公开(公告)号：US08173392B2

公开(公告)日：2012-05-08

申请号：US11978156

申请日：2007-10-26

申请人： Peter G. Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason W. Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

发明人： Peter G. Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason W. Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

IPC分类号： C12N1/20 ,  C12N1/14 ,  C12N1/12

CPC分类号： C12P21/00 ,  C07K14/00 ,  C07K14/505 ,  C12N9/93 ,  C12N15/67 ,  C12P13/00 ,  C12P13/005 ,  C12P13/04 ,  C12P13/22 ,  C12P19/26 ,  C12P21/02

摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

公开(公告)号：US08030074B2

公开(公告)日：2011-10-04

申请号：US11978108

申请日：2007-10-26

申请人： Peter G. Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason W. Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

发明人： Peter G. Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason W. Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

IPC分类号： C12N15/63 ,  C12N15/87 ,  C07K7/00

CPC分类号： C12P21/00 ,  C07K14/00 ,  C07K14/505 ,  C12N9/93 ,  C12N15/67 ,  C12P13/00 ,  C12P13/005 ,  C12P13/04 ,  C12P13/22 ,  C12P19/26 ,  C12P21/02

摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。

公开(公告)号：US07834159B2

公开(公告)日：2010-11-16

申请号：US11580203

申请日：2006-10-11

申请人： Peter G. Schultz ,  Lei Wang ,  Zhiwen Zhang

发明人： Peter G. Schultz ,  Lei Wang ,  Zhiwen Zhang

IPC分类号： C07K14/00 ,  A61K38/00

CPC分类号： C12P21/005

摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

摘要翻译： 提供在体外和体内制备糖蛋白的方法。 一种方法包括将非天然氨基酸掺入蛋白质并将一个或多个糖部分连接到非天然氨基酸上。 另一种方法包括将包含糖部分的非天然氨基酸掺入蛋白质中。 通过两种方法制备的蛋白质可以用额外的糖进一步修饰。

公开(公告)号：US07825226B2

公开(公告)日：2010-11-02

申请号：US11978232

申请日：2007-10-26

申请人： Peter G. Schultz ,  Lei Wang ,  Zhiwen Zhang

发明人： Peter G. Schultz ,  Lei Wang ,  Zhiwen Zhang

IPC分类号： C07K14/00 ,  A61K38/16

CPC分类号： C12P21/005

摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

公开(公告)号：US20080261311A1

公开(公告)日：2008-10-23

申请号：US11978108

申请日：2007-10-26

申请人： Peter Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason William Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan A. Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

发明人： Peter Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason William Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan A. Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

IPC分类号： C12N15/63 ,  C12N15/87 ,  C12N15/82 ,  C07K7/00 ,  C07K14/00

CPC分类号： C12P21/00 ,  C07K14/00 ,  C07K14/505 ,  C12N9/93 ,  C12N15/67 ,  C12P13/00 ,  C12P13/005 ,  C12P13/04 ,  C12P13/22 ,  C12P19/26 ,  C12P21/02

摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

公开(公告)号：US20080167243A1

公开(公告)日：2008-07-10

申请号：US11978188

申请日：2007-10-26

申请人： Peter Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason William Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

发明人： Peter Schultz ,  Lei Wang ,  John Christopher Anderson ,  Jason William Chin ,  David R. Liu ,  Thomas J. Magliery ,  Eric L. Meggers ,  Ryan Aaron Mehl ,  Miro Pastrnak ,  Stephen William Santoro ,  Zhiwen Zhang

IPC分类号： A61K38/00

CPC分类号： C12P21/00 ,  C07K14/00 ,  C07K14/505 ,  C12N9/93 ,  C12N15/67 ,  C12P13/00 ,  C12P13/005 ,  C12P13/04 ,  C12P13/22 ,  C12P19/26 ,  C12P21/02

摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

公开(公告)号：US20050233412A1

公开(公告)日：2005-10-20

申请号：US11093597

申请日：2005-03-29

申请人： Peter Schultz ,  Lei Wang ,  Zhiwen Zhang

发明人： Peter Schultz ,  Lei Wang ,  Zhiwen Zhang

IPC分类号： A61K38/14 ,  A61K38/16 ,  C07K9/00 ,  C07K14/00 ,  C07K14/47 ,  C12N9/10 ,  C12P19/00 ,  C12P21/00 ,  C12P21/06

CPC分类号： C12P21/005

摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

公开(公告)号：US20050209133A1

公开(公告)日：2005-09-22

申请号：US11093797

申请日：2005-03-29

申请人： Peter Schultz ,  Lei Wang ,  Zhiwen Zhang

发明人： Peter Schultz ,  Lei Wang ,  Zhiwen Zhang

IPC分类号： A61K38/14 ,  A61K38/16 ,  C07K9/00 ,  C07K14/00 ,  C07K14/47 ,  C12N9/10 ,  C12P19/00 ,  C12P21/00 ,  C12P21/06

CPC分类号： C12P21/005

摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

公开(公告)号：US20050186657A1

公开(公告)日：2005-08-25

申请号：US11094676

申请日：2005-03-29

申请人： Peter Schultz ,  Lei Wang ,  Zhiwen Zhang

发明人： Peter Schultz ,  Lei Wang ,  Zhiwen Zhang

IPC分类号： A61K38/14 ,  A61K38/16 ,  C07K9/00 ,  C07K14/00 ,  C07K14/47 ,  C12N9/10 ,  C12P19/00 ,  C12P21/00 ,  C12P21/06

CPC分类号： C12P21/005

摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

公开(公告)号：US06927042B2

公开(公告)日：2005-08-09

申请号：US10686944

申请日：2003-10-15

申请人： Peter G. Schultz ,  Lei Wang ,  Zhiwen Zhang

发明人： Peter G. Schultz ,  Lei Wang ,  Zhiwen Zhang

IPC分类号： A61K38/14 ,  A61K38/16 ,  C07K9/00 ,  C07K14/00 ,  C07K14/47 ,  C12N9/10 ,  C12P19/00 ,  C12P21/00 ,  C12P21/06

CPC分类号： C12P21/005

摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

摘要翻译： 提供在体外和体内制备糖蛋白的方法。 一种方法包括将非天然氨基酸掺入蛋白质并将一个或多个糖部分连接到非天然氨基酸上。 另一种方法包括将包含糖部分的非天然氨基酸掺入蛋白质中。 通过两种方法制备的蛋白质可以用额外的糖进一步修饰。