公开(公告)号：US07731683B2

公开(公告)日：2010-06-08

申请号：US11220227

申请日：2005-09-06

申请人： Yue-Teh Jang ,  Ross S. Tsugita ,  Bruce S. Addis ,  Tracy D. Maahs ,  Jean C. Chang

发明人： Yue-Teh Jang ,  Ross S. Tsugita ,  Bruce S. Addis ,  Tracy D. Maahs ,  Jean C. Chang

IPC分类号： A61M29/00

CPC分类号： A61B17/22 ,  A61B2017/22067 ,  A61B2217/005 ,  A61B2217/007 ,  A61M25/007 ,  A61M25/1011 ,  A61M2206/16

摘要： A catheter system comprising a guidewire, an endovascular catheter, and an aspiration catheter. The guidewire has an expandable occluder mounted on a distal end. The guidewire and the endovascular catheter are insertable into a lumen of the aspiration catheter. The aspiration catheter also includes infusion and aspiration lumen(s) and port(s). Methods of using the catheter system for treating a vascular lesion and removing embolic material during the procedure are also disclosed.

摘要翻译： 导管系统，其包括导丝，血管内导管和抽吸导管。 导丝具有安装在远端上的可扩张封堵器。 引导线和血管内导管可插入到吸引导管的内腔中。 抽吸导管还包括输注和抽吸腔和端口。 还公开了在手术期间使用导管系统来治疗血管病变并去除栓塞物质的方法。

公开(公告)号：US06966902B2

公开(公告)日：2005-11-22

申请号：US09467293

申请日：1999-12-17

申请人： Ross S. Tsugita ,  Tracy D. Maahs

发明人： Ross S. Tsugita ,  Tracy D. Maahs

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61F2/01 ,  A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00243 ,  A61F2/01 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61M2025/0073 ,  A61M2210/127

摘要： A cardioplegia occluder and methods of using the device during cardiac surgery are disclosed. The system typically includes a substantially rigid cannula with an occluder mounted on the distal region of the cannula that expands upon activation to occlude the aorta downstream of an infusion port which delivers cardioplegia solution to arrest the heart. Systems including cutting blades, blade guards, flanges, radiopaque markers and occluder aligners are also disclosed. In use, the distal end of the cannula is inserted through an incision into the aorta, the occluder is expanded and cardioplegia solution is infused upstream of the aorta to arrest the heart. The infusion port can alternately be used to aspirate cardioplegia or embolic debris or other unwanted material from the aorta.

摘要翻译： 公开了一种心麻痹闭塞器和在心脏手术期间使用该装置的方法。 该系统通常包括基本上刚性的插管，其具有安装在套管的远侧区域上的封堵器，其在活化时膨胀以阻塞输送端口下游的主动脉，所述输液口输送心麻痹液以阻止心脏。 还公开了包括切割刀片，刀片护罩，法兰，不透射线标记和封堵器对准器的系统。 在使用中，套管的远端通过切口插入主动脉，闭塞器扩张，心脏停搏液溶解于主动脉上游以阻止心脏。 输液口可以交替地用于从主动脉抽吸心麻痹或栓塞性碎屑或其他不需要的物质。

公开(公告)号：US06592546B1

公开(公告)日：2003-07-15

申请号：US09016714

申请日：1998-01-30

申请人： Denise Barbut ,  Jonathan D. Root ,  Giovanni Pastrone ,  Tracy D. Maahs ,  Ross S. Tsugita

发明人： Denise Barbut ,  Jonathan D. Root ,  Giovanni Pastrone ,  Tracy D. Maahs ,  Ross S. Tsugita

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00243 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2250/0003 ,  A61M2025/0073 ,  A61M2025/1052 ,  A61M2210/127

摘要： A balloon arterial cannula and methods for filtering blood. The devices generally include a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, a means to actuate the structure, and a balloon occluder which typically includes a flexible material enclosing a chamber. The methods generally include the steps of introducing a mesh into a blood vessel to capture embolic material, adjusting the mesh, if necessary, during the course of filtration, inflating the balloon occluder to occlude the vessel upstream of the mesh, and thereafter deflating the balloon occluder and removing the mesh and the captured foreign matter from the blood vessel. Additionally, visualization techniques are used to ensure effective filtration.

