公开(公告)号：US20200265921A1

公开(公告)日：2020-08-20

申请号：US16862324

申请日：2020-04-29

Applicant: SEQUENOM, INC.

Inventor： Chen ZHAO ,  Zeljko DZAKULA ,  Cosmin DECIU ,  Sung Kyun KIM ,  Amin R. MAZLOOM ,  Gregory HANNUM ,  Mathias EHRICH

IPC: G16B20/10 ,  C12Q1/6869 ,  C12Q1/6883

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of decision analyses. The decision analyses sometimes include segmentation analyses and/or odds ratio analyses.

公开(公告)号：US20160319335A1

公开(公告)日：2016-11-03

申请号：US15149045

申请日：2016-05-06

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Zeljiko DZAKULA ,  Mathias EHRICH ,  Sung Kyun KIM

IPC: C12Q1/68 ,  G06F19/18

CPC classification number: C12Q1/6827 ,  G06F19/18 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20160224724A1

公开(公告)日：2016-08-04

申请号：US14892782

申请日：2014-05-23

Applicant: SEQUENOM, INC.

Inventor： Chen ZHAO ,  Zeljko DZAKULA ,  Cosmin DECIU ,  Sung Kyun KIM ,  Amin R. MAZLOOM ,  Gregory HANNUM ,  Mathias EHRICH

IPC: G06F19/20

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of decision analyses. The decision analyses sometimes include segmentation analyses and/or odds ratio analyses.

Abstract translation: 本文提供了利用决策分析进行遗传变异的非侵入式评估的方法，过程和装置。 决策分析有时包括分段分析和/或优势比分析。

公开(公告)号：US20130295564A1

公开(公告)日：2013-11-07

申请号：US13791466

申请日：2013-03-08

Applicant: SEQUENOM, INC.

Inventor： Mathias EHRICH ,  Anders Olof Herman NYGREN ,  Tyler Jacob JENSEN

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6888 ,  C12Q2600/16 ,  C12Q2537/164 ,  C12Q2522/101 ,  C12Q2565/501

Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.

Abstract translation: 提供了利用在母亲和胎儿之间差异甲基化的基因组区域来分离，分离或富集胎儿核酸与母体样品的组合物和方法。 本文描述的组合物和方法特别适用于非侵入性产前诊断，包括检测染色体非整倍体。