利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

42 条记录 (耗时 0.051 秒)

    Monoclonal antibodies against CD30 lacking in fucosyl residues
    21.
    发明授权
    Monoclonal antibodies against CD30 lacking in fucosyl residues 有权
    针对CD30的单克隆抗体缺乏岩藻糖基残基

    公开(公告)号：US08207303B2

    公开(公告)日：2012-06-26

    申请号：US11918178

    申请日：2006-02-17

    申请人： Josephine M. Cardarelli ,  Amelia Nancy Black

    发明人： Josephine M. Cardarelli ,  Amelia Nancy Black

    IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  A61K39/395

    CPC分类号： C07K16/2878 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

    摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.

    摘要翻译： 本发明涉及缺乏岩藻糖基残基的抗-CD30抗体。 本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性，包括裂解不被所述抗体的岩藻糖基化形式裂解的CD30表达细胞系的能力。 本发明还提供表达缺乏岩藻糖基残基的抗-CD30抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺陷的。 还提供了使用抗体抑制CD30 +细胞如肿瘤细胞生长的方法。

    Anti-interferon alpha antibodies
    23.
    发明授权
    Anti-interferon alpha antibodies 有权
    抗干扰素α抗体

    公开(公告)号：US07741449B2

    公开(公告)日：2010-06-22

    申请号：US11009410

    申请日：2004-12-10

    申请人： Alison Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David King ,  David Passmore

    发明人： Alison Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David King ,  David Passmore

    IPC分类号： C07K16/00 ,  C07K16/24 ,  A61K39/395

    CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

    摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

    摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

    Monoclonal antibodies against CD30 lacking in fucosyl residues
    28.
    发明授权
    Monoclonal antibodies against CD30 lacking in fucosyl residues 有权
    针对CD30的单克隆抗体缺乏岩藻糖基残基

    公开(公告)号：US08491898B2

    公开(公告)日：2013-07-23

    申请号：US13462566

    申请日：2012-05-02

    申请人： Josephine M. Cardarelli ,  Amelia Nancy Black

    发明人： Josephine M. Cardarelli ,  Amelia Nancy Black

    IPC分类号： A61K39/395 ,  A61K39/44

    CPC分类号： C07K16/2878 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

    摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.

    摘要翻译： 本发明涉及缺乏岩藻糖基残基的抗-CD30抗体。 本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性，包括裂解不被所述抗体的岩藻糖基化形式裂解的CD30表达细胞系的能力。 本发明还提供表达缺乏岩藻糖基残基的抗-CD30抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺陷的。 还提供了使用抗体抑制CD30 +细胞如肿瘤细胞生长的方法。