Method for detecting infectious agents using computer controlled automated image analysis
    22.
    发明申请
    Method for detecting infectious agents using computer controlled automated image analysis 审中-公开
    使用计算机控制的自动图像分析检测感染因子的方法

    公开(公告)号:US20060239533A1

    公开(公告)日:2006-10-26

    申请号:US10543270

    申请日:2002-06-04

    IPC分类号: G06M11/02 G01N33/48 G06K9/00

    摘要: Computer controlled methods, systems and apparatus for detecting an infectious agent in a host cell, an animal cell, or plant cell, a body fluid or tissue sample to provide information useful to diagnose a disease or prognosticate disease susceptibility, extent or outcome are provided. In one illustrative embodiment, the infected animal cell is a Chlamydia infected mononuclear phagocyte in a blood sample. In another illustrative embodiment, the infected body fluid is a blood sample infected with “fee floating” Chlamydia. Detection and preferably, quantification of such an infected mononuclear phagocyte(s) or blood sample provides information useful in diagnosing or prognosticating susceptibility, extent or outcome of patients suspected of suffering from vascular, coronary or central nervous disease(s) or disorder(s).

    摘要翻译: 提供了用于检测宿主细胞,动物细胞或植物细胞,体液或组织样本中的感染剂的计算机控制方法,系统和装置,以提供用于诊断疾病或预测疾病易感性,程度或结果的信息。 在一个说明性实施方案中,感染的动物细胞是血液样品中衣原体感染的单核吞噬细胞。 在另一说明性实施例中,感染的体液是感染“费用漂浮”衣原体的血液样本。 检测并优选地定量这种受感染的单核吞噬细胞或血液样品提供了可用于诊断或预测怀疑患有血管,冠状动脉或中枢神经疾病或病症的患者的易感性,程度或结果的信息, 。

    SYSTEM FOR DETECTING INFECTIOUS AGENTS USING COMPUTER-CONTROLLED AUTOMATED IMAGE ANALYSIS
    23.
    发明申请
    SYSTEM FOR DETECTING INFECTIOUS AGENTS USING COMPUTER-CONTROLLED AUTOMATED IMAGE ANALYSIS 有权
    使用计算机控制自动图像分析检测感染性代理的系统

    公开(公告)号:US20080199948A1

    公开(公告)日:2008-08-21

    申请号:US12052898

    申请日:2008-03-21

    IPC分类号: C12M1/00

    摘要: A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.

    摘要翻译: 公开了一种用于识别图像中的对象的方法,其中通过估计图像中每个像素的分形维数来生成图像的分形图。 可以通过阈值分割分形图并确定候选对象的位置。 可以将对应于在分形图中找到候选对象的相同位置的图像像素的像素值与阈值进行比较。 如果像素值大于阈值,则候选对象被识别为有效对象。

    Slide deposition chamber
    27.
    发明申请
    Slide deposition chamber 审中-公开
    滑动沉积室

    公开(公告)号:US20070009389A1

    公开(公告)日:2007-01-11

    申请号:US11177036

    申请日:2005-07-08

    IPC分类号: B05B1/28 B01L3/00

    摘要: A cell deposition chamber and a method for depositing a biological sample on a microscope slide using the chamber. The chamber is removably sealed onto a sample receiving area on the slide and has a sealable opening to allow aspiration of the sample from the slide surface. The chamber is configured to allow the aspiration of all areas of the slide surface by a pipette and the chamber drains fully when inverted. The chamber can be fitted with a disposable liner to make the chamber reusable.

    摘要翻译: 一种细胞沉积室和使用该腔室将生物样品沉积在显微镜载玻片上的方法。 腔室可移除地密封在载玻片上的样品接收区域上,并且具有可密封的开口以允许样品从滑动表面抽吸。 腔室被配置为允许通过移液管吸取滑动表面的所有区域,并且当倒置时室被完全排出。 该腔室可以安装一次性衬垫,以使腔室可重复使用。

    Process for identifying FISH signals
    28.
    发明授权
    Process for identifying FISH signals 有权
    识别FISH信号的过程

    公开(公告)号:US07660454B2

    公开(公告)日:2010-02-09

    申请号:US11685736

    申请日:2007-03-13

    IPC分类号: G06K9/00

    摘要: The invention herein includes a method for combining immuno staining and FISH using covalently bound small molecule tags. Among embodiments included are methods of tagging immuno and FISH probes for treatment of biologic material. Embodiments comprise directing the fluorescently labeled immuno probe(s) to non-chromosomic portions of a biologic sample and directing labeled FISH probe(s) to chromosomic portions of the biologic sample for further identification of subcellular components. Embodiments also comprise the automatic connection of information regarding the sample to image analysis, to subcellular component identification and enumeration in order to affect biomedical decisions.

    摘要翻译: 本发明包括使用共价结合的小分子标签组合免疫染色和FISH的方法。 包括的实施方案是标记用于治疗生物材料的免疫和FISH探针的方法。 实施方案包括将荧光标记的免疫探针引导到生物样品的非染色体部分,并将标记的FISH探针引导到生物样品的染色体部分,以进一步鉴定亚细胞组分。 实施例还包括将样品与图像分析相关的信息自动连接到亚细胞组分鉴定和计数以便影响生物医学决定。