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21.发明授权Method and apparatus for sodding microvessel cells onto a synthetic vascular graft 失效将微血管细胞浸泡在合成血管移植物上的方法和装置
公开(公告)号：US5804366A
公开(公告)日：1998-09-08
申请号：US386048
申请日：1995-02-09
申请人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
发明人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
CPC分类号： A61F2/062 , A61L27/507 , Y10S623/921
摘要： An apparatus for sodding onto the inner lumenal surface of a synthetic graft of harvested and concentrated microvessel endothelial cells from liposuctioned fat tissues, which harvested cells are formed into a "pellet" of isolated endothelial cells in loose aggregations, includes a sodding tube having a single rigid outer wall bounding a sodding chamber. A filter pack assembly is provided to communicate the pellet of cells from a processing vessel to the graft. This filter pack assembly includes a series of successively finer filter members cooperatively defining a series of turbulent-flow chambers in which aggregations of cells too large to pass through a particular filter are exposed to liquid flow turbulence which is effective to break up the aggregations. A check valve assembly ensures that liquid flow is unidirectional so that sodding of the cells onto the inner lumenal surface of the graft is not interfered with by possible liquid reflux, and sodded cells are similarly not dislodged from the graft by such liquid reflux.
摘要翻译： 将收集的细胞收集和浓缩的微血管内皮细胞的合成移植物的内腔表面上的沉淀物形成为松散聚集的分离的内皮细胞的“沉淀”的装置，包括具有单个 刚性外墙围住了一个饮料室。 提供过滤器组件以将细胞团从处理容器传递到移植物。 该过滤器组件包括一系列相继更细的过滤器构件，其协作地限定一系列湍流室，其中太大而不能通过特定过滤器的单元的聚集物暴露于有效破坏聚集的液体流动湍流。 止回阀组件确保液体流动是单向的，使得细胞在移植物的内腔表面上的唾液分解不会被可能的液体回流干扰，并且经过这种液体回流的同样，细胞也不会从移植物移出。
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公开(公告)号：US20100081868A1
公开(公告)日：2010-04-01
申请号：US12567532
申请日：2009-09-25
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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公开(公告)号：US07594887B2
公开(公告)日：2009-09-29
申请号：US11876586
申请日：2007-10-22
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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24.发明申请公开(公告)号：US20050288780A1
公开(公告)日：2005-12-29
申请号：US11124405
申请日：2005-05-06
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have, a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译： 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。
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公开(公告)号：US6071307A
公开(公告)日：2000-06-06
申请号：US163831
申请日：1998-09-30
申请人： Richard Rhee , John McIntyre , Seik Oh
发明人： Richard Rhee , John McIntyre , Seik Oh
CPC分类号： A61F2/07 , A61F2/95 , A61F2/89 , A61F2002/075 , A61F2250/001
摘要： An endoluminal grafts is provided which is constructed to be radially collapsed and/or radially compressed to a small diameter. The graft has wireforms which generally comprise a wire deformed into generally annular configuration and consisting of a plurality of curvilinear wave forms. The wave forms have a plurality of first apices in linear alignment with each other, a plurality of second apices in linear alignment with each other, and a plurality of curvilinear segments traversing back and forth between said first and second apices. The graft is i) initially disposable in a radially compact configuration of a first diameter and ii) subsequently expandable to a radially expanded configuration of a second diameter, said second diameter being larger than said first diameter. When in its radially compact configuration, the adjacent curvilinear segments of the wireforms will nest or seat in abutting contact with one another, thereby minimizing the diameter of the graft while in its radially compact configuration.
摘要翻译： 提供了一种腔内移植物，其构造成径向塌缩和/或径向压缩至小直径。 移植物具有线形，其通常包括变形为大致环形构型并由多个曲线波形组成的线。 波形具有彼此线性对准的多个第一顶点，彼此线性对齐的多个第二顶点和在所述第一和第二顶点之间往复运动的多个曲线段。 移植物是i）最初一次性处于第一直径的径向致密构造中，并且ii）随后可扩张至第二直径的径向扩张构型，所述第二直径大于所述第一直径。 当处于其径向紧凑的构造中，线形的相邻曲线段将彼此嵌套或抵靠接触，从而使其在径向紧凑的构型中最小化移植物的直径。
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公开(公告)号：US07285087B2
公开(公告)日：2007-10-23
申请号：US11142078
申请日：2005-05-31
IPC分类号： A61F2/00
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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公开(公告)号：US20050043791A1
公开(公告)日：2005-02-24
申请号：US10868470
申请日：2004-06-14
申请人： Patrick McCarthy , Richard Rhee , Stefan Schreck
发明人： Patrick McCarthy , Richard Rhee , Stefan Schreck
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2/2466 , A61M25/001 , A61M25/0032 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0138 , A61M2025/0002 , A61M2025/0003 , A61M2025/0004 , A61M2025/0081
摘要： An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring. The template may have an outwardly-facing groove to receive and retain the ring.
