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公开(公告)号：US20090028872A1
公开(公告)日：2009-01-29
申请号：US12065436
申请日：2006-09-26
申请人： Jonathan Alexander Terret , Li-Sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
发明人： Jonathan Alexander Terret , Li-Sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
摘要翻译： 本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。
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公开(公告)号：US08124738B2
公开(公告)日：2012-02-28
申请号：US12065436
申请日：2006-09-26
申请人： Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
发明人： Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
摘要翻译： 本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。
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公开(公告)号：US08097703B2
公开(公告)日：2012-01-17
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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4.发明申请Human Monoclonal Antibodies to Prostate Specific Membrane Antigen (PSMA) 审中-公开用于前列腺特异性膜抗原（PSMA）的人类单克隆抗体公开(公告)号：US20090297438A1
公开(公告)日：2009-12-03
申请号：US11918153
申请日：2006-02-17
IPC分类号： A61K51/10 , C07K16/28 , A61K39/395 , C07H21/00 , C12N15/63 , C12N5/00 , A01K67/027 , C07K1/107 , A61K38/20 , C12Q1/02 , A61P35/00
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/21
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
摘要翻译： 本发明提供以高亲和力特异性结合PSMA的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了治疗癌症的方法。
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公开(公告)号：US20080279868A1
公开(公告)日：2008-11-13
申请号：US12088066
申请日：2006-09-26
申请人： Sharon Elaine Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Bilal Sufi , Haichun Huang , David John King , Chin Pan , Josephine M. Cardarelli
发明人： Sharon Elaine Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Bilal Sufi , Haichun Huang , David John King , Chin Pan , Josephine M. Cardarelli
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
摘要翻译： 本公开提供了抗体 - 药物偶联物，其是有效的细胞毒素，其中药物通过接头与抗体连接。 本公开还涉及含有抗体 - 药物共轭物的组合物，以及使用它们的治疗方法。
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公开(公告)号：US20090142349A1
公开(公告)日：2009-06-04
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
IPC分类号： A61K39/395 , C07K16/18 , C12N15/13 , C12N15/85 , C12N5/10 , C12P21/08 , A61P35/00 , A61P19/02
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US08258266B2
公开(公告)日：2012-09-04
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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公开(公告)号：US20080253962A1
公开(公告)日：2008-10-16
申请号：US11664193
申请日：2005-09-19
IPC分类号： A61K51/00 , C07K16/18 , C12N15/11 , C12N5/06 , A61P43/00 , C12P21/04 , C12N15/00 , A61K39/395
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/2803 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-4 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-4, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
摘要翻译： 本发明提供以高亲和力特异性结合IRTA-4的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测IRTA-4的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US20080247944A1
公开(公告)日：2008-10-09
申请号：US11794606
申请日：2006-01-12
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/92 , C07K2319/30
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
摘要翻译： 本发明提供以高亲和力特异性结合IRTA-2的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测IRTA-2的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US08945546B2
公开(公告)日：2015-02-03
申请号：US13478786
申请日：2012-05-23
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
IPC分类号： A61K39/395 , A61K39/40 , C07K14/52 , C07K16/24 , A61K39/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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