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21.发明授权Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke 有权用于感染和治疗急性心肌梗死和治疗中风的植入式反应系统公开(公告)号：US06468263B1
公开(公告)日：2002-10-22
申请号：US09860693
申请日：2001-05-21
IPC分类号： A61K922
CPC分类号： A61B5/0452 , A61B5/0031 , A61N1/362
摘要： Disclosed is a completely implantable system that can detect the occurrence of a myocardial infarction, i.e., a heart attack, and automatically inject a thrombolytic and/or anti-thrombogenic agent into the bloodstream to promptly dissolve the thrombus that caused the myocardial infarction and prevent the formation of additional thrombi. It is well known that a myocardial infarction can be detected from a patient's electrocardiogram by noting an ST segment voltage deviation. Upon detection of a myocardial infarction, an ST segment deviation electronic detection circuit within the implanted device can produce an output signal that can cause a thrombolytic and/or anti-thrombogenic agent contained within an implanted, pressurized reservoir to immediately and automatically release medications into the patient's bloodstream. A patient warning system is also provided by an audio alarm or an electrical tickle within the human body indicating that a myocardial infarction has been detected. An externally located part of the system, in the form of a patient operated initiator, can be used to trigger the release of medication as soon as a first sign of a stroke has been detected in order to prevent damage to brain tissue that would be caused by that stroke. Thus the system can be used to prevent trissue damage from either a myocardial infarction or a stroke. The implanted system can also send a radio message to an externally located receiver that automatically dials an emergency rescue team to take the patient to a hospital for continuing treatment of a myocardial infarction or a stroke.
摘要翻译： 公开了一种完全可植入的系统，其可以检测心肌梗死的发生，即心脏病发作，并自动将血栓溶解和/或抗血栓形成剂注射到血流中，以迅速溶解引起心肌梗死的血栓，并防止 形成额外的血栓。 众所周知，通过注意到ST段电压偏差，可以从患者的心电图中检测出心肌梗死。 在检测到心肌梗塞时，植入装置内的ST段偏移电子检测电路可以产生输出信号，其可以引起包含在植入的加压贮存器内的血栓溶解和/或抗血栓形成剂立即并自动将药物释放到 病人的血液。 患者预警系统还由人体内的音频警报器或电子痒痒声提供，表明已经检测到心肌梗死。 只要已经检测出中风的第一个迹象，为了防止会导致的脑组织的损伤，可以使用以病人操作的引发剂的形式的系统的外部定位部分，以触发药物的释放 中风。 因此，该系统可用于防止心肌梗塞或中风的三体损伤。 植入的系统还可以向外部定位的接收器发送无线电消息，自动拨打紧急救援队以将病人带到医院继续治疗心肌梗死或中风。
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22.发明授权Implantable electronic system with acute myocardial infarction detection and patient warning capabilities 有权具有急性心肌梗死检测和患者警戒能力的植入式电子系统公开(公告)号：US06272379B1
公开(公告)日：2001-08-07
申请号：US09271219
申请日：1999-03-17
IPC分类号： A61N139
CPC分类号： A61B5/0031 , A61B5/0006 , A61N1/3925
摘要： Disclosed is a system for detecting a myocardial infarction (i.e., a heart attack) at the earliest possible time and promptly warning the patient that he should immediately seek medical care. Specifically, a first embodiment of the present invention has an implantable electronic system that can sense a change in the patient's electrogram that is indicative of a myocardial infarction. If a myocardial infarction is sensed, the device would then cause an implantable or externally located alarm means such as an audio sound to be actuated to warn the patient of his condition. The patient could then promptly seek medical care, for example, at a hospital emergency room. Having been trained to recognize such an alarm, most patient would neither fail to recognize such an indication of a myocardial infarction nor would they ignore such an alarm signal if it were to occur. Since an implantable heart pacemaker or defibrillator already has within its structure many of the elements required for the device to recognize a myocardial infarction, it would be expeditious to add a capability to these existing devices to detect a myocardial infarction and provide an implantable or external alarm means to inform the patient to take appropriate action.