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公开(公告)号：US5814096A
公开(公告)日：1998-09-29
申请号：US960083
申请日：1997-10-24
申请人： Hung Lam , Lisa Deseran , Richard Rhee
发明人： Hung Lam , Lisa Deseran , Richard Rhee
CPC分类号： A61F2/2496 , A61B5/1076 , A61F2/2427 , A61B90/06
摘要： An aortic valve sizing obturator apparatus for employment in determining the correct size of an aortic annulus. The apparatus includes a cylindrical obturator body with a flange member formed thereabout. At least the under surface of the flange member is of a non-planar, multi-curvate configuration to thereby be complimentary in shape to the annulus of an aortic valve when seated in the annulus during size determination. Within the cylindrical obturator body can be disposed a handle connector to which a handle can be attached during placement of the obturator apparatus within an annulus. The present invention also includes methodology for determining the size of an aortic valve annulus by employing a plurality of differently-sized aortic valve sizing obturators defined above and individually seating them sequentially within the aortic annulus until an obturator that reflects annulus size is located.
摘要翻译： 主动脉瓣尺寸闭塞装置用于确定主动脉瓣的正确尺寸。 该装置包括圆柱形封闭体，其上形成有凸缘部件。 凸缘构件的至少下表面具有非平面的多弯曲构造，从而在尺寸确定期间坐在环形空间中时，其形状与主动脉瓣的环形互补。 在圆柱形闭塞体内部可以设置手柄连接器，在将闭塞装置放置在环形空间内时可将手柄附接到手柄连接器。 本发明还包括通过采用多个不同大小的主动脉瓣尺寸闭塞器来确定主动脉瓣环的尺寸的方法，并且将它们依次单独地安置在主动脉瓣环内直到反映环空尺寸的闭孔器。
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公开(公告)号：US5800531A
公开(公告)日：1998-09-01
申请号：US723420
申请日：1996-09-30
申请人： Delos M. Cosgrove , Richard Rhee , Diana Nguyen
发明人： Delos M. Cosgrove , Richard Rhee , Diana Nguyen
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2427 , Y10S623/90
摘要： In general, the present invention comprises an holding apparatus for facilitating implantation of a prosthetic heart valve within a mammalian heart. The holding apparatus generally comprises a cage or enclosure having a heart valve prosthesis retention space defined therewith. The proximal end of the holding apparatus is releasably attached to the proximal end of the heart valve prosthesis such that, when the holding apparatus is advanced in a forward direction, a "pulling" force will be exerted upon the proximal end of the prosthesis, rather than a "pushing" force being exerted upon the distal end of the prosthesis. The releasable attachment of the prosthesis to the holding apparatus may be accomplished by any suitable attachment member, and preferably comprises a number of suture threads which are passed through the prosthesis and threaded upon the holding apparatus at location(s) which are easily accessible such that the surgeon may cut the suture threads to effect release of the heart valve prosthesis, during the prosthesis implantation procedure. Also described and claimed are associated methods for utilizing the above-described holding apparatus to effect implantation of a prosthetic heart valve.
摘要翻译： 通常，本发明包括一种用于便于在哺乳动物心脏内植入假体心脏瓣膜的保持装置。 保持装置通常包括具有与其限定的心脏瓣膜假体保持空间的保持架或外壳。 保持装置的近端可释放地附接到心脏瓣膜假体的近端，使得当保持装置向前推进时，“拉”力将施加在假体的近端，而不是 而不是施加在假体远端的“推动”力。 假体可释放地附接到保持装置可以通过任何适当的附接构件来实现，并且优选地包括多个缝合线，其穿过假体并且在容易接近的位置处被拧到保持装置上，使得 在假体植入过程期间，外科医生可以切割缝合线以实现心脏瓣膜假体的释放。 还描述和要求保护的是用于利用上述保持装置实现假体心脏瓣膜植入的相关方法。
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公开(公告)号：US5409833A
公开(公告)日：1995-04-25
申请号：US86778
申请日：1993-07-01
申请人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
发明人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
CPC分类号： C12M45/09 , A61F2/062 , C12M45/05 , A61M2202/08 , A61M2202/097
摘要： A processing vessel for isolating microvessel endothelial cells from liposuctioned fat tissues includes a fat-receiving basket defined by polyester screen material. Fat tissue removed from a patient by liposuction is received into the basket and is rinsed and digested with an enzymatic solution. The freed microvessel endothelial cells from the fat tissues are separated from the fat cells, and from blood cells and other materials which may be present in the basket by centrifuging. A bottom chamber of the processing vessel is configured to define a "pellet" of isolated endothelial cells which may be removed from the processing vessel for deposition on the inner lumenal surface of a synthetic graft which the fat-donor patient is to receive.
摘要翻译： 用于从脂肪抽吸的脂肪组织分离微血管内皮细胞的处理容器包括由聚酯筛网材料限定的脂肪接收篮。 通过吸脂从患者中取出的脂肪组织被接收到篮中，并用酶溶液冲洗和消化。 来自脂肪组织的释放的微血管内皮细胞从脂肪细胞以及血细胞和其它可能通过离心存在于筐中的物质中分离出来。 处理容器的底部室被配置为限定分离的内皮细胞的“沉淀”，其可以从处理容器中移除，以沉积在供体患者将要接收的合成移植物的内腔表面上。
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