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公开(公告)号：US20130197021A1
公开(公告)日：2013-08-01
申请号：US13697232
申请日：2011-05-10
IPC分类号： A61K9/00 , A61K31/485
CPC分类号： A61K9/0002 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2095 , A61K31/485
摘要： The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human being
摘要翻译： 本发明涉及延长释放的药物剂型，其制备方法及其用于给予人的用途
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公开(公告)号：US20060165790A1
公开(公告)日：2006-07-27
申请号：US11314464
申请日：2005-12-20
申请人： Malcolm Walden , Geoffrey Hayes , Hassan Mohammad , Harjit Tamber , Steve Whitelock , Vincenzo Martinelli
发明人： Malcolm Walden , Geoffrey Hayes , Hassan Mohammad , Harjit Tamber , Steve Whitelock , Vincenzo Martinelli
IPC分类号： A61K31/485 , A61K9/22
CPC分类号： A61K9/1635 , A61K9/4808 , A61K31/485
摘要： Multipartulates of oxycodone can be made by extrusion of a blend which suitably contains (a) oxycodone, (b) water-insoluble ammonium methacrylate copolymer, (c) plasticiser, (d) lubricant and (e) water permeability modifier.
摘要翻译： 羟考酮的多部分可以通过挤出适合含有（a）羟考酮，（b）水不溶性甲基丙烯酸铵共聚物，（c）增塑剂，（d）润滑剂和（e）水渗透性改性剂）的共混物来制备。
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23.发明申请Gastroretentive drug delivery system comprising an extruded hydratable polymer 审中-公开包含挤出的可水合聚合物的胃肠药物递送系统公开(公告)号：US20050249798A1
公开(公告)日：2005-11-10
申请号：US10517858
申请日：2003-06-18
申请人： Hassan Mohammad
发明人： Hassan Mohammad
CPC分类号： A61K9/4808 , A61K9/0065
摘要： According to the present invention there is provided a pharmaceutical product for retention in the stomach. The product is produced by extrusion. The use of extrusion enables the product to take many useful forms. The product may comprise a sheet of hydratable polymer, the hydrated sheet being of a size which will not pass out of the stomach, for example a shaped sheet or a roll. The product may also comprise a sealed hollow tubular extrudate, for example a tube sealed at both ends. The product may comprise a filled capsule.
摘要翻译： 根据本发明，提供了用于保留在胃中的药物产品。 该产品通过挤压生产。 使用挤出使产品能够采取许多有用的形式。 该产品可以包含一层可水合聚合物，该水合片的尺寸不会超过胃，例如成形片或卷。 产品还可以包括密封的中空管状挤出物，例如在两端密封的管。 产品可以包括填充的胶囊。
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公开(公告)号：US09901540B2
公开(公告)日：2018-02-27
申请号：US13697232
申请日：2011-05-10
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K31/485
CPC分类号： A61K9/0002 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2095 , A61K31/485
摘要： The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human being.
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公开(公告)号：US09700508B2
公开(公告)日：2017-07-11
申请号：US13697197
申请日：2011-05-10
申请人： Helen Kathleen Danagher , Hassan Mohammad , Malcolm Walden , Geoffrey Gerard Hayes , Jonathon Oliver Whitehouse , Thinnayam Naganathan Krishnamurthy , Ricardo Alberto Vargas Rincon
发明人： Helen Kathleen Danagher , Hassan Mohammad , Malcolm Walden , Geoffrey Gerard Hayes , Jonathon Oliver Whitehouse , Thinnayam Naganathan Krishnamurthy , Ricardo Alberto Vargas Rincon
CPC分类号： A61K9/0002 , A61K9/1635 , A61K9/1652 , A61K9/1676 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2866 , A61K9/5078 , A61K31/485 , A61K2300/00
摘要： The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.
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公开(公告)号：US20130178492A1
公开(公告)日：2013-07-11
申请号：US13697197
申请日：2011-05-10
申请人： Helen Kathleen Danagher , Hassan Mohammad , Malcolm Walden , Geoffrey Gerard Hayes , Jonathon Oliver Whitehouse , Thinnayam Naganathan Krishnamurthy , Ricardo Alberto Vargas Rincon
发明人： Helen Kathleen Danagher , Hassan Mohammad , Malcolm Walden , Geoffrey Gerard Hayes , Jonathon Oliver Whitehouse , Thinnayam Naganathan Krishnamurthy , Ricardo Alberto Vargas Rincon
IPC分类号： A61K9/00
CPC分类号： A61K9/0002 , A61K9/1635 , A61K9/1652 , A61K9/1676 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2866 , A61K9/5078 , A61K31/485 , A61K2300/00
摘要： The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.
摘要翻译： 本发明涉及延长释放的药物剂型，其制备方法及其用于给予人类的用途。
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27.发明申请IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING OXYCODONE AND NALOXONE 有权立即释放包含氧化还原酮和纳洛酮的药物组合物公开(公告)号：US20120088786A1
公开(公告)日：2012-04-12
申请号：US13255504
申请日：2010-03-10
申请人： Helen Kathleen Dadagher , Geoffrey Gerard Hayes , Gerhard Josef Heun , Hassan Mohammad , Malcolm Walden , Jonathon Oliver Whitehouse
发明人： Helen Kathleen Dadagher , Geoffrey Gerard Hayes , Gerhard Josef Heun , Hassan Mohammad , Malcolm Walden , Jonathon Oliver Whitehouse
IPC分类号： A61K31/439 , A61P29/02
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2018 , A61K9/2059 , A61K2300/00
摘要： The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.
摘要翻译： 本发明涉及适用于治疗患有疼痛的患者的口服立即释放药物组合物，其包含羟考酮和纳洛酮或其药学上可接受的盐。
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公开(公告)号：US20100047337A1
公开(公告)日：2010-02-25
申请号：US12225228
申请日：2007-03-16
申请人： Malcolm Walden , Hassan Mohammad , Geoffrey Gerard Hayes , Helen Kathleen Danagher , Jonathan Oliver Whitehouse
发明人： Malcolm Walden , Hassan Mohammad , Geoffrey Gerard Hayes , Helen Kathleen Danagher , Jonathan Oliver Whitehouse
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/5047 , A61K31/485
摘要： According to the invention glyceryl monostearate and a polymeric binder are employed as a spheronising aid in the manufacture of pharmaceutical spheroids containing no or substantially no microcrystalline cellulose. The spheroids can contain one or more therapeutically active agent which undergoes no or substantially no degradation when stored under accelerated temperature and humidity conditions. A coating may be applied to the spheroids; when present, the coating is preferably a controlled release coating.
摘要翻译： 根据本发明，单硬脂酸甘油酯和聚合物粘合剂用作制造不含或基本上不含微晶纤维素的药物球体的滚球助剂。 球体可以含有一种或多种治疗活性剂，当在加速的温度和湿度条件下储存时，其不经历或基本上不降解。 涂层可以施加到球体上; 当存在时，涂层优选为控释层。
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公开(公告)号：US20050191352A1
公开(公告)日：2005-09-01
申请号：US11056035
申请日：2005-02-11
申请人： Geoffrey Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
摘要翻译： 本发明涉及一种使用熔体挤出机制备控释药物挤出物的方法，其中熔融挤出机包括支撑孔的模头和与模头相邻的切割器，其中 挤出的混合物在压力下出现时会切割挤出的混合物，并仍然从模板的孔口熔化或软化。
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