摘要翻译： 公开了一种用于早期检测心肌梗死（即心脏病发作）的系统，并且及时警告患者应立即求医。 具体地，本发明的第一实施例具有可以感测指示心肌梗塞的患者电描记图变化的可植入电子系统。 如果感测到心肌梗塞，则该装置然后将引起可植入或外部定位的报警装置，例如音频声音被致动以警告患者他的状况。 患者可以立即就医，例如在医院急诊室就医。 经过训练以识别这样的警报，大多数患者既不会认识到这种心肌梗塞的指示，也不会忽视这种报警信号，如果发生。 由于植入式心脏起搏器或除颤器在其结构内已经具有设备识别心肌梗塞所需要的许多元件，因此将快速地向这些现有装置添加能力以检测心肌梗死并提供可植入或外部警报 意味着通知患者采取适当的行动。
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公开(公告)号：US06221043B1
公开(公告)日：2001-04-24
申请号：US09373552
申请日：1999-08-13
IPC分类号： A61M2900
CPC分类号： A61M25/1002
摘要： Disclosed is a balloon on a distal portion of a balloon angioplasty catheter. The section of the balloon onto which a stent can be mounted has a central segment that is substantially cylindrical in shape that is centered between two segments each having the shape of a sector of a prolate spheroid. This shape for a balloon for a stent delivery catheter provides a more cylindrical shape for the stent after it is implanted in an artery that has a typical distribution of plaque in an arterial stenosis, which distribution of plaque is greatest for some limited length at a central region of the stenosis and then decreases somewhat uniformly as one approaches the edges of the stenosis. Another embodiment of the invention utilizes two segments that are frustums of a cone instead of sectors of a prolate spheroid, which conical segments surround the central cylindrical segment. Also disclosed is a balloon whose compliance decreases continuously as a function of the distance away from either end of the central segment. Any of these embodiments can employ dual conical end segments at each end of the balloon which consist of two adjacent frustums of a cone making different half-angles with the longitudinal axis of the balloon.
摘要翻译： 公开了一种在球囊血管成形术导管的远端部分上的气囊。 可以安装支架的气囊部分具有基本圆柱形的中心段，该中心段的形状中心在两个段之间，每段具有扁平球状体的扇形。 用于支架输送导管的球囊的这种形状在支架植入植入动脉狭窄的典型分布的动脉中之后为支架提供更圆柱形的形状，其中斑块的分布在中心的一些有限的长度处是最大的 狭窄区域然后随着接近狭窄边缘而稍微均匀地减小。 本发明的另一个实施例利用作为锥体的平截头体的两个部分，而不是长椭球形的扇形部分，该锥形部分围绕中心圆柱形部分。 还公开了一种球囊，其气囊的顺从性随距离中心段的任一端的距离而连续减小。 这些实施例中的任何一个可以在球囊的每个端部处使用双锥形端部段，其由与球囊的纵向轴线形成不同半角的圆锥体的两个相邻平截头体组成。
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公开(公告)号：US6017328A
公开(公告)日：2000-01-25
申请号：US695596
申请日：1996-08-12
CPC分类号： A61M5/3202 , A61M25/0606 , A61M5/158 , A61M2005/1581 , A61M2005/1585 , A61M2005/1587 , A61M5/001
摘要： The present invention is an injection port assembly for subcutaneous delivery of medication. A single molded body has a soft cannula extending downward from a generally flat bottom surface and a self-sealing septum mounted at the center of a top surface which is generally of a concave shape sloping downward towards its outer perimeter at which point the single body is very thin. The single body also has a tubular extension which is directed outward parallel to the skin's surface. A metal needle which penetrates through the septum and through the lumen of the soft cannula is used for inserting the cannula through the skin. Once the soft cannula is placed subcutaneously, the needle is removed and an adhesive tape is placed over the single body and onto the skin beyond the body's outer perimeter. By having a distal section of the needle which is smaller in diameter as compared to most of the needle's length, and by having the soft cannula fit tightly onto the needle, most of the cannula's length will be in tension during insertion thereby preventing an accordion-like compressional failure of the cannula. A quick-release connector on the proximal end of the tubular extension or mounted directly on the injection port assembly allows the tubing connecting the injection port assembly to a portable medication pump to be disconnected when the patient showers or performs some similar activity.
