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70 条记录 (耗时 0.038 秒)

    Injectable drug delivery system and method
    22.
    发明授权
    Injectable drug delivery system and method 失效
    注射药物递送系统及方法

    公开(公告)号：US5783205A

    公开(公告)日：1998-07-21

    申请号：US843682

    申请日：1997-04-10

    申请人： Randall G. Berggren ,  David J. Enscore ,  Susan M. Marks ,  James L. Osborne ,  Patrick S.-L. Wong ,  Wouter E. Roorda

    发明人： Randall G. Berggren ,  David J. Enscore ,  Susan M. Marks ,  James L. Osborne ,  Patrick S.-L. Wong ,  Wouter E. Roorda

    IPC分类号： A61C19/06 ,  A61K6/00 ,  A61K9/00 ,  A61K9/22 ,  A61K47/34 ,  A61F2/02

    CPC分类号： A61C19/063 ,  A61K6/0067 ,  A61K9/0063 ,  A61K47/34

    摘要： The present invention is directed to a material which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket, such as a periodontal pocket. The material is preferably a bioerodible oligomer or polymer. The oligomer or polymer containing the drug is heated and is then delivered, preferably by injection, into the tissue pocket at a physiologically compatible elevated temperature. Once the bioerodible material is injected into the pocket, the material cools to the body temperature of the pocket. As it cools, the material hardens and remains in place in the tissue pocket. The hardened material bioerodes in the pocket and releases the drug over a period of several days.

    摘要翻译： 本发明涉及可用于将诸如抗生素的药物递送到患病组织袋（例如牙周袋）中的材料。 该材料优选为生物可腐蚀的低聚物或聚合物。 包含药物的低聚物或聚合物被加热，然后优选通过注射递送到生理上相容的升高的温度下的组织袋中。 一旦将生物可蚀解材料注入到口袋中，则该材料冷却到口袋的体温。 当它冷却时，材料硬化并保持在组织袋中的适当位置。 硬化的材料在口袋中传播并在几天的时间内释放药物。

    Solid formulations of therapeutic proteins for gastrointestinal delivery
    24.
    发明授权
    Solid formulations of therapeutic proteins for gastrointestinal delivery 失效
    用于胃肠道输送的治疗性蛋白质的固体制剂

    公开(公告)号：US5424289A

    公开(公告)日：1995-06-13

    申请号：US99884

    申请日：1993-07-30

    申请人： Heechung Yang ,  Vu A. Nguyen ,  Liang C. Dong ,  Patrick S.-L. Wong

    发明人： Heechung Yang ,  Vu A. Nguyen ,  Liang C. Dong ,  Patrick S.-L. Wong

    IPC分类号： A61K9/16 ,  A61K38/27 ,  A61K38/28 ,  A61K47/12 ,  A61K47/44 ,  A61K38/00

    CPC分类号： A61K38/27 ,  A61K38/28 ,  A61K47/12 ,  A61K47/44 ,  A61K9/1617

    摘要： The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.

    摘要翻译： 本发明涉及治疗性多肽的药物制剂以及水杨酸钠和油的渗透增强混合物，以在口服给药之后通过胃肠道壁，特别是结肠壁提供增强的多肽吸收 ，油的量为总制剂的约10重量％至约30重量％，优选约15重量％至约25重量％，水杨酸钠的量为约70重量％至约90重量％ ，优选约75重量％至约85重量％。 多肽可以是非冻干的。 药物制剂的特征在于固体，其提供用于处理和储存的方便和改进的形式，以及用于制备含有均匀成分混合物的口服剂型（例如丸剂，胶囊和递送容器）。

    Oral osmotic device with hydrogel driving member
    26.
    发明授权
    Oral osmotic device with hydrogel driving member 失效
    具有水凝胶驱动构件的口腔渗透装置

    公开(公告)号：US5248310A

    公开(公告)日：1993-09-28

    申请号：US859191

    申请日：1992-03-27

    申请人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri D. Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    发明人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri D. Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译： 公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。 装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。 装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层 可溶胀的亲水性聚合物。 壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。 所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。 在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。 壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。 标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。