-
公开(公告)号：US06861438B2
公开(公告)日：2005-03-01
申请号：US10345095
申请日：2003-01-14
申请人： Scott D. Larsen , Paul May , Karen Romines , Mark E. Schnute , Steven P. Tanis
发明人： Scott D. Larsen , Paul May , Karen Romines , Mark E. Schnute , Steven P. Tanis
IPC分类号： C07D213/38 , A61K31/4365 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P9/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P43/00 , C07D495/04 , A61K31/435
CPC分类号： C07D495/04
摘要： The invention provides a compound of formula I: wherein G, R2, and R3 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
摘要翻译： 本发明提供了式I化合物：其中G，R 2和R 3具有说明书中定义的任何值，或其药学上可接受的盐，以及可用于制备此类化合物的方法和中间体 或盐，以及使用这些化合物或盐治疗疱疹病毒感染的方法。
-
公开(公告)号：US06852731B2
公开(公告)日：2005-02-08
申请号：US10345061
申请日：2003-01-14
申请人： Scott D. Larsen , Paul May , Karen Romines , Mark E. Schnute , Steven P. Tanis , James A. Nieman , David John Anderson , Euibong J. Kim , Steven R. Turner
发明人： Scott D. Larsen , Paul May , Karen Romines , Mark E. Schnute , Steven P. Tanis , James A. Nieman , David John Anderson , Euibong J. Kim , Steven R. Turner
IPC分类号： A01N43/78 , A01N43/90 , A01N55/00 , A01N57/24 , A61K31/4365 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/675 , A61P9/10 , A61P31/22 , C07D231/12 , C07D233/54 , C07D277/28 , C07D495/04 , C07D519/00 , C07F7/10 , C07F9/6561 , A61K31/435
CPC分类号： C07D495/04
摘要： The invention provides a compound of formula I: wherein G, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.
摘要翻译： 本发明提供式I化合物：其中G，R 2，R 3和R 4具有说明书中定义的任何值，或其药学上可接受的盐，以及方法和中间体 可用于制备此类化合物或盐，以及使用这些化合物或盐预防或治疗疱疹病毒感染的方法。
-
公开(公告)号：US09598441B2
公开(公告)日：2017-03-21
申请号：US14239881
申请日：2012-08-30
申请人： Arun K. Rishi , Scott D. Larsen
发明人： Arun K. Rishi , Scott D. Larsen
IPC分类号： C07D513/10 , A61K31/433 , C07D513/20
CPC分类号： C07D513/10 , A61K31/433 , C07D513/20
摘要： The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating cancer using compounds of formula I.
-
24.发明申请PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开用于治疗神经损伤性疾病的PPAR-分散噻唑烷二酮和组合公开(公告)号：US20130053350A1
公开(公告)日：2013-02-28
申请号：US13515522
申请日：2010-12-15
IPC分类号： A61K31/426 , A61K31/675 , A61K31/427 , A61P25/00 , A61K31/444 , A61K31/4709 , A61P25/28 , A61K31/4439 , A61K31/522
摘要： The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing neurodegenerative disorders.
摘要翻译： 本发明涉及可用于治疗和/或预防神经变性疾病的噻唑烷二酮类似物和药物组合物。
-
25.发明申请PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES 审中-公开用于治疗糖尿病和其他代谢疾病的PPAR-分散噻唑烷二酮和组合公开(公告)号：US20120322728A1
公开(公告)日：2012-12-20
申请号：US13515549
申请日：2010-12-15
IPC分类号： A61K31/426 , A61K38/26 , A61K31/4985 , A61P3/10 , A61K31/513 , A61K31/427 , A61K31/675 , A61K31/4439 , A61K31/522
CPC分类号： A61K31/426 , A61K31/4439
摘要： The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.
摘要翻译： 本发明涉及可用于治疗和/或预防糖尿病的噻唑烷二酮类似物和药物组合物，任选地与第二种治疗组合。 此外，本发明还提供了在患者中诱导糖尿病性炎症症状缓解的方法，包括施用噻唑烷二酮类似物和GLP-1激动剂。
-
26.发明申请PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES 有权用于治疗代谢性疾病的PPAR-分散的噻唑烷二酮公开(公告)号：US20120309975A1
公开(公告)日：2012-12-06
申请号：US13515508
申请日：2010-12-15
IPC分类号： C07D277/34 , C07F9/6539 , C07F9/6571 , C07D417/12
CPC分类号： C07D277/34 , C07D417/12
摘要： The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
摘要翻译： 本发明涉及可用于治疗和/或预防代谢性疾病（例如，糖尿病或神经变性疾病（例如阿尔茨海默氏病））的噻唑烷二酮类和其它药剂的新型盐。
-
公开(公告)号：US06458788B1
公开(公告)日：2002-10-01
申请号：US09808902
申请日：2001-03-15
IPC分类号： A61K315377
CPC分类号： C07D405/06 , C07D237/28 , C07D413/06
摘要： Certain novel 4-hydroxycinnoline-3-carboxyamides. The compounds are particularly effective in the treatment or prevention of viral infections, particularly infections caused by herpes viruses including herpes simplex virus types 1 and 2, human herpes virus types 6, 7 and 8, varicello zoster virus, human cytomegalovirus or Epstein-Barr virus.
-
公开(公告)号：US08937182B2
公开(公告)日：2015-01-20
申请号：US13641917
申请日：2011-04-18
IPC分类号： C07D213/50 , C07D277/34 , C07F7/18
CPC分类号： C07D277/34 , C07D213/50 , C07D213/51 , C07F7/1896
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
-
公开(公告)号：US08895748B2
公开(公告)日：2014-11-25
申请号：US13813462
申请日：2011-08-09
申请人： Steven P. Tanis , Timothy Parker , Robert C. Gadwood , James R. Zeller , Gerald D. Artman, III , Scott D. Larsen
发明人： Steven P. Tanis , Timothy Parker , Robert C. Gadwood , James R. Zeller , Gerald D. Artman, III , Scott D. Larsen
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
摘要翻译： 本发明提供了可用于预防和/或治疗诸如糖尿病，肥胖症，高血压和炎症性疾病的代谢紊乱的PPARγ保留化合物（例如噻唑烷二酮类）的新颖方法。
-
30.发明授权Pyridino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents 失效吡哆醇取代的肟可用作抗动脉粥样硬化和抗高胆固醇血症药
公开(公告)号：US5565468A
公开(公告)日：1996-10-15
申请号：US313684
申请日：1994-09-27
IPC分类号： A61K31/415 , A61K31/435 , A61P9/10 , C07D471/04 , C07D487/04 , C07F7/08 , C07F7/10 , A61K31/44
CPC分类号： C07D471/04 , C07D487/04 , C07F7/0814
摘要： Imidazopyridino- and pyrazolopyridino- substituted oximes are disclosed having the formulas ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and a are as described in the claims. for the treatment of atherosclerosis and hypercholesterolemia.
摘要翻译： 公开了具有下式的咪唑并吡啶并 - 吡唑并吡啶并 - 取代的肟。其中R 1，R 2，R 3，R 4，R 5和a如权利要求书中所述，其中R 1，R 2，R 3，R 4，R 5和 。 用于治疗动脉粥样硬化和高胆固醇血症。
-
-
-
-
-
-
-
-
-
搜索结果
30 条记录 (耗时 0.049 秒)
