 有权二芳基环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07160911B2
公开(公告)日：2007-01-09
申请号：US10789019
申请日：2004-02-27
申请人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： A61K31/421 , A61K31/422 , C07D263/34 , C07D413/02 , C07D413/04
CPC分类号： C07D263/32
摘要： Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticalsThe invention relates to diarylcycloalkyl derivatives and to their physiologically acceptable salts, racemates and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 二芳基环烷基衍生物，其制备方法及其作为药物的用途本发明涉及二芳基环烷基衍生物及其生理学上可接受的盐，外消旋体和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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8.发明授权Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07872034B2
公开(公告)日：2011-01-18
申请号：US12013806
申请日：2008-01-14
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/421 , C07D263/32 , A61P3/10
CPC分类号： C07D263/32 , C07D413/02
摘要： The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.
摘要翻译： 本发明涉及芳基环烷基取代的链烷酸衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物例如适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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9.发明授权1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator activated receptor delta modulators and their use in the treatment of neurological and metabolic disease 失效1,3,4-恶二唑-2-酮作为过氧化物酶体增殖物激活受体δ调节剂及其在治疗神经和代谢疾病中的应用公开(公告)号：US07638539B2
公开(公告)日：2009-12-29
申请号：US11535764
申请日：2006-09-27
申请人： Daniel G. McGarry , Jochen Goerlitzer , Stefanie Keil , Karen Chandross , Jean Merrill , Wolfgang Wendler
发明人： Daniel G. McGarry , Jochen Goerlitzer , Stefanie Keil , Karen Chandross , Jean Merrill , Wolfgang Wendler
IPC分类号： A61K31/4245 , A61K31/427 , C07D271/113 , C07D277/20
CPC分类号： C07D417/12 , C07D277/24 , C07D277/30
摘要： The present invention is directed to 1,3,4-oxadiazalones, i.e., the compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein. The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization such as multiple scleroses.
摘要翻译： 本发明涉及1,3,4-恶二唑酮，即式I化合物及其药学上可接受的盐，立体异构体，互变异构体或溶剂合物。 新型化合物包括式I化合物，其中基团如本文所定义。 本发明的化合物是PPARdta的调节剂，因此可用作药剂，特别是用于治疗脱髓鞘疾病和脂肪酸代谢紊乱以及葡萄糖利用如多种硬化症。
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10.发明授权Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07365084B2
公开(公告)日：2008-04-29
申请号：US10788997
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07D413/02 , C07D263/30 , A61K31/4439 , A61K31/422
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals.
摘要翻译： 本文提供环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途。
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