SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES
    3.
    发明申请
    SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES 有权
    取代的杂芳基吡咯烷酮衍生物

    公开(公告)号:US20090306088A1

    公开(公告)日:2009-12-10

    申请号:US12487270

    申请日:2009-06-18

    CPC分类号: A01N43/90 C07D239/70

    摘要: A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof are disclosed and claimed. Wherein m, n, o, Y, Z, R1, R2, R3, R4, R5 R6 and R7 are as described herein. Also disclosed are the salts of compounds of formula (I). The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

    摘要翻译: 公开并要求保护由式(I)表示的嘧啶酮衍生物或其盐,或其溶剂合物或其水合物。 其中m,n,o,Y,Z,R 1,R 2,R 3,R 4,R 5,R 6和R 7如本文所述。 还公开了式(I)化合物的盐。 本发明还涉及包含所述衍生物或其盐作为活性成分的药物,所述活性成分用于预防和/或治疗由GSK3β如阿尔茨海默病异常活动引起的神经变性疾病。