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公开(公告)号：US20130211092A1
公开(公告)日：2013-08-15
申请号：US13813462
申请日：2011-08-09
申请人： Steven P. Tanis , Timothy Parker , Robert C. Gadwood , James R. Zeller , Gerald D. Artman, III , Scott D. Larsen
发明人： Steven P. Tanis , Timothy Parker , Robert C. Gadwood , James R. Zeller , Gerald D. Artman, III , Scott D. Larsen
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
摘要翻译： 本发明提供了可用于预防和/或治疗诸如糖尿病，肥胖症，高血压和炎症性疾病的代谢性疾病的PPARGAMM备用化合物例如噻唑烷二酮的新方法。
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公开(公告)号：US08895748B2
公开(公告)日：2014-11-25
申请号：US13813462
申请日：2011-08-09
申请人： Steven P. Tanis , Timothy Parker , Robert C. Gadwood , James R. Zeller , Gerald D. Artman, III , Scott D. Larsen
发明人： Steven P. Tanis , Timothy Parker , Robert C. Gadwood , James R. Zeller , Gerald D. Artman, III , Scott D. Larsen
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
摘要翻译： 本发明提供了可用于预防和/或治疗诸如糖尿病，肥胖症，高血压和炎症性疾病的代谢紊乱的PPARγ保留化合物（例如噻唑烷二酮类）的新颖方法。
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公开(公告)号：US08933240B2
公开(公告)日：2015-01-13
申请号：US13813516
申请日：2011-08-09
IPC分类号： C07D277/34 , C07C309/65 , C07C309/66 , C07C309/73 , C07C251/48 , C07F9/145
CPC分类号： C07D277/34 , C07C251/48 , C07C309/65 , C07C309/66 , C07C309/73 , C07F9/145
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
摘要翻译： 本发明提供了可用于预防和/或治疗诸如糖尿病，肥胖症，高血压和炎性疾病的代谢性疾病的PPARγ保留化合物例如噻唑烷二酮的新颖方法。
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公开(公告)号：US20130204008A1
公开(公告)日：2013-08-08
申请号：US13813516
申请日：2011-08-09
IPC分类号： C07D277/34 , C07F9/145 , C07C251/48
CPC分类号： C07D277/34 , C07C251/48 , C07C309/65 , C07C309/66 , C07C309/73 , C07F9/145
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
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公开(公告)号：US20130211095A1
公开(公告)日：2013-08-15
申请号：US13641898
申请日：2011-04-18
IPC分类号： C07D277/04
CPC分类号： C07D213/50 , C07D277/04 , C07D277/34
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
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公开(公告)号：US08937182B2
公开(公告)日：2015-01-20
申请号：US13641917
申请日：2011-04-18
IPC分类号： C07D213/50 , C07D277/34 , C07F7/18
CPC分类号： C07D277/34 , C07D213/50 , C07D213/51 , C07F7/1896
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
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公开(公告)号：US20130204004A1
公开(公告)日：2013-08-08
申请号：US13641917
申请日：2011-04-18
IPC分类号： C07D277/34 , C07F7/18 , C07D213/50
CPC分类号： C07D277/34 , C07D213/50 , C07D213/51 , C07F7/1896
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
摘要翻译： 本发明提供了可用于预防和/或治疗诸如糖尿病，肥胖症，高血压和炎症性疾病的代谢性疾病的PPARGAMM备用化合物例如噻唑烷二酮的新方法。
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公开(公告)号：US5362883A
公开(公告)日：1994-11-08
申请号：US208771
申请日：1994-03-08
IPC分类号： C07C227/10 , C07C227/12 , C07C227/22 , C07C229/28 , C07C255/46 , C07D209/54
CPC分类号： C07C227/12 , C07C227/10 , C07C227/22 , C07C229/28 , C07C255/46 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.
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9.发明申请Preparation of Amides of Retinoic Acid Via Mixed Anhydride and Mixed Carbonate Intermediates 审中-公开通过混合酸酐和混合碳酸酯中间体制备视黄酸酰胺公开(公告)号：US20080221349A1
公开(公告)日：2008-09-11
申请号：US11968252
申请日：2008-01-02
IPC分类号： C07C69/618
CPC分类号： C07C231/02 , C07C2601/16 , C07C233/28
摘要： Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.
摘要翻译： 公开了制备视黄酸酰胺的方法。 还公开了可用于制备视黄酸酰胺的中间体。 在本发明的一个方案中，通过其相应的混合酸酐或混合碳酸酯活化视黄酸（维A酸），然后将活化的中间体与4-氨基苯酚反应，产生芬维A胺。 视黄酸的其它酰胺和视黄酸的异构体如9-顺式或13-顺式也可以通过本发明制备。
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10.发明授权Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,]pyrimidin-4-ones 失效2-氨基-3,5-二氢-7-取代-4H-吡咯并[3,2-d]嘧啶-4-酮的合成方法
公开(公告)号：US5386031A
公开(公告)日：1995-01-31
申请号：US167751
申请日：1993-12-15
IPC分类号： A61K31/505 , A61P19/06 , A61P37/00 , C07D487/04 , C07B31/00
CPC分类号： C07D487/04
摘要： An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-one is converted to a diazonium salt which is subsequently catalytically hydrogenated to the desired compound, as well as valuable intermediates used in the process.
摘要翻译： 描述了制备2-氨基-3,5-二氢-7-取代-4H-吡咯并[3,2-d]嘧啶-4-酮的改进方法，其中2,6-二氨基-3,5-二氢 -7-取代-4H-吡咯并[3,2-d]嘧啶-4-酮转化成重氮盐，其随后催化氢化成所需化合物，以及在该方法中使用的有价值的中间体。
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