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    HIGH-FREQUENCY ELECTROPORATION FOR CANCER THERAPY
    21.
    发明申请
    HIGH-FREQUENCY ELECTROPORATION FOR CANCER THERAPY 审中-公开
    用于癌症治疗的高频电泳

    公开(公告)号：US20120109122A1

    公开(公告)日：2012-05-03

    申请号：US13332133

    申请日：2011-12-20

    申请人： Christopher B. ARENA ,  Rafael V. Davalos ,  Michael B. Sano

    发明人： Christopher B. ARENA ,  Rafael V. Davalos ,  Michael B. Sano

    IPC分类号： A61B18/00

    CPC分类号： A61B18/14 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61N1/327

    摘要： The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

    摘要翻译： 本发明涉及疾病和病症的生物医学工程和医学治疗领域。 提供了体内治疗细胞增殖性疾病的方法，装置和系统。 在实施例中，这些方法包括输送高频脉冲串的双极脉冲以实现所需的细胞死亡模式。 更具体地，本发明的实施例涉及使用高频双极电脉冲来破坏包括肿瘤组织的异常细胞的装置和方法，所述高频双极电脉冲具有微秒级的微秒级和单极性的持续时间，微秒至纳秒级 。 在实施方案中，所述方法依赖于常规电穿孔辅助药物或不可逆电穿孔以在治疗的肿瘤中引起细胞死亡。 本发明可用于治疗诸如脑肿瘤的实体瘤。

    DIELECTROPHORESIS METHODS FOR DETERMINING A PROPERTY OF A PLURALITY OF CANCER CELLS
    23.
    发明申请
    DIELECTROPHORESIS METHODS FOR DETERMINING A PROPERTY OF A PLURALITY OF CANCER CELLS 审中-公开
    用于确定多种癌细胞的性质的电化学方法

    公开(公告)号：US20140339088A1

    公开(公告)日：2014-11-20

    申请号：US14449050

    申请日：2014-07-31

    申请人： Eva M. Schmelz ,  Elizabeth S. Elvington ,  Alireza Salmanzadeh ,  Mike Sano ,  Paul C. Roberts ,  Rafael V. Davalos

    发明人： Eva M. Schmelz ,  Elizabeth S. Elvington ,  Alireza Salmanzadeh ,  Mike Sano ,  Paul C. Roberts ,  Rafael V. Davalos

    IPC分类号： G01N33/487 ,  G01N27/447 ,  G01N33/50

    CPC分类号： G01N33/48735 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/44704 ,  G01N33/5011 ,  G01N33/5023

    摘要： Provided are dielectrophoresis (DEP) devices and methods that allow cell sorting to identify, isolate, and/or separate cells of interest based on electrical and physical properties of the cells. Particularly, provided are systems and methods for manipulating particles suspended in a fluid, e.g., cells, micro- or nano-particles, using their electrical signatures. Such methods can be performed using DEP, iDEP, and/or cDEP (contactless dielectrophoresis, where direct contact between the electrodes and the sample is avoided). Typically, an electric field is induced in a sample comprising the target particles and/or cells, such as cancer cells, and the spatial distribution of cells is measured to identify one or more characteristics or properties of the cancer cells. The identified characteristics of the sorted cells can be used to determine drug efficacy and/or resistance with respect to the cells.

    摘要翻译： 提供的是介电电泳（DEP）装置和方法，其允许细胞分选基于细胞的电学和物理性质鉴定，分离和/或分离感兴趣的细胞。 特别地，提供了使用其电特征来操纵悬浮在流体中的颗粒（例如，细胞，微米或纳米颗粒）的系统和方法。 可以使用DEP，iDEP和/或cDEP（非接触式介电电泳，其中避免了电极和样品之间的直接接触）来执行这些方法。 通常，在包含靶颗粒和/或细胞（例如癌细胞）的样品中诱导电场，并且测量细胞的空间分布以鉴定癌细胞的一个或多个特征或性质。 分选的细胞的鉴定特征可用于确定相对于细胞的药物功效和/或抗性。