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1.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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2.发明申请公开(公告)号：US20100056553A1
公开(公告)日：2010-03-04
申请号：US12487503
申请日：2009-06-18
申请人： Oliver PLETTENBURG , Katrin LORENZ , Jochen GOERLITZER , Matthias Löhn , Sandrine BISCARRAT , Fréderic JEANNOT , Olivier DUCLOS
发明人： Oliver PLETTENBURG , Katrin LORENZ , Jochen GOERLITZER , Matthias Löhn , Sandrine BISCARRAT , Fréderic JEANNOT , Olivier DUCLOS
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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公开(公告)号：US20100056566A1
公开(公告)日：2010-03-04
申请号：US12487409
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D401/02
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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4.发明申请公开(公告)号：US20100056568A1
公开(公告)日：2010-03-04
申请号：US12487525
申请日：2009-06-18
IPC分类号： A61K31/47 , C07D217/22 , C07D217/24
CPC分类号： C07D217/22 , C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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公开(公告)号：US08748614B2
公开(公告)日：2014-06-10
申请号：US12487455
申请日：2009-06-18
IPC分类号： A61K31/535 , C07D217/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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公开(公告)号：US20100056518A1
公开(公告)日：2010-03-04
申请号：US12487479
申请日：2009-06-18
申请人： Oliver PLETTENBURG , Armin HOFMEISTER , Katrin LORENZ , Joachim BRENDEL , Matthias Löhn , John Weston
发明人： Oliver PLETTENBURG , Armin HOFMEISTER , Katrin LORENZ , Joachim BRENDEL , Matthias Löhn , John Weston
IPC分类号： A61K31/5377 , C07D217/22 , A61K31/47 , C07D413/02 , C07D403/02 , A61K31/496 , A61P9/00 , A61P25/00 , A61P37/00 , A61P3/00
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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公开(公告)号：US08742116B2
公开(公告)日：2014-06-03
申请号：US12487479
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
发明人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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公开(公告)号：US08710228B2
公开(公告)日：2014-04-29
申请号：US12487386
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Stefan Peukert , Sven Ruf , Matthias Löhn , Peter Monecke , Alexander Schiffer , Aimo Kannt , Markus Kohlmann
发明人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Stefan Peukert , Sven Ruf , Matthias Löhn , Peter Monecke , Alexander Schiffer , Aimo Kannt , Markus Kohlmann
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹啉衍生物和含有这些化合物的组合物。
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公开(公告)号：US20120316152A1
公开(公告)日：2012-12-13
申请号：US13586468
申请日：2012-08-15
IPC分类号： A61K31/4725 , A61P9/12 , A61P27/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P1/16 , A61P13/12 , A61P11/06 , A61P11/00 , A61P7/02 , A61P25/00 , A61P29/00 , A61P25/28 , A61P15/00 , A61P5/00 , A61P3/10 , A61P3/00 , A61P31/04 , A61P31/00 , A61P35/00 , A61P19/08 , A61P37/00 , A61K31/55
CPC分类号： C07D401/12 , C07D401/14
摘要： A method for the treatment or prevention in a mammal of a disease associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase comprising administering to the mammal in need thereof at least one compound of the formula (I)
摘要翻译： 一种用于治疗或预防哺乳动物与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的方法，其包括向有需要的哺乳动物施用至少一种式（I）化合物，
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10.发明申请Substituted isoquinoline and isoquinolinone derivatives as inhibitors of RHO-Kinase 有权取代的异喹啉和异喹啉酮衍生物作为RHO-激酶的抑制剂公开(公告)号：US20100063025A1
公开(公告)日：2010-03-11
申请号：US12487403
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D401/12 , C07D401/14 , A61K31/55 , A61P9/12 , A61P11/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P1/16 , A61P3/10 , A61P3/00 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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