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公开(公告)号：US09295845B2
公开(公告)日：2016-03-29
申请号：US11427517
申请日：2006-06-29
CPC分类号： A61N1/3627 , A61N1/37 , A61N1/371 , A61N1/3712
摘要： A method and apparatus is described for preventing or reducing the ventricular remodeling that normally occurs after a myocardial infarction using pacing therapy. By pacing sites in proximity to the infarct with appropriately timed pacing pulses, the infarct region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the stimulus for remodeling. If capture by the pacing pulses is not being achieved, the device may be configured to change the pacing pulse energy and/or pacing site as appropriate.
摘要翻译： 描述了一种用于预防或减少通常在使用起搏治疗的心肌梗塞后发生的心室重塑的方法和装置。 通过用适当的定时起搏脉冲对位于梗塞范围附近的部位进行起搏，梗塞区域以减轻其受到的机械应力的方式预激发，从而减少重塑的刺激。 如果没有实现通过起搏脉冲的捕获，则该装置可以被配置为适当地改变起搏脉冲能量和/或起搏部位。
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公开(公告)号：US20090036938A1
公开(公告)日：2009-02-05
申请号：US11830508
申请日：2007-07-30
申请人： Robert Shipley , Guy Alvarez , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Joseph Walker
发明人： Robert Shipley , Guy Alvarez , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Joseph Walker
IPC分类号： A61N1/04
CPC分类号： A61N1/36003 , A61H9/0078 , A61H2201/165 , A61H2230/06 , A61H2230/20 , A61H2230/30 , A61N1/36017 , A61N1/36114
摘要： An improved system for delivering external counterpulsation therapy is described. The system employs muscle stimulation transducers such as cutaneous electrodes in order to stimulate skeletal muscle and/or vascular smooth muscle in synchronization with the cardiac cycle in a manner that increases the fluid pressure within veins and/or arteries during cardiac diastole.
摘要翻译： 描述了用于递送外部反搏疗法的改进系统。 该系统采用肌肉刺激换能器，例如皮肤电极，以便以心脏舒张期内增加静脉和/或动脉内的流体压力的方式与心脏周期同步地刺激骨骼肌和/或血管平滑肌。
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公开(公告)号：US09265949B2
公开(公告)日：2016-02-23
申请号：US11168024
申请日：2005-06-28
CPC分类号： A61N1/3627 , A61M5/14276 , A61N1/36521 , A61N1/36585 , A61N1/3756
摘要： Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.
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24.发明授权公开(公告)号：US08731677B2
公开(公告)日：2014-05-20
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。
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公开(公告)号：US20130110189A1
公开(公告)日：2013-05-02
申请号：US13721796
申请日：2012-12-20
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3621 , A61N1/36521 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates cardiac protection pacing sequences including at least one postconditioning sequence to protect the heart from a detected ischemic event and a plurality prophylactic preconditioning sequences to protect the heart from probable future ischemic events.
摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施例中，起搏系统启动心脏保护起搏序列，包括至少一个后处理序列以保护心脏免受所检测的缺血事件和多个预防性预处理序列，以保护心脏免受可能的未来缺血事件。
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26.发明授权Method and apparatus for control of cardiac therapy using non-invasive hemodynamic sensor 有权使用非侵入性血液动力学传感器控制心脏治疗的方法和装置公开(公告)号：US08046069B2
公开(公告)日：2011-10-25
申请号：US11315032
申请日：2005-12-22
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译： 心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。 非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。 一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。
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27.发明授权Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect 有权间歇性应激增加起搏的控制输送用于心脏保护作用公开(公告)号：US08027723B2
公开(公告)日：2011-09-27
申请号：US12109169
申请日：2008-04-24
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36557 , A61N1/3684 , A61N1/3688 , A61N1/3702
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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28.发明授权Method and apparatus for controlling cardiac therapy using ultrasound transducer 有权使用超声波换能器控制心脏治疗的方法和装置公开(公告)号：US07914452B2
公开(公告)日：2011-03-29
申请号：US11539939
申请日：2006-10-10
CPC分类号： A61N1/3627 , A61N1/36528
摘要： A cardiac rhythm management (CRM) system provides for post-myocardial infarction (MI) therapy with closed-loop control using one or more ultrasound transducers sensing one or more ultrasound signals indicative of cardiac dimensions. Cardiac size parameters are produced using the one or more ultrasound signals to represent, for example, cardiac chamber diameter, cardiac chamber volume, cardiac wall thickness, infarct size, and degree of change in any of these parameters over time or between measurements. In various embodiments, such cardiac size parameters provide for titration, safety check, and acute optimization of the post-MI therapy.
摘要翻译： 心律控制（CRM）系统通过使用一个或多个超声换能器感测一个或多个指示心脏尺寸的超声信号，通过闭环控制提供心肌梗死后心肌梗死（MI）治疗。 使用一个或多个超声信号产生心脏尺寸参数，以表示例如心脏室直径，心室容积，心壁厚度，梗塞面积以及随时间或测量之间的任何这些参数的变化程度。 在各种实施方案中，这种心脏尺寸参数提供滴定，安全性检查和MI后治疗的急性优化。
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29.发明申请DYNAMIC DEVICE THERAPY CONTROL FOR TREATING POST MYOCARDIAL INFARCTION PATIENTS 有权用于治疗心肌梗死患者的动态装置治疗控制公开(公告)号：US20110054557A1
公开(公告)日：2011-03-03
申请号：US12942471
申请日：2010-11-09
申请人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
发明人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.
摘要翻译： 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行后重建控制。
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30.发明授权公开(公告)号：US07877140B2
公开(公告)日：2011-01-25
申请号：US11220023
申请日：2005-09-06
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/3684
摘要： A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an intravascular pressure measurement in order to balance the beneficial effects of stress reduction with hemodynamic compromise.
摘要翻译： 描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。 根据血管内压力测量调节预激发起搏，以平衡应力减少与血液动力学妥协的有益效果。
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