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    SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES
    23.
    发明申请
    SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES 有权
    取代的杂芳基吡咯烷酮衍生物

    公开(公告)号：US20090306088A1

    公开(公告)日：2009-12-10

    申请号：US12487270

    申请日：2009-06-18

    申请人： Aude FAYOL ,  Thierry GALLET ,  Alistair LOCHEAD ,  Mourad SAADY ,  Corinne VERONIQUE ,  Philippe YAICHE

    发明人： Aude FAYOL ,  Thierry GALLET ,  Alistair LOCHEAD ,  Mourad SAADY ,  Corinne VERONIQUE ,  Philippe YAICHE

    IPC分类号： A61K31/519 ,  C07D471/04 ,  A61P25/00

    CPC分类号： A01N43/90 ,  C07D239/70

    摘要： A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof are disclosed and claimed. Wherein m, n, o, Y, Z, R1, R2, R3, R4, R5 R6 and R7 are as described herein. Also disclosed are the salts of compounds of formula (I). The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

    摘要翻译： 公开并要求保护由式（I）表示的嘧啶酮衍生物或其盐，或其溶剂合物或其水合物。 其中m，n，o，Y，Z，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所述。 还公开了式（I）化合物的盐。 本发明还涉及包含所述衍生物或其盐作为活性成分的药物，所述活性成分用于预防和/或治疗由GSK3β如阿尔茨海默病异常活动引起的神经变性疾病。

    HETEROARYL SUBSTITUTED 2-PYRIDINYL AND 2-PYRIMIDINYL -6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES
    26.
    发明申请
    HETEROARYL SUBSTITUTED 2-PYRIDINYL AND 2-PYRIMIDINYL -6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES 失效
    异噻唑基取代的2-吡啶基和2-吡啶基-6,7,8,9-四氢吡啶并[1,2-a]嘧啶-4-酮衍生物

    公开(公告)号：US20070225300A1

    公开(公告)日：2007-09-27

    申请号：US11749349

    申请日：2007-05-16

    申请人： Alistair LOCHEAD ,  Alain NEDELEC ,  Mourad SAADY ,  Philippe YAICHE

    发明人： Alistair LOCHEAD ,  Alain NEDELEC ,  Mourad SAADY ,  Philippe YAICHE

    IPC分类号： A61K31/519

    CPC分类号： A61K31/519 ,  A01N43/90 ,  C07D487/04

    摘要： The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X, Y, R1, R2, R3, R4, R5, m, n and p are as defined herein. In particular, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β or GSK3β and cdk5/p25, such as Alzheimer disease.

    摘要翻译： 本发明涉及由式（I）表示的嘧啶酮衍生物或其盐，其中：X，Y，R 1，R 2，R 3，R 4，R 5，m，n和p如本文所定义。 特别地，本发明涉及包含所述衍生物或其盐作为活性成分的药物，其用于预防和/或治疗由GSK3β或GSK3β和cdk5 / p25的异常活性引起的神经变性疾病的预防和/或治疗，例如 阿尔茨海默病。