利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.062 秒)

    Vascular endothelial growth factor-2
    21.
    发明授权
    Vascular endothelial growth factor-2 失效
    血管内皮生长因子-2

    公开(公告)号：US07273751B2

    公开(公告)日：2007-09-25

    申请号：US09921143

    申请日：2001-08-03

    申请人： Timothy A. Coleman

    发明人： Timothy A. Coleman

    IPC分类号： C12N15/63

    CPC分类号： C07K14/52 ,  A01K2217/05 ,  A01K2217/075 ,  A61K48/00

    摘要： Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译： 公开了人VEGF-2多肽，生物活性，诊断学或治疗上有用的片段，类似物或其衍生物，以及编码这种VEGF-2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这些多肽和多核苷酸可用于治疗刺激伤口愈合和血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

    Engineering intracellular sialylation pathways
    24.
    发明申请
    Engineering intracellular sialylation pathways 有权
    工程细胞内唾液酸化途径

    公开(公告)号：US20110229931A1

    公开(公告)日：2011-09-22

    申请号：US12806292

    申请日：2010-08-09

    申请人： Donald Jarvis ,  Michael J. Betenbaugh ,  Shawn Lawrence ,  Yuan C. Lee ,  Timothy A. Coleman

    发明人： Donald Jarvis ,  Michael J. Betenbaugh ,  Shawn Lawrence ,  Yuan C. Lee ,  Timothy A. Coleman

    IPC分类号： C12P21/00 ,  C12N15/85 ,  C12N15/80 ,  C12N15/82 ,  C12P19/30 ,  C12N5/10 ,  C07K2/00

    CPC分类号： C12P21/005 ,  C12N15/52

    摘要： Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.

    摘要翻译： 提供了在感兴趣的细胞中操纵碳水化合物处理途径的方法。 方法是通过使用重组DNA技术和底物进料方法来操纵唾液酸化反应所涉及的多个途径，以使得能够在感兴趣的细胞中产生唾液酸化糖蛋白。 这些碳水化合物工程的努力包括实施新的碳水化合物生物测定，检查昆虫细胞系的选择以及使用生物信息学来鉴定关键加工酶的基因序列。 组合物包含感兴趣的细胞产生唾液酸化糖蛋白。 所述方法和组合物可用于糖蛋白的异源表达。

    Endothelial-monocyte activating polypeptide III
    25.
    发明授权
    Endothelial-monocyte activating polypeptide III 失效

    公开(公告)号：US06864226B1

    公开(公告)日：2005-03-08

    申请号：US08972301

    申请日：1997-11-18

    申请人： Timothy A. Coleman ,  Craig A. Rosen

    发明人： Timothy A. Coleman ,  Craig A. Rosen

    IPC分类号： C07K14/52 ,  A61K38/16 ,  C07K14/435

    CPC分类号： C07K14/52

    摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    Human glycosylation enzymes
    26.
    发明授权
    Human glycosylation enzymes 失效
    人类糖基化酶

    公开(公告)号：US06783971B2

    公开(公告)日：2004-08-31

    申请号：US09984205

    申请日：2001-10-29

    申请人： Timothy A. Coleman ,  Michael J. Betenbaugh

    发明人： Timothy A. Coleman ,  Michael J. Betenbaugh

    IPC分类号： C12N988

    CPC分类号： C12N9/1241 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/88 ,  C12N2799/026

    摘要： The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylation enzyme polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human glycosylation enzyme polypeptides.

    摘要翻译： 本发明涉及新的人糖基化酶多肽和含有编码这些多肽的基因的编码区的分离的核酸。 还提供了用于产生人糖基化酶多肽的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人糖基化酶多肽有关的病症的诊断和治疗方法。

    Human growth hormone
    27.
    发明授权
    Human growth hormone 失效
    人类生长激素

    公开(公告)号：US06566328B1

    公开(公告)日：2003-05-20

    申请号：US09411657

    申请日：1999-10-04

    申请人： Craig A. Rosen ,  Timothy A. Coleman ,  Mark D. Adams ,  Jeannine D. Gocayne

    发明人： Craig A. Rosen ,  Timothy A. Coleman ,  Mark D. Adams ,  Jeannine D. Gocayne

    IPC分类号： A01N3718

    CPC分类号： C07K14/61 ,  A61K38/00

    摘要： The present invention relates to a method of treatment of patients by administration of human growth hormone. Also disclosed are DNA (or RNA) polynucleotide sequences that encode naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGV-3(53), as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type human growth hormone. The growth hormone variants of the present invention are of human origin and are useful for diagnostic, preventive and therapeutic purposes with respect to certain human diseases. Also disclosed is a method for producing the human growth hormone variants of the present invention by recombinant DNA techniques, as well as a method for generating antibodies directed against (and therefore inhibiting the activity of) wild-type growth hormone.

    摘要翻译： 本发明涉及通过给予人生长激素治疗患者的方法。 还公开了编码人生长激素，hGHV-2（88）和hGV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列，以及其类似物和衍生物，其都缺乏通常存在的核苷酸序列 在编码野生型人生长激素的基因中。 本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断，预防和治疗目的是有用的。 还公开了通过重组DNA技术生产本发明的人生长激素变体的方法，以及用于产生针对（因此抑制）野生型生长激素的抗体的方法。

    Human criptin growth factor
    28.
    发明授权
    Human criptin growth factor 失效
    人类criptin生长因子

    公开(公告)号：US5981215A

    公开(公告)日：1999-11-09

    申请号：US471371

    申请日：1995-06-06

    申请人： Paul S. Meissner ,  Timothy A. Coleman

    发明人： Paul S. Meissