摘要:
Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.
摘要:
A first slot connector is mounted within a housing of an electronic system and is for connecting to a first plug-in card. A mezzanine board is installed within the housing. A second slot connector is mounted on the mezzanine board for connecting to a second plug-in card. The first and second plug-in cards align with similarly-shaped slot access panels in the electronic system.
摘要:
Multivalent soluble receptor proteins that bind to more than one angiogenic factor are described. Nucleotide and vector sequences which encode the multivalent soluble receptor protein, as well as host cells which comprise them and methods of making and using them are also described. The multivalent soluble receptor proteins and vectors which encode them find utility in treatment of cancer and other diseases associated with angiogenesis.
摘要:
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease.
摘要:
A press pin for mounting in a panel structure comprises a central retaining portion adapted to be inserted into an opening in the panel structure, a first end pin feature protruding from a first side of the central retaining portion, and a second end pin feature protruding from a second side of the central retaining portion.
摘要:
A method for providing an electronic business card to a contact via a cellular phone is disclosed. Several business card menu options are provided to a user of a cellular telephone. The cellular phone user enters business card information/data into the cellular phone utilizing the business card menu options. The business card data is stored locally on the cellular phone or in a service provider database. When the user is in communication via cellular phone with someone he wishes to provide his business card to, the user selects a menu item that activates the transmission of the electronic business card to the desired recipient's cellular phone.
摘要:
The present invention is a system, method, and computer readable medium for determining which graphic user interface (GUI) control element, including a graphic symbol and associated control code, to use to display particular data. The present invention uses a data-driven model, wherein the GUI control element, referred to as a widget, for a particular set of data is determined dynamically, based on information contained in a database. A widget may be created, displayed, and modified without having to change the program code which uses the widget to display data. As a program executes, it is determined that data needs to be displayed as part of a graphical user interface. The program which is executing calls a generic GUI manager, which determines which widget to use for the particular data at this point in the program and displays the widget. The generic GUI manager reads a database entry associated with the data to be displayed. The database entry contains information, or characteristics, regarding the data. The characteristics are then analyzed by the generic GUI manager to determine which type of widget to use to display the data. An appropriate widget is then selected and used. Both homogenous changes (i.e. graphic symbol changes, where the behavior remains the same) and heterogeneous changes (i.e. where both the graphic symbol and the behavior change) are supported.
摘要:
The present invention relates to prostate cancer markers, compositions comprising such markers, and methods of using such markers to induce or increase an immune response against prostate cancer. An immune response against the markers correlates with an immune response, in particular a humoral immune response, against prostate cancer cells which immune response is preferably associated with prophylaxis of prostate cancer, treatment of prostate cancer, and/or amelioration of at least one symptom associated with prostate cancer.
摘要:
Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing cleavage site between the coding sequence for the first and second immunoglobulin coding sequence and a additional proteolytic cleavage site, which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.