摘要翻译： 本发明是用于皮下递送药物的注射口组件。 单个成型体具有从大致平坦的底部表面向下延伸的软套管和安装在顶表面的中心处的自密封隔膜，该顶部表面通常具有朝向其外周向下倾斜的凹形，在该点处，单体为 很瘦。 单体还具有向外平行于皮肤表面指向的管状延伸部。 穿过隔膜并通过软套管的内腔的金属针用于插入套管穿过皮肤。 一旦软套管皮下放置，取下针头，并将胶带放置在单个身体上方并超过身体外周的皮肤上。 通过使针的远端部分与针的大部分长度相比直径较小，并且通过使软管紧紧地配合到针上，插管的大部分长度将在插入期间处于张力状态，从而防止手风琴 - 像套管的压缩失败。 管状延伸部的近端上的快速释放连接器或直接安装在注射口组件上的快速连接器允许当患者淋浴或执行某些类似的活动时将连接注射口组件的便携式药物泵断开连接。
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公开(公告)号：US08038624B2
公开(公告)日：2011-10-18
申请号：US10642245
申请日：2003-08-18
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson
IPC分类号： A61B5/0452
CPC分类号： A61B5/02455 , A61B5/0031 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/746 , A61B5/7465 , A61B2560/0209
摘要： Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.
摘要翻译： 公开了一种用于检测心脏事件（监护系统）的系统，其包括称为心脏切除器的植入装置，医师编程器和外部警报系统。 该系统旨在提供心脏事件的早期检测，例如由心率增加或运动引起的急性心肌梗死或运动诱发的心肌缺血。 如果检测到心律失常，该系统还可以警告患者不太紧急的警报。 使用一个或多个检测算法，心脏扫描器可以检测患者的电描记图中的变化，其指示在发生后五分钟内的心脏事件，然后自动向患者发出事件发生。 为了提供此警告，监护系统包括在心脏保护器内和/或外部报警系统（外部报警装置）内的内部报警子系统（内部报警装置）。 如果将监护人系统放入心脏起搏器，该算法可以根据起搏器是否实际起搏心脏，对电图进行不同的分析。
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公开(公告)号：US20110137194A1
公开(公告)日：2011-06-09
申请号：US13025476
申请日：2011-02-11
IPC分类号： A61B5/0456
CPC分类号： A61B5/02455 , A61B5/0031 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/746 , A61B5/7465 , A61B2560/0209
摘要： Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.
摘要翻译： 公开了一种用于检测心脏事件（监护系统）的系统，其包括称为心脏切除器的植入装置，医师编程器和外部警报系统。 该系统旨在提供心脏事件的早期检测，例如由心率增加或运动引起的急性心肌梗死或运动诱发的心肌缺血。 如果检测到心律失常，该系统还可以警告患者不太紧急的警报。 使用一个或多个检测算法，心脏扫描器可以检测患者的电描记图中的变化，其指示在发生后五分钟内的心脏事件，然后自动向患者发出事件发生。 为了提供此警告，监护系统包括在心脏保护器内和/或外部报警系统（外部报警装置）内的内部报警子系统（内部报警装置）。 如果将监护人系统放入心脏起搏器，该算法可以根据起搏器是否实际起搏心脏，对电图进行不同的分析。
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公开(公告)号：US07037327B2
公开(公告)日：2006-05-02
申请号：US09961927
申请日：2001-09-24
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/90 , A61F2002/9583 , A61F2250/0018 , A61F2250/0042 , A61F2250/0048
摘要： A hybrid stent that is defined as having a central section that is balloon expandable and end sections that are self-expanding. The entire stent is mounted on a balloon of a balloon angioplasty catheter. One way to retain the self-expanding portion of the stent onto a balloon onto which it has been nested is to place a cylindrical elastomer tube around each of the self-expanding end sections of the stent. Another way to retain the hybrid stent onto a stent delivery system is to use a conventional sheath that is pulled back to initiate stent deployment
摘要翻译： 被定义为具有球囊可膨胀的中心部分和自膨胀的末端部分的混合支架。 整个支架安装在球囊血管成形术导管的球囊上。 将支架的自膨胀部分保持在其已经嵌套在其上的气球上的一种方法是将圆柱形弹性体管围绕在支架的每个自扩张端部分上。 将混合支架保持在支架输送系统上的另一种方法是使用被拉回以启动支架部署的常规护套
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公开(公告)号：US07011673B2
公开(公告)日：2006-03-14
申请号：US10107221
申请日：2002-03-26
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/958 , A61M2025/0186 , A61M2025/1004
