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公开(公告)号：US20090071267A1
公开(公告)日：2009-03-19
申请号：US11856193
申请日：2007-09-17
申请人： Greg Mathus , Richard Cote
发明人： Greg Mathus , Richard Cote
CPC分类号： B01L3/0227 , B01L3/0279 , B01L2200/087
摘要： An ejection mechanism for a hand-held pipettor provides for varying degrees of mechanical advantage along the stroke of the ejector button. The ejection mechanism can be used for either hand-held single channel pipettors or hand-held multi-channel pipettors having manually actuated ejection mechanisms.
摘要翻译： 用于手持式移液器的排出机构提供沿喷射器按钮的行程的不同程度的机械优点。 喷射机构可用于手持单通道移液器或具有手动驱动的排出机构的手持式多通道移液器。
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公开(公告)号：US20180117584A1
公开(公告)日：2018-05-03
申请号：US14131278
申请日：2012-07-09
申请人： Richard Cote
发明人： Richard Cote
CPC分类号： B01L3/5025 , B01L3/0217 , B01L3/0275 , B01L3/5635 , B01L2200/021 , B01L2200/023 , B01L2200/025 , B01L2200/026 , B01L2300/0829
摘要： An adapter for connecting an array of pipette tips having through bores with conical upper ends to a multichannel air displacement pipettor having a plurality of ports with compliant internal sealing surfaces. The adapter comprises a planar base with an array of openings extending between its top and bottom surfaces. Sealing tubes project upwardly from the top surface, and tip mounting tubes project downwardly from the bottom surface, with pairs of sealing tubes and tip mounting tubes being arranged coaxially and in communication with respective ones of the openings in the base. The tip mounting tubes are externally dimensioned and configured for insertion into the conical upper ends of the pipette tips, and the sealing tubes are externally configured and dimensioned for insertion into the ports of the pipettor and into sealing interengagement with their compliant internal sealing surfaces.
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23.发明申请公开(公告)号：US20150086447A1
公开(公告)日：2015-03-26
申请号：US14524685
申请日：2014-10-27
申请人： Gregory Mathus , Terrence Kelly , Richard Cote
发明人： Gregory Mathus , Terrence Kelly , Richard Cote
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L3/0275 , B01L3/0279 , B01L2200/023 , B01L2200/025 , B01L2200/0689 , B01L2200/087 , B01L2300/027 , Y10T137/0318 , Y10T436/2575
摘要： The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.
摘要翻译： 移液方法涉及安装和喷射一次性吸头。 移液系统具有一个或多个具有上部锁定部分和下部密封部分的尖端安装轴。 上锁定部分具有围绕安装轴间隔开并位于止动件上方的向外延伸的凸角。 刀片安装轴上的下密封部分位于挡块下方。 当安装轴插入到一次性移液管的轴环中时，套环从圆形变形并与尖端安装轴的上部锁定部分上的凸角接合。 同时，安装轴的下密封部分密封在一次性移液管尖端的筒体上。
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公开(公告)号：US08128892B2
公开(公告)日：2012-03-06
申请号：US13219823
申请日：2011-08-29
CPC分类号： B01L3/0237 , B01L3/0217 , B01L3/0227 , B01L2200/022
摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.
摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。
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公开(公告)号：US20100034706A1
公开(公告)日：2010-02-11
申请号：US12578714
申请日：2009-10-14
申请人： Gregory Mathus , Terrence Kelly , Richard Cote
发明人： Gregory Mathus , Terrence Kelly , Richard Cote
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L3/0275 , B01L3/0279 , B01L2200/023 , B01L2200/025 , B01L2200/0689 , B01L2200/087 , B01L2300/027 , Y10T137/0318 , Y10T436/2575
摘要： In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.
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公开(公告)号：US07540205B2
公开(公告)日：2009-06-02
申请号：US11856231
申请日：2007-09-17
申请人： Gary E. Nelson , George P. Kalmakis , Joel Novak , Kenneth Steiner , Jonathon Finger , Richard Cote
发明人： Gary E. Nelson , George P. Kalmakis , Joel Novak , Kenneth Steiner , Jonathon Finger , Richard Cote
IPC分类号： G01N1/00
CPC分类号： B01L3/0234 , B01L2200/0605 , B01L2200/087 , B01L2200/148
摘要： A hand-held electronic pipettor is designed particularly to be programmed and operated with one hand for the convenience of the user. It uses a capacitance touchpad control for programming, and a separate run button for the operating mode. Internal components are located so that the center of gravity of the pipettor is located within the palm of the user. Flash memory stores an empirically derived table that correlates aspiration volume to motor steps and a separate empirically derived table the correlates dispensing volumes to motor steps.
