Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors
    23.
    发明申请
    Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors 审中-公开
    针对使用可溶性酪氨酸激酶受体进行癌症治疗的多种血管生成途径

    公开(公告)号:US20060234347A1

    公开(公告)日:2006-10-19

    申请号:US11401340

    申请日:2006-04-10

    摘要: Multivalent soluble receptor proteins that bind to more than one angiogenic factor are described. Nucleotide and vector sequences which encode the multivalent soluble receptor protein, as well as host cells which comprise them and methods of making and using them are also described. The multivalent soluble receptor proteins and vectors which encode them find utility in treatment of cancer and other diseases associated with angiogenesis.

    摘要翻译: 描述了结合多于一种血管生成因子的多价可溶性受体蛋白。 还描述了编码多价可溶性受体蛋白质的核苷酸和载体序列,以及包含它们的宿主细胞以及制备和使用它们的方法。 编码它们的多价可溶性受体蛋白质和载体可用于治疗与血管发生相关的癌症和其它疾病。

    Dual-ended press pin and assembly
    25.
    发明申请
    Dual-ended press pin and assembly 审中-公开
    双头压脚和组装

    公开(公告)号:US20060018709A1

    公开(公告)日:2006-01-26

    申请号:US10896457

    申请日:2004-07-22

    IPC分类号: F16D1/00

    摘要: A press pin for mounting in a panel structure comprises a central retaining portion adapted to be inserted into an opening in the panel structure, a first end pin feature protruding from a first side of the central retaining portion, and a second end pin feature protruding from a second side of the central retaining portion.

    摘要翻译: 用于安装在面板结构中的按压销包括适于插入面板结构中的开口中的中央保持部分,从中央保持部分的第一侧突出的第一端销特征,以及从第二端销特征突出的第二端销特征 中央保持部分的第二侧。

    Business card presentation via mobile phone
    26.
    发明授权
    Business card presentation via mobile phone 失效
    通过手机进行名片展示

    公开(公告)号:US06873861B2

    公开(公告)日:2005-03-29

    申请号:US09833338

    申请日:2001-04-12

    摘要: A method for providing an electronic business card to a contact via a cellular phone is disclosed. Several business card menu options are provided to a user of a cellular telephone. The cellular phone user enters business card information/data into the cellular phone utilizing the business card menu options. The business card data is stored locally on the cellular phone or in a service provider database. When the user is in communication via cellular phone with someone he wishes to provide his business card to, the user selects a menu item that activates the transmission of the electronic business card to the desired recipient's cellular phone.

    摘要翻译: 公开了一种通过蜂窝电话向联系人提供电子名片的方法。 几个名片菜单选项被提供给蜂窝电话的用户。 蜂窝电话用户使用名片菜单选项将名片信息/数据输入到蜂窝电话中。 名片数据本地存储在蜂窝电话或服务提供商数据库中。 当用户通过蜂窝电话与他希望提供他的名片的人进行通信时,用户选择激活电子名片传输到所需接收者的蜂窝电话的菜单项。

    System and method for displaying data using graphical user interface control elements
    27.
    发明授权
    System and method for displaying data using graphical user interface control elements 失效
    使用图形用户界面控制元素显示数据的系统和方法

    公开(公告)号:US06237004B1

    公开(公告)日:2001-05-22

    申请号:US09028744

    申请日:1998-02-24

    IPC分类号: G06F1730

    CPC分类号: G06F9/451 Y10S707/99943

    摘要: The present invention is a system, method, and computer readable medium for determining which graphic user interface (GUI) control element, including a graphic symbol and associated control code, to use to display particular data. The present invention uses a data-driven model, wherein the GUI control element, referred to as a widget, for a particular set of data is determined dynamically, based on information contained in a database. A widget may be created, displayed, and modified without having to change the program code which uses the widget to display data. As a program executes, it is determined that data needs to be displayed as part of a graphical user interface. The program which is executing calls a generic GUI manager, which determines which widget to use for the particular data at this point in the program and displays the widget. The generic GUI manager reads a database entry associated with the data to be displayed. The database entry contains information, or characteristics, regarding the data. The characteristics are then analyzed by the generic GUI manager to determine which type of widget to use to display the data. An appropriate widget is then selected and used. Both homogenous changes (i.e. graphic symbol changes, where the behavior remains the same) and heterogeneous changes (i.e. where both the graphic symbol and the behavior change) are supported.

    摘要翻译: 本发明是一种系统,方法和计算机可读介质,用于确定用于显示特定数据的图形用户界面(GUI)控制元素,包括图形符号和相关联的控制代码。 本发明使用数据驱动模型,其中,基于数据库中包含的信息,动态地确定用于特定数据集合的称为小部件的GUI控制元素。 可以创建,显示和修改小部件,而无需更改使用小部件显示数据的程序代码。 当程序执行时,确定数据需要作为图形用户界面的一部分显示。 正在执行的程序调用通用GUI管理器,该管理器确定在程序中的这一点处为特定数据使用的窗口小部件,并显示窗口小部件。 通用GUI管理器读取与要显示的数据相关联的数据库条目。 数据库条目包含有关数据的信息或特性。 然后,通用GUI管理器分析特征以确定用于显示数据的哪个类型的小部件。 然后选择并使用适当的小部件。 两个同质变化(即图形符号变化,其中行为保持相同)和异质变化(即图形符号和行为改变两者)都被支持。

    Regulated expression of recombinant proteins from adeno-associated viral vectors
    30.
    发明申请
    Regulated expression of recombinant proteins from adeno-associated viral vectors 审中-公开
    来自腺相关病毒载体的重组蛋白的调节表达

    公开(公告)号:US20070292922A1

    公开(公告)日:2007-12-20

    申请号:US11729341

    申请日:2007-03-28

    摘要: Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing cleavage site between the coding sequence for the first and second immunoglobulin coding sequence and a additional proteolytic cleavage site, which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.

    摘要翻译: 描述了免疫球蛋白分子或其片段的调节表达的单一AAV载体构建体及其制备和使用方法。 AAV载体包含与第一和第二免疫球蛋白编码序列的编码序列可操作地连接的调控启动子,编码第一和第二免疫球蛋白编码序列的编码序列与另外的蛋白水解切割位点之间的自加工切割位点的序列, 其提供了从表达的免疫球蛋白分子或其片段中除去自身加工肽序列的方法。 载体构建体在体外和体内发现在生物活性免疫球蛋白或其片段的增强生产中起作用。