Surface-Enhanced Spectroscopy with Implanted Biosensors
    22.
    发明申请
    Surface-Enhanced Spectroscopy with Implanted Biosensors 审中-公开
    表面增强光谱与植入生物传感器

    公开(公告)号:US20080214913A1

    公开(公告)日:2008-09-04

    申请号:US11816534

    申请日:2006-02-16

    IPC分类号: A61B5/1455 A61B5/00

    摘要: The present invention provides a spectroscopic apparatus, a method and a computer program product for determining the concentration of an analyte of a fluid that flows through a capillary vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for determining the position of at least one biosensing substrate that has been implanted into the biological sample in the proximity of the capillary vessel but outside the capillary vessel. The biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the vessel wall of the capillary vessel is at least semi-permeable. By performing a spectroscopic analysis not directly inside the capillary vessel but in close proximity to the capillary vessel, the signal-to-noise ratio of the spectroscopic signals obtained can be appreciably enhanced while disadvantageous scattering and interference effects can be minimized.

    摘要翻译: 本发明提供一种用于确定流过生物样品的毛细血管的流体的分析物的浓度的光谱仪,方法和计算机程序产品。 分光装置利用成像系统来确定在毛细血管附近但在毛细血管附近植入生物样品中的至少一个生物传感基片的位置。 生物传感底物能够诱导表面增强的光谱效应,并且优选地适于可逆地和选择性地结合毛细血管的血管壁至少半透性的某些分析物或流体分子。 通过不是直接在毛细血管内部进行光谱分析,而是靠近毛细血管,所获得的光谱信号的信噪比可以明显增强,而不利的散射和干涉效应可以最小化。

    Optical record carrier
    23.
    发明申请
    Optical record carrier 审中-公开
    光记录载体

    公开(公告)号:US20060280106A1

    公开(公告)日:2006-12-14

    申请号:US10568370

    申请日:2004-08-12

    IPC分类号: G11B7/24

    摘要: The range of spatial frequencies of the information areas in an optical record carrier (130) that can be read by conventional means can be increased substantially by providing the information layer (1134) with a birefringent diffraction grating (136) and using a read beam (b) that comprises two mutually perpendicular polarised components (b1, b2) only one of which will be diffracted by the grating.

    摘要翻译: 可以通过向信息层(1134)提供双折射衍射光栅(136)并使用读取光束(136)来大大增加可以通过传统手段读取的光学记录载体(130)中的信息区域的空间频率的范围 b)包括两个相互垂直的极化分量(b 1,B 2 2),其中仅一个将被光栅衍射。

    Radiation emitting semiconductor device and method of manufacturing such a device

    公开(公告)号:US20060043381A1

    公开(公告)日:2006-03-02

    申请号:US10534385

    申请日:2003-10-31

    IPC分类号: H01L33/00 H01L21/00

    CPC分类号: H01L33/34 H01L27/15

    摘要: Radiation-emitting semiconductor device and method of manufacturing such a device. The invention relates to a radiation-emitting semiconductor device (10) comprising a silicon-containing semiconductor body (1) and a substrate (2), which semiconductor body (1) comprises a lateral semiconductor diode positioned on an insulating layer (7) which separates the diode from the substrate (2). The lateral semiconductor diode comprises a first semiconductor region (3) of a first conductivity type and with a first doping concentration, a second semiconductor region (4) of the first or a second conductivity type opposite to the first conductivity type and with a second doping concentration which is lower than the first doping concentration, and a third semiconductor region (5) of the second conductivity type and with a third doping concentration which is higher than the second doping concentration, the first and the third region (3, 5) each being provided with a connection region (6, 8), and, during operation, radiation (S) being generated in the second region (4) due to recombination of charge carriers injected therein from the first and the third region (3, 5). According to the invention, the second semiconductor region (4) comprises a central part (4A) which is surrounded by a further part (4B) the bandgap of which is larger than the bandgap of the central part (4A). In this way, the radiation yield is increased in an indirect semiconductor material such as silicon in the central part (4A) as translation of the relatively long-living charge carriers towards a non-radiative recombination center is limited because of the barriers in the valence and conduction band in the further part (4B). Preferably, the bandgap in the further part (4B) is made larger in that the thickness of said part (4B) is so small that quantum size effects occur therein, while the central part (4A) has a thickness which is so large that such effects do not occur or substantially do not occur.

    Optical coherence tomography
    25.
    发明申请
    Optical coherence tomography 有权
    光学相干断层扫描

    公开(公告)号:US20050232536A1

    公开(公告)日:2005-10-20

    申请号:US10523046

    申请日:2003-07-16

    摘要: An optical coherence tomography system comprises an optical source (1) has an emission wavelength in the range of 1.6(m to 2.0(m, in particular having an infrared emission predominantly at a wavelength of 1.8(m associated with a transition between an upper energy level and a lower energy level and the optical source comprises an excitation system which generates stimulated emission from a pump level to the upper energy level. Preferably, the optical source includes a Tm-doped fibre (6) in an optical cavity (1,8).

    摘要翻译: 光学相干断层摄影系统包括光源(1),其发射波长在1.6(m至2.0(m),特别是具有主要在1.8的波长的红外发射(m与上能量 优选地,光源包括在光学腔中的掺杂Tm的光纤(6)(1,8),所述激光系统将从泵浦电平产生受激发射到较高能量水平。 )。