公开(公告)号：US07875278B2

公开(公告)日：2011-01-25

申请号：US11918191

申请日：2006-02-17

申请人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

发明人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

IPC分类号： A61K39/00

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺少岩藻糖基残基的抗PSMA抗体。 与抗体的岩藻糖基化形式相比，本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性。 本发明还提供表达缺乏岩藻糖基残基的抗PSMA抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺乏的。 还提供了使用抗体抑制PSMA +细胞如肿瘤细胞生长的方法。

公开(公告)号：US20090060908A1

公开(公告)日：2009-03-05

申请号：US11918191

申请日：2006-02-17

申请人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

发明人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P31/00 ,  C12N5/06

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺少岩藻糖基残基的抗PSMA抗体。 与抗体的岩藻糖基化形式相比，本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性。 本发明还提供表达缺乏岩藻糖基残基的抗PSMA抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺乏的。 还提供了使用抗体抑制PSMA +细胞如肿瘤细胞生长的方法。

公开(公告)号：US08461308B2

公开(公告)日：2013-06-11

申请号：US12903853

申请日：2010-10-13

申请人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

发明人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

IPC分类号： C07K16/30

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺少岩藻糖基残基的抗PSMA抗体。 与抗体的岩藻糖基化形式相比，本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性。 本发明还提供表达缺乏岩藻糖基残基的抗PSMA抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺乏的。 还提供了使用抗体抑制PSMA +细胞如肿瘤细胞生长的方法。

公开(公告)号：US08258266B2

公开(公告)日：2012-09-04

申请号：US12472877

申请日：2009-05-27

申请人： Shrikant Deshpande ,  Haichun Huang ,  Mohan Srinivasan ,  Josephine M. Cardarelli ,  Changyu Wang ,  David B. Passmore ,  Vangipuram Rangan ,  Thomas E. Lane ,  Hans S. Keirstead ,  Michael T. Liu

发明人： Shrikant Deshpande ,  Haichun Huang ,  Mohan Srinivasan ,  Josephine M. Cardarelli ,  Changyu Wang ,  David B. Passmore ,  Vangipuram Rangan ,  Thomas E. Lane ,  Hans S. Keirstead ,  Michael T. Liu

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  C12N5/02 ,  C12N5/16 ,  C07K1/00

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

公开(公告)号：US08097703B2

公开(公告)日：2012-01-17

申请号：US11917750

申请日：2006-06-20

申请人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

发明人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

IPC分类号： C07K16/00 ,  C07K17/00 ,  C12P21/08 ,  C07K14/00

CPC分类号： C07K16/2803 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77 ,  Y02A50/412

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

公开(公告)号：US20090142349A1

公开(公告)日：2009-06-04

申请号：US11917750

申请日：2006-06-20

申请人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

发明人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10 ,  C12P21/08 ,  A61P35/00 ,  A61P19/02

CPC分类号： C07K16/2803 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77 ,  Y02A50/412

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

公开(公告)号：US08025882B2

公开(公告)日：2011-09-27

申请号：US12551250

申请日：2009-08-31

申请人： Alison J. Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David J. King ,  David B. Passmore

发明人： Alison J. Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David J. King ,  David B. Passmore

IPC分类号： A61K39/395

CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

公开(公告)号：US08758757B2

公开(公告)日：2014-06-24

申请号：US12972813

申请日：2010-12-20

申请人： Josephine M. Cardarelli ,  Tseng-hui Timothy Chen ,  David King ,  Christopher R. Bebbington ,  Sarah Lee Pogue ,  Francis J. Carr ,  Stephen Williams

发明人： Josephine M. Cardarelli ,  Tseng-hui Timothy Chen ,  David King ,  Christopher R. Bebbington ,  Sarah Lee Pogue ,  Francis J. Carr ,  Stephen Williams

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.

摘要翻译： 公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。

公开(公告)号：US08008449B2

公开(公告)日：2011-08-30

申请号：US11913217

申请日：2006-05-02

申请人： Alan J. Korman ,  Mohan Srinivasan ,  Changyu Wang ,  Mark J. Selby ,  Bingliana Chen ,  Josephine M. Cardarelli

发明人： Alan J. Korman ,  Mohan Srinivasan ,  Changyu Wang ,  Mark J. Selby ,  Bingliana Chen ,  Josephine M. Cardarelli

IPC分类号： C07K16/28

CPC分类号： A61K39/39558 ,  A61K39/00 ,  A61K39/3955 ,  A61K47/6849 ,  A61K51/10 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.

摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。

公开(公告)号：US20100143369A1

公开(公告)日：2010-06-10

申请号：US12704948

申请日：2010-02-12

申请人： Josephine M. Cardarelli ,  Alison Witte ,  Mohan Srinivasan

发明人： Josephine M. Cardarelli ,  Alison Witte ,  Mohan Srinivasan

IPC分类号： A61K39/395 ,  A61P37/06

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.

摘要翻译： 本发明提供了与IFNAR-1结合并且能够抑制I型干扰素的生物活性的分离的人单克隆抗体。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制I型干扰素介导的病症的方法，包括使用本发明的抗体治疗自身免疫疾病，移植排斥或移植物抗宿主病的方法。