摘要翻译： 气囊动脉插管和血液过滤方法。 这些装置通常包括用于过滤血管内的血液的网格，特别是在诸如主动脉的动脉内，适于打开和关闭血管内的网状物的结构，致动结构的装置和气囊封堵器 通常包括围绕室的柔性材料。 所述方法通常包括以下步骤：将网状物引入血管以捕获栓塞材料，如果需要，在过滤过程中调整网孔，使球囊封堵器膨胀以封闭网孔上游的容器，然后使气囊放气 闭塞器并从血管中除去网状物和捕获的异物。 此外，可视化技术用于确保有效的过滤。

公开(公告)号：US06589264B1

公开(公告)日：2003-07-08

申请号：US09478818

申请日：2000-01-07

申请人： Denise Barbut ,  Giovanni Pastrone ,  Tracy D. Maahs ,  Ross S. Tsugita

发明人： Denise Barbut ,  Giovanni Pastrone ,  Tracy D. Maahs ,  Ross S. Tsugita

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00243 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2250/0003 ,  A61M2025/0073 ,  A61M2025/1052 ,  A61M2210/127

摘要： A balloon arterial cannula and methods for filtering blood. The devices generally include a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, a means to actuate the structure, and a balloon occluder which typically includes a flexible material enclosing a chamber. The methods generally include the steps of introducing a mesh into a blood vessel to capture embolic material, adjusting the mesh, if necessary, during the course of filtration, inflating the balloon occluder to occlude the vessel upstream of the mesh, and thereafter deflating the balloon occluder and removing the mesh and the captured foreign matter from the blood vessel. Additionally, visualization techniques are used to ensure effective filtration.

公开(公告)号：US06319268B1

公开(公告)日：2001-11-20

申请号：US09630805

申请日：2000-08-02

申请人： William M. Ambrisco ,  Richard O. Murphy ,  Timothy J. Wood ,  Roman Turovskiy ,  Tracy D. Maahs ,  Bruce S. Addis

发明人： William M. Ambrisco ,  Richard O. Murphy ,  Timothy J. Wood ,  Roman Turovskiy ,  Tracy D. Maahs ,  Bruce S. Addis

IPC分类号： A61B1700

CPC分类号： A61F2/013 ,  A61B90/06 ,  A61F2/01 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61F2230/008

摘要： A modular blood filter device and delivery system, comprising a hollow vessel insertion device with a modular filter apparatus. The insertion device, which can be an introducer, includes a distal end adapted to enter an artery, and a proximal end adapted to receive a modular filter apparatus. When the insertion device is a cannula, the modular filter apparatus is received through a side port. The modular filter apparatus includes a shaft and an adjustable filter device or a removable filter associated with the shaft. The adjustable filter includes filter mesh, an adjustable frame capable of assuming enlarged and contracted conditions and a frame sizing mechanism associated with the frame. The adjustable frame may be self-adjusting or externally adjusted to fit the vessel and to capture embolic material in the mesh. The frame may be collapsed to the contracted condition, and may be removed from the vessel or embolic debris may be removed by an aspiration tube. The modular filter cartridge may be removed from the cannula, and a new modular filter cartridge may then be received therein.

摘要翻译： 一种模块化血液过滤装置和输送系统，包括具有模块化过滤装置的中空容器插入装置。 可以是导引器的插入装置包括适于进入动脉的远端，以及适于接收模块化过滤装置的近端。 当插入装置是插管时，通过侧端口容纳模块式过滤装置。 模块化过滤装置包括轴和可调节过滤器装置或与轴相关联的可移除过滤器。 可调节过滤器包括过滤网，能够承担放大和收缩条件的可调节框架以及与框架相关联的框架上浆机构。 可调节框架可以是自调节的或外部调整的以适应容器并捕获网状物中的栓塞物质。 框架可以折叠到收缩状态，并且可以从血管中移除，或者可以通过抽吸管去除栓塞性碎屑。 可以将模块化过滤器滤芯从插管中取出，然后可以在其中接收新的模块化过滤器滤芯。

公开(公告)号：US06270513B1

公开(公告)日：2001-08-07

申请号：US09455011

申请日：1999-12-03

申请人： Ross S. Tsugita ,  Tracy D. Maahs ,  Yue-Teh Jang

发明人： Ross S. Tsugita ,  Tracy D. Maahs ,  Yue-Teh Jang

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/01 ,  A61F2/82 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2230/0093 ,  A61F2250/0003

摘要： The invention provides a nested tubing cannula which comprises outer and inner elongate tubular members, both having a proximal end, a distal end, and a lumen therebetween. The inner tubular member is sealed at its distal end and is nested substantially coaxially within the lumen of the outer tubular member, so that the gap between the inner and the outer tubular member defines a second lumen whereas the first lumen is the lumen of the inner tubular member. A tubular sleeve is disposed coaxially between the inner and outer tubular members. A balloon is mounted on a distal region of the outer tubular member and is in communication with the first lumen. The cannula further comprises a port proximal or distal the balloon occluder and is in communication with the second lumen. Methods for making the devices herein are disclosed.

