Co-axial plunger based home molecular diagnostics kit

    公开(公告)号:US11833519B2

    公开(公告)日:2023-12-05

    申请号:US17240767

    申请日:2021-04-26

    CPC classification number: B01L7/52 B01L3/0217 B01L3/5023

    Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.

    Dual resolution liquid handling
    5.
    发明授权

    公开(公告)号:US11813606B2

    公开(公告)日:2023-11-14

    申请号:US17942105

    申请日:2022-09-09

    Abstract: The present disclosure provides better aspiration and dispensing of liquids by an innovative mechanism by (i) offsetting the diameter of a bottom tube with a narrower and tapered top piston when the two are moved together in the same chamber to give extremely fine resolution, thereby eliminating the need for any skinny or filamentous piston, (ii) using thick walled compliant O-rings to seal against the different diameters of the tapered piston to given an additional order of magnitude range of resolution, (iii) letting the bottom tube move in the chamber alone without offset to give high flow, and (iv) an at-the-ready space between the tube and piston in the chamber to permit contact-free blowoff, including viscous samples.

    Pipette for volumetrically metering powder

    公开(公告)号:US10071372B2

    公开(公告)日:2018-09-11

    申请号:US14943798

    申请日:2015-11-17

    Inventor: Steffen Nitsch

    CPC classification number: B01L3/0217 A61J3/074 B65B1/36 B65B1/38 G01F11/10

    Abstract: A pipette for volumetrically metering powder includes an outer metering casing enclosing a metering chamber. The metering casing defines a free end of the pipette whereat the metering casing forms an opening. The metering chamber has an opposite end lying opposite to the free end of the pipette and the opposite end of the metering chamber is delimited by an air-permeable retaining element. The retaining element is configured as a flexible filter defining a plane and having a back side facing away from the metering chamber. An air-permeable support core supports the filter at the back side thereof and is rigid transversely to the plane of the filter.

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