摘要： The present invention is a stent delivery system that uses a short section of a guide wire that is fixedly attached to a distal section of a balloon angioplasty catheter. By not having a guide wire that slides through the balloon of the balloon angioplasty catheter, the balloon on which the stent is mounted can have a reduced diameter. Therefore, the outside diameter of the undeployed stent mounted onto that balloon is also minimized. This provides a minimum profile, i.e., a minimum outside diameter, for the stent. A minimum profile at the distal section of the stent delivery system is highly advantageous for improving the percentage of cases that can be treated by means of direct stenting; i.e., without requiring pre-dilation of a stenosis.
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公开(公告)号：US06547817B1
公开(公告)日：2003-04-15
申请号：US09596074
申请日：2000-06-16
IPC分类号： A61M2900
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： An expandable stent for delivery to a coronary artery. The stent has at least two longitudinally spaced apart circumferential rings having closed ends. Each of the circumferential rings has at least two peak segments and at least two valley segments. At least one longitudinally extending connector extends between adjacent circumferential rings. The connector has a first end portion fixedly connected to a first circumferential ring and a second end portion fixedly connected to an adjacent circumferential ring. The connector has at least one circumferentially extending turn back portion between its first and second end portions that can expand or contract in length while being passed through a curved coronary artery.
摘要翻译： 用于输送到冠状动脉的可扩张支架。 支架具有至少两个具有闭合端的纵向间隔开的周向环。 每个周向环具有至少两个峰段和至少两个谷段。 至少一个纵向延伸的连接件在相邻周向环之间延伸。 连接器具有固定地连接到第一周向环的第一端部和固定地连接到相邻周向环的第二端部。 连接器在其第一和第二端部之间具有至少一个沿圆周方向延伸的折回部分，其能够在穿过弯曲的冠状动脉的同时膨胀或收缩。
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公开(公告)号：US06315708B1
公开(公告)日：2001-11-13
申请号：US09540629
申请日：2000-03-31
IPC分类号： A61N500
CPC分类号： A61F2/958 , A61F2/90 , A61F2002/9583 , A61F2250/0018 , A61F2250/0042 , A61F2250/0048
摘要： The present invention is a hybrid stent that is defined as having a central section that is balloon expandable and end sections that are self-expanding. The entire stent is mounted on a balloon of a balloon angioplasty catheter. One way to retain the self-expanding portion of the stent onto a balloon onto which it has been nested is to place a cylindrical elastomer tube around each of the self-expanding end sections of the stent. Another way to retain the hybrid stent onto a stent delivery system is to use a conventional sheath that is pulled back to initiate stent deployment
摘要翻译： 本发明是一种混合型支架，其被定义为具有球囊可膨胀的中心部分和自膨胀的端部。 整个支架安装在球囊血管成形术导管的球囊上。 将支架的自膨胀部分保持在其已经嵌套在其上的气球上的一种方法是将圆柱形弹性体管围绕在支架的每个自扩张端部分上。 将混合支架保持在支架输送系统上的另一种方法是使用被拉回以启动支架部署的常规护套
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