摘要翻译： 本发明提供了一种嵌套管插管，其包括外部和内部细长管状构件，两者均具有近端，远端和其间的内腔。 内部管状构件在其远端处被密封并且基本同轴地嵌套在外部管状构件的内腔中，使得内部和外部管状构件之间的间隙限定第二腔，而第一腔是内部管状构件的内腔 管状构件。 管状套筒同轴地设置在内管状构件和外管状构件之间。 气球安装在外部管状构件的远侧区域上并与第一腔连通。 套管还包括近端或远端的气囊封堵器并且与第二内腔连通的端口。 公开了制造这些装置的方法。

公开(公告)号：US6027520A

公开(公告)日：2000-02-22

申请号：US287217

申请日：1999-04-05

申请人： Ross S. Tsugita ,  Tracy D. Maahs ,  Yue-Teh Jang

发明人： Ross S. Tsugita ,  Tracy D. Maahs ,  Yue-Teh Jang

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61F2/01 ,  A61F2/02 ,  A61F2/95 ,  A61M29/00

CPC分类号： A61F2/013 ,  A61F2/01 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/82 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2230/0093 ,  A61F2250/0003

摘要： An apparatus and method for treating stenosed blood vessels is provided, more particularly a percutaneous catheter, including a filter for capturing loose embolic material, used to deliver a stent, preferably within the ascending aorta, the aortic arch, or the carotid arteries. The catheter includes an expandable stent deployed on an inflatable balloon, or alternatively a self-expanding stent. A filter assembly is provided either directly on the catheter, or in a separate sheath or on a guidewire. The filter assembly comprises an expansion frame, having filter mesh attached to it, disposed on a guidewire inserted through the catheter or sheath, or alternatively attached directly on a distal region of the catheter. The expansion frame comprises a structure which is activated from a contracted condition into an enlarged condition in a blood vessel, thereby traversing the vessel with the filter mesh. The expansion frame includes biased struts, a mechanically operated frame, and/or a fluid-operated frame. The catheter is percutaneously introduced into a blood vessel and directed to a target region. The stent is localized across the region, the filter assembly is opened, and the stent is deployed, substantially permanently engaging the walls of the blood vessel, thereby opening the stenosed region and/or containing aortic plaque.

摘要翻译： 提供一种用于治疗狭窄血管的装置和方法，更具体地说，一种经皮导管，包括用于捕获松散栓塞材料的过滤器，用于输送支架，优选在升主动脉，主动脉弓或颈动脉内。 导管包括展开在可膨胀气囊上的可扩张支架，或者替代地自扩张支架。 过滤器组件直接设置在导管上，或者设置在单独的护套中或导丝上。 过滤器组件包括具有连接到其上的过滤网的膨胀框架，其布置在插入穿过导管或护套的导丝上，或者可选地直接附接在导管的远侧区域上。 膨胀框架包括从收缩条件激活到血管中的放大状态的结构，从而穿过具有过滤网的容器。 膨胀框架包括偏置的支柱，机械操作的框架和/或流体操作的框架。 将导管经皮引入血管并引导至目标区域。 支架局部跨越该区域，过滤器组件被打开，支架被展开，基本上永久地接合血管的壁，从而打开狭窄的区域和/或包含主动脉斑块。

公开(公告)号：US6007557A

公开(公告)日：1999-12-28

申请号：US70660

申请日：1998-04-29

申请人： William M. Ambrisco ,  Richard O. Murphy ,  Timothy J. Wood ,  Roman Turovskiy ,  Tracy D. Maahs ,  Bruce S. Addis

发明人： William M. Ambrisco ,  Richard O. Murphy ,  Timothy J. Wood ,  Roman Turovskiy ,  Tracy D. Maahs ,  Bruce S. Addis

IPC分类号： A61B17/00 ,  A61B19/00 ,  A61F2/01

CPC分类号： A61F2/013 ,  A61B90/06 ,  A61F2/01 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61F2230/008

摘要： A modular blood filter device and delivery system, comprising a hollow vessel insertion device with a modular filter apparatus. The insertion device, which can be an introducer, includes a distal end adapted to enter an artery, and a proximal end adapted to receive a modular filter apparatus. When the insertion device is a cannula, the modular filter apparatus is received through a side port. The modular filter apparatus includes a shaft and an adjustable filter device or a removable filter associated with the shaft. The adjustable filter includes filter mesh, an adjustable flame capable of assuming enlarged and contracted conditions and a frame sizing mechanism associated with the frame. Certain embodiments include a filter cartridge, and the shaft is inserted into the cartridge, thereby protecting the adjustable filter device therein. The cartridge may then be removably received by the insertion device. An expandable obturator may be used to ease the entry of the insertion device into the vessel. Indexing and locking mechanisms are described for aligning the cartridge or the obturator to the insertion device. Vessel sizing tools are also described for determining the size of the vessel into which the filter will be introduced. The insertion device may then be introduced into a blood vessel, and the adjustable filter device may be deployed through the device into the vessel The adjustable frame may be self-adjusting or externally adjusted to fit the vessel and to capture embolic material in the mesh. The frame may be collapsed to the contracted condition, and may be removed from the vessel or embolic debris may be removed by an aspiration tube. The modular filter cartridge may be removed from the cannula, and a new modular filter cartridge may then be received therein.

