公开(公告)号：US06982063B2

公开(公告)日：2006-01-03

申请号：US09865404

申请日：2001-05-25

申请人： Marc F. Hamel ,  Greg Mathus ,  Richard Cote ,  Yoshio Maeda ,  Chikashi Ohtomo

发明人： Marc F. Hamel ,  Greg Mathus ,  Richard Cote ,  Yoshio Maeda ,  Chikashi Ohtomo

IPC分类号： B01L3/02 ,  G01N1/10 ,  G01N21/00

CPC分类号： G01N35/1002 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1067 ,  G01N35/1074 ,  G01N2035/0425 ,  G01N2035/1069 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A highly automated, high volume multichannel pipetting system which transfers liquid from mother plates to daughter plates, or from a fill station to daughter plates. The mother plates are stacked in one set of stacker assemblies, while the empty daughter plates are stacked in another stacker assembly. A plate handling assembly which is capable of moving the plates in three orthogonal directions retrieves the plates from the stacker assemblies, carries them to the pipetting head, and returns them to other stacker assemblies. The pipetting head is removable for replacement or repair thereof, or for insertion of another head assembly having a different number of pipetting channels. The head slides into the housing on slideways, and is retained in place by manually operable, threaded knobs mounted on shafts. The stacker assemblies include a chimney which is removable from a base. The plates may be stacked in the chimney and then inserted on the base. The base includes solenoids whose arms are retractable to permit plates to be retrieved or replaced one at a time. The chimneys contain flaps which serve to retain the plates within the chimney if manually removed from the base. Doors in the stacker chimneys allow manual insertion and replacement of plates. Methods of operation of the pipetting system are also disclosed.

公开(公告)号：US20090071267A1

公开(公告)日：2009-03-19

申请号：US11856193

申请日：2007-09-17

申请人： Greg Mathus ,  Richard Cote

发明人： Greg Mathus ,  Richard Cote

IPC分类号： G01N1/14 ,  B01L3/02

CPC分类号： B01L3/0227 ,  B01L3/0279 ,  B01L2200/087

摘要： An ejection mechanism for a hand-held pipettor provides for varying degrees of mechanical advantage along the stroke of the ejector button. The ejection mechanism can be used for either hand-held single channel pipettors or hand-held multi-channel pipettors having manually actuated ejection mechanisms.

摘要翻译： 用于手持式移液器的排出机构提供沿喷射器按钮的行程的不同程度的机械优点。 喷射机构可用于手持单通道移液器或具有手动驱动的排出机构的手持式多通道移液器。

公开(公告)号：US06669432B2

公开(公告)日：2003-12-30

申请号：US09928782

申请日：2001-08-13

申请人： Marc Hamel ,  Greg Mathus ,  Michael F. LaCourse ,  Robert H. Hunt ,  Mark Dumont

发明人： Marc Hamel ,  Greg Mathus ,  Michael F. LaCourse ,  Robert H. Hunt ,  Mark Dumont

IPC分类号： G01N3502

CPC分类号： G01N35/10 ,  B01L9/543 ,  G01N35/028 ,  G01N35/1074 ,  G01N2035/0484 ,  G01N2035/103

摘要： A method and apparatus for automatically removing used magazines with used pipette tips from a pipetting head in an automated pipettor, and for automatically inserting an unused or cleaned magazine with unused or cleaned pipette tips in their place. The apparatus includes a gripping mechanism having two separate and independently operated gripping heads, one gripping head being associated exclusively with unused or cleaned magazines and pipetting tips, and the other gripping head being associated exclusively with used magazines and pipette tips. A transporting mechanism is provided for moving the gripping heads between the pipetting head, a disposal mechanism, and a supply of unused or cleaned magazines and pipetting tips. The supply preferably includes a carousel with a multiplicity of locations for storing unused or cleaned magazines and tips in a vertical alignment. The carousel is rotated so that a compartment containing unused or cleaned magazines and tips is in alignment with an opening in the carousel. The gripping head automatically scans the carousel looking for the next available unused or cleaned magazine and tips for transport to the pipetting head. Another scanning mechanism locates the used magazine in the pipetting head for removal. The method includes the steps of withdrawing a used magazine and tips from a pipetting head, inserting unused or cleaned magazine and tips in the pipetting head, and transporting the used magazine and tips to a disposal location. The method also includes the step of automatically retrieving unused or cleaned magazines and tips from a storage location for transport to the pipetting head.