摘要翻译： 手持式电子移液器特别设计为一方面进行编程和操作，方便用户使用。 它使用电容式触摸板控件进行编程，另外还有一个运行模式的运行按钮。 内部部件被定位成使得移液器的重心位于使用者的手掌内。 闪存存储经验导出的表，其将抽吸体积与运动步骤相关联，以及单独的经验派生表将分配体积与运动步骤相关联。
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公开(公告)号：US20090071266A1
公开(公告)日：2009-03-19
申请号：US11856231
申请日：2007-09-17
申请人： Gary E. Nelson , George P. Kalmakis , R. Laurence Keene , Joel Novak , Kenneth Steiner , Jonathon Finger , Gregory Mathus , Richard Cote
发明人： Gary E. Nelson , George P. Kalmakis , R. Laurence Keene , Joel Novak , Kenneth Steiner , Jonathon Finger , Gregory Mathus , Richard Cote
CPC分类号： B01L3/0234 , B01L2200/0605 , B01L2200/087 , B01L2200/148
摘要： A hand-held electronic pipettor is designed particularly to be programmed and operated with one hand for the convenience of the user. It uses a capacitance touchpad control for programming, and a separate run button for the operating mode. Internal components are located so that the center of gravity of the pipettor is located within the palm of the user. Flash memory stores an empirically derived table that correlates aspiration volume to motor steps and a separate empirically derived table the correlates dispensing volumes to motor steps.
摘要翻译： 手持式电子移液器特别设计为一方面进行编程和操作，方便用户使用。 它使用电容式触摸板控件进行编程，另外还有一个运行模式的运行按钮。 内部部件被定位成使得移液器的重心位于使用者的手掌内。 闪存存储经验导出的表，其将抽吸体积与运动步骤相关联，以及单独的经验派生表将分配体积与运动步骤相关联。
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公开(公告)号：US20080286157A1
公开(公告)日：2008-11-20
申请号：US11934381
申请日：2007-11-02
申请人： Gregory Mathus , Terrence Kelly , Richard Cote
发明人： Gregory Mathus , Terrence Kelly , Richard Cote
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L3/0275 , B01L3/0279 , B01L2200/023 , B01L2200/025 , B01L2200/0689 , B01L2200/087 , B01L2300/027 , Y10T137/0318 , Y10T436/2575
摘要： In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.
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公开(公告)号：US20060027033A1
公开(公告)日：2006-02-09
申请号：US10903448
申请日：2004-07-30
申请人： Richard Cote , Robert Zier , Craig Weiss , William Frazier
发明人： Richard Cote , Robert Zier , Craig Weiss , William Frazier
IPC分类号： B01L3/02
CPC分类号： B01L3/0227 , B01L3/0237
摘要： A hand-held pipette is disclosed including a pipette tip, a piston, and a voice recognition and control system. The pipette tip is provided at one end of an elongated enclosure. The piston is received in an opposite end of the elongated enclosure. The piston is adapted for reciprocal movement within at least a portion of the elongated enclosure through a selected first stroke to aspirate a first volume of fluid into the pipette tip and to expel the thus aspirated first volume of fluid out of the pipette tip. The voice recognition and control system is for automatically adjusting the stroke of the piston from the first stroke to a second stroke responsive to voice commands such that a second volume of fluid may be aspirated into the pipette tip and the thus aspirated second volume of fluid may be expelled out of the pipette tip.
摘要翻译： 公开了一种手持式移液器，其包括吸头，活塞和语音识别和控制系统。 移液管尖端设置在细长外壳的一端。 活塞被容纳在细长外壳的相对端。 活塞适于在细长外壳的至少一部分内通过所选择的第一冲程往复运动，以将第一体积的流体吸入移液管吸头中，并将由此吸出的第一体积的流体排出移液管尖端。 语音识别和控制系统用于响应于语音命令自动地将活塞的冲程从第一冲程调整到第二冲程，使得第二体积的流体可以被吸入移液管尖端，并且由此吸出的第二体积的流体可以 被排出移液器吸头。
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公开(公告)号：US08518345B2
公开(公告)日：2013-08-27
申请号：US13411675
申请日：2012-03-05
CPC分类号： B01L3/0237 , B01L3/0217 , B01L3/0227 , B01L2200/022
摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.
摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。
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