摘要翻译： 一种模块化血液过滤装置和输送系统，包括具有模块化过滤装置的中空容器插入装置。 可以是导引器的插入装置包括适于进入动脉的远端，以及适于接收模块化过滤装置的近端。 当插入装置是插管时，通过侧端口容纳模块式过滤装置。 模块化过滤装置包括轴和可调节过滤器装置或与轴相关联的可移除过滤器。 可调节过滤器包括过滤网，可调节的火焰，能够承担放大和收缩的条件以及与框架相关联的框架上浆机构。 某些实施例包括一个过滤器滤芯，并且该轴被插入到该盒中，从而保护其中的可调节过滤装置。 然后，盒可以被插入装置可拆卸地接收。 可以使用可膨胀闭孔器来容易地将插入装置进入容器。 描述了分度和锁定机构，用于将盒或封闭器对准插入装置。 还描述了用于确定将引入过滤器的容器尺寸的容器尺寸调整工具。 然后可以将插入装置引入血管，并且可调节过滤器装置可以通过装置部署到容器中。可调框架可以是自调节的或外部调节的以适应容器并捕获网中的栓塞材料。 框架可以折叠到收缩状态，并且可以从血管中移除，或者可以通过抽吸管去除栓塞性碎屑。 可以将模块化过滤器滤芯从插管中取出，然后可以在其中接收新的模块化过滤器滤芯。

公开(公告)号：US5928192A

公开(公告)日：1999-07-27

申请号：US899606

申请日：1997-07-24

申请人： Tracy D. Maahs

发明人： Tracy D. Maahs

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61F2/958 ,  A61M29/00

CPC分类号： A61B17/12036 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61M25/1011

摘要： A balloon occlusion device for aspirating embolic material from a blood vessel, such as from the aorta during cardiac surgery. The device includes an arterial cannula having a proximal end adapted to receive blood from a bypass-oxygenator machine, a distal end adapted to enter an artery, and a blood flow lumen extending between the proximal end and an outlet on the distal end. The cannula has an aspiration port proximate to the outlet, which communicates with an aspiration lumen. The cannula also includes an inflatable balloon attached to the cannula between the outlet and the aspiration port and capable of assuming an inflated condition for occluding a blood vessel. To use the device, the distal end of the cannula is introduced into a blood vessel, such as the aorta, the outlet is oriented downstream for delivering blood, and the balloon is inflated to occlude the vessel. Fluid may then be flushed into and aspirated out through the aspiration port as desired to remove loose embolic material from the vessel upstream of the balloon. Optionally, the device may include a second deployable balloon for further occluding the vessel at a second location.

摘要翻译： 一种气球闭塞装置，用于从心脏手术中从主动脉抽吸血管中的栓塞物。 该装置包括动脉插管，其具有适于接收来自旁路 - 充氧器机器的血液的近端，适于进入动脉的远端以及在远端的近端和出口之间延伸的血流腔。 插管具有靠近出口的抽吸端口，其与抽吸腔连通。 插管还包括一个可膨胀的球囊，其附连到出口和抽吸端口之间的插管，并且能够假设用于封闭血管的膨胀状态。 为了使用该装置，将套管的远端引入诸如主动脉的血管中，将出口定向到下游以输送血液，并且使气囊膨胀以封闭血管。 然后可以根据需要将流体冲洗并通过抽吸口吸出，以从气囊上游的容器中除去松散的栓塞材料。 可选地，装置可以包括第二可展开球囊，用于在第二位置进一步闭塞血管。

公开(公告)号：US08840636B2

公开(公告)日：2014-09-23

申请号：US13245679

申请日：2011-09-26

申请人： Denise Barbut ,  Tracy D. Maahs

发明人： Denise Barbut ,  Tracy D. Maahs

IPC分类号： A61M29/00 ,  A61F2/01

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0003 ,  A61M2210/127

摘要： Devices and methods for filtering blood. The devices generally comprise a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, and a device or method to actuate the structure. The methods generally include the steps of introducing a mesh into a blood vessel to entrap emboli material, and removing the mesh and the entrapped foreign matter from the blood vessel.

摘要翻译： 用于过滤血液的装置和方法 装置通常包括用于过滤在血管内流动的血液的网，特别是在诸如主动脉的动脉内，适于打开和关闭血管内的网状物的结构，以及用于致动结构的装置或方法。 所述方法通常包括将网状物引入血管以捕获栓塞材料并从血管中除去网状物和被捕获的异物的步骤。