摘要翻译： 一种用于在自动移液器中从移液头自动移除二手杂志的方法和装置，以及用于在其位置自动插入未使用或清洁的杂物盒，其中未使用或清洁的移液管吸头。 该装置包括具有两个单独和独立操作的夹紧头的夹紧机构，一个夹头仅与未使用或清洁的杂志和移液头相关联，而另一个夹头仅与使用过的杂志和吸头相关联。 提供了一种传送机构，用于使抓持头在移液头，处置机构和未使用或清洁的杂志和移液头之间的移动。 该供应优选地包括具有多个位置的转盘，用于在垂直对准中存储未使用或清洁的杂志和尖端。 旋转盘旋转，使得包含未使用或清洁的杂志和尖端的隔间与转盘中的开口对齐。 夹头自动扫描转盘，寻找下一个可用的未使用或清洁的杂志和提示，以便运送到移液头。 另一种扫描机构将使用的杂志定位在移液头中以便移除。 该方法包括以下步骤：从移液头中取出用过的杂物和尖端，将未使用或清洁的杂志和尖端插入到移液头中，以及将所使用的杂志和尖端传送到处置位置。 该方法还包括从存储位置自动检索未使用或清洁的杂志和提示以便运送到移液头的步骤。

公开(公告)号：US07811522B2

公开(公告)日：2010-10-12

申请号：US11773819

申请日：2007-07-05

申请人： Greg Mathus ,  Terrence Kelly

发明人： Greg Mathus ,  Terrence Kelly

IPC分类号： B65D21/00 ,  B65H1/00

CPC分类号： B01L3/508 ,  B01L3/021 ,  B01L3/505 ,  B01L2300/028 ,  B01L2300/0854

摘要： A liquid sample or liquid reagent reservoir kit employs a reusable reservoir base and disposable liners made of a clear transparent plastic material. Graduation marks are located on the sidewall surface of the basin in the reusable reservoir base, and are calibrated to measure liquid volumes in a disposable liner placed within the reusable reservoir base. The transparency of the clear disposable liner allows the liquid volume graduation marks on the sidewall of the basin in the reusable base to be observed through the disposable liner. The disposable liners are configured so that the liners can also be used as a cover. The geometry of the disposable liners facilitates tight nesting of stacked liners to facilitate shipping as well as storage on the laboratory bench top.

摘要翻译： 液体样品或液体试剂储存器套件采用可重复使用的储存器底座和由透明透明塑料材料制成的一次性衬垫。 刻度标记位于可重复使用的储存器底座中的盆的侧壁表面上，并且被校准以测量放置在可重复使用的储存器底座内的一次性衬垫中的液体体积。 透明一次性衬垫的透明度允许通过一次性衬垫观察可重复使用的底座中的盆的侧壁上的液体体积刻度。 一次性衬垫被构造成使得衬垫也可以用作罩。 一次性衬垫的几何形状有助于堆叠衬垫的紧密嵌套，以便于运输以及实验室台面上的储存。

公开(公告)号：US20090008405A1

公开(公告)日：2009-01-08

申请号：US11773819

申请日：2007-07-05

申请人： Greg Mathus ,  Terrence Kelly

发明人： Greg Mathus ,  Terrence Kelly

IPC分类号： B65D21/00 ,  B01L3/00 ,  B65H1/00

CPC分类号： B01L3/508 ,  B01L3/021 ,  B01L3/505 ,  B01L2300/028 ,  B01L2300/0854

摘要： A liquid sample or liquid reagent reservoir kit employs a reusable reservoir base and disposable liners made of a clear transparent plastic material. Graduation marks are located on the sidewall surface of the basin in the reusable reservoir base, and are calibrated to measure liquid volumes in a disposable liner placed within the reusable reservoir base. The transparency of the clear disposable liner allows the liquid volume graduation marks on the sidewall of the basin in the reusable base to be observed through the disposable liner. The disposable liners are configured so that the liners can also be used as a cover. The geometry of the disposable liners facilitates tight nesting of stacked liners to facilitate shipping as well as storage on the laboratory bench top.

摘要翻译： 液体样品或液体试剂储存器套件采用可重复使用的储存器底座和由透明透明塑料材料制成的一次性衬垫。 刻度标记位于可重复使用的储存器底座中的盆的侧壁表面上，并且被校准以测量放置在可重复使用的储存器底座内的一次性衬垫中的液体体积。 透明一次性衬垫的透明度允许通过一次性衬垫观察可重复使用的衬底中的盆的侧壁上的液体体积刻度。 一次性衬垫被构造成使得衬垫也可以用作罩。 一次性衬垫的几何形状有助于堆叠衬垫的紧密嵌套，以便于运输以及实验室台面上的储存。