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    Intravascular fluid catheter with minimal internal fluid volume
    1.
    发明授权
    Intravascular fluid catheter with minimal internal fluid volume 有权

    公开(公告)号：US10576246B2

    公开(公告)日：2020-03-03

    申请号：US13643065

    申请日：2012-08-22

    申请人： David R. Fischell ,  Tim A. Fischell

    发明人： David R. Fischell ,  Tim A. Fischell

    IPC分类号： A61M25/00 ,  A61M25/06 ,  A61M25/01 ,  A61B5/00

    摘要： A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery.

    Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
    2.
    发明授权
    Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation 有权
    用于血管壁注射和肌肉和神经纤维消融的可扩展导管系统

    公开(公告)号：US09278196B2

    公开(公告)日：2016-03-08

    申请号：US13216495

    申请日：2011-08-24

    申请人： David R. Fischell ,  Tim A. Fischell

    发明人： David R. Fischell ,  Tim A. Fischell

    IPC分类号： A61M25/06 ,  A61M25/00 ,  A61B5/00

    CPC分类号： A61M25/0662 ,  A61B5/6848 ,  A61M25/0084 ,  A61M25/0097 ,  A61M2025/0086 ,  A61M2025/0681

    摘要： A vascular nerve ablation (denervation) system includes a multiplicity of expandable needles which open around a central axis to engage the wall of a blood vessel allowing the injection of a cytotoxic or neurotoxic solution for ablating conducting tissue in and near the vessel wall of a renal artery or pulmonary vein. The expandable needles are formed of self-expanding materials and include structures which limit the distance of penetration of the injection needles into the tissue of the wall of the blood vessel.

    摘要翻译： 血管神经消融（去神经支配）系统包括多个可展开的针，其围绕中心轴线开放以接合血管壁，允许注射细胞毒性或神经毒性溶液以消除肾脏血管壁内和附近的传导组织 动脉或肺静脉。 可膨胀针由自膨胀材料形成，并且包括限制注射针穿入血管壁组织的距离的结构。

    Ischemia detection systems for paced-patients using beat-type dependent baseline datasets
    3.
    发明授权
    Ischemia detection systems for paced-patients using beat-type dependent baseline datasets 有权
    使用节拍型依赖基线数据集的针对患者的缺血检测系统

    公开(公告)号：US08805498B1

    公开(公告)日：2014-08-12

    申请号：US12624515

    申请日：2009-11-24

    申请人： David R. Fischell ,  Michael Sasha John ,  David Keenan

    发明人： David R. Fischell ,  Michael Sasha John ,  David Keenan

    IPC分类号： A61N1/362

    CPC分类号： A61N1/37247 ,  A61N1/056 ,  A61N1/36592

    摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to distinguish between two different heart beats types such as ventricularly paced beats and supraventricular beats. The processor collects separate reference data for each beat type indicative of the normal values of a cardiac feature associated with these beat types. The processor performs an ischemia test by separately comparing present values of the cardiac feature for each beat type with the reference values for the corresponding beat type.

    摘要翻译： 公开了一种用于检测心脏缺血的装置。 该装置包括处理器，其被配置为区分两种不同的心跳类型，例如心室起搏节拍和室上搏动。 处理器针对指示与这些节拍类型相关联的心脏特征的正常值的每个节拍类型收集单独的参考数据。 处理器通过将每个节拍类型的心脏特征的当前值与相应节拍类型的参考值分开比较来执行缺血测试。

    Cardiac event categorization system
    6.
    发明授权
    Cardiac event categorization system 有权
    心脏事件分类系统

    公开(公告)号：US08483812B2

    公开(公告)日：2013-07-09

    申请号：US12059146

    申请日：2008-03-31

    申请人： Robert E. Fischell ,  David R. Fischell ,  Tim A. Fischell ,  Scott J. S. Fischell

    发明人： Robert E. Fischell ,  David R. Fischell ,  Tim A. Fischell ,  Scott J. S. Fischell

    IPC分类号： A61B5/02 ,  A61N1/365

    CPC分类号： A61L27/54 ,  A61L2300/236 ,  A61L2300/254 ,  A61L2300/42

    摘要： Disclosed are methods for detecting an acute myocardial infarction (i.e., a heart attack) at the earliest possible time and promptly warning the patient that he should immediately seek medical care. The present invention includes an implantable electronic system that can sense a change in the patient's electrogram that is indicative of a heart attack. If a heart attack is sensed, the device would then cause an implantable and/or externally located alarm to be actuated to warn the patient of his condition and a medical practitioner at a remote diagnostic center would receive the patient's electrogram for analysis. The patient or a caretaker would then be informed to self-inject medication through a subcutaneous, pass-through drug port that can be a separate device or integrated into the implanted device that is designed for the early detection of a heart attack. The methods of the present invention include determining if a human patient is likely to have a heart attack and, if he is, then implanting within that patient a device that can sense when a heart attack occurs and alarm the patient to take appropriate actions if a heart attack does occur.

    摘要翻译： 公开了在早期检测急性心肌梗塞（即心脏病发作）的方法，并且及时警告患者他应该立即求医。 本发明包括可以感测指示心脏病发作的患者电描记图变化的可植入电子系统。 如果感测到心脏病发作，则该装置然后将致动可植入和/或外部定位的警报器，以警告患者其状况，并且远程诊断中心的医务人员将接收患者的电描记图以进行分析。 然后将患者或看守者通知皮下，通过的药物口，自动注射药物，该药物口可以是单独的装置，也可以集成到设计用于早期发现心脏病发作的植入装置中。 本发明的方法包括确定人类患者是否可能患有心脏病发作，并且如果他是，则在患者体内植入可以感测发生心脏病发作的装置，并且如果 心脏病发作确实发生。

    EXPANDABLE CATHETER SYSTEM FOR VESSEL WALL INJECTION AND MUSCLE AND NERVE FIBER ABLATION
    7.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR VESSEL WALL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权
    用于船舶注射和肌肉和神经纤维的膨胀导管系统

    公开(公告)号：US20130053821A1

    公开(公告)日：2013-02-28

    申请号：US13216495

    申请日：2011-08-24

    申请人： DAVID R. FISCHELL ,  TIM A. FISCHELL

    发明人： DAVID R. FISCHELL ,  TIM A. FISCHELL

    IPC分类号： A61M25/10

    CPC分类号： A61M25/0662 ,  A61B5/6848 ,  A61M25/0084 ,  A61M25/0097 ,  A61M2025/0086 ,  A61M2025/0681

    摘要： A vascular nerve ablation (denervation) system includes a multiplicity of expandable needles which open around a central axis to engage the wall of a blood vessel allowing the injection of a cytotoxic or neurotoxic solution for ablating conducting tissue in and near the vessel wall of a renal artery or pulmonary vein. The expandable needles are formed of self-expanding materials and include structures which limit the distance of penetration of the injection needles into the tissue of the wall of the blood vessel.

    摘要翻译： 血管神经消融（去神经支配）系统包括多个可展开的针，其围绕中心轴线开放以接合血管壁，允许注射细胞毒性或神经毒性溶液以消除肾脏血管壁内和附近的传导组织 动脉或肺静脉。 可膨胀针由自膨胀材料形成，并且包括限制注射针穿入血管壁组织的距离的结构。

    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION
    8.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权
    膀胱注射和肌肉和神经纤维的放大导管系统

    公开(公告)号：US20120271301A1

    公开(公告)日：2012-10-25

    申请号：US13092363

    申请日：2011-04-22

    申请人： DAVID R. FISCHELL ,  TIM A. FISCHELL

    发明人： DAVID R. FISCHELL ,  TIM A. FISCHELL

    IPC分类号： A61B18/12

    CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/143 ,  A61M5/00

    摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.

    摘要翻译： 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针头进入左心房壁的距离的成员。 本发明还可用于消除肾动脉口周围的组织用于治疗高血压。

    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION
    9.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权
    膀胱注射和肌肉和神经纤维的放大导管系统

    公开(公告)号：US20120271277A1

    公开(公告)日：2012-10-25

    申请号：US13196104

    申请日：2011-08-02

    申请人： DAVID R. FISCHELL ,  TIM A. FISCHELL

    发明人： DAVID R. FISCHELL ,  TIM A. FISCHELL

    IPC分类号： A61M29/00

    CPC分类号： A61B18/06 ,  A61B5/042 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/22038 ,  A61B2017/22068 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00285 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2090/3966 ,  A61M2025/0087

    摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

    摘要翻译： 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针穿入左心房壁或主动脉壁的距离的构件。 本发明还具有重要的应用，用于消除一个或两个肾动脉周围的组织，用于消除去往或来自每个肾脏的交感神经纤维和/或其他传入或传出神经以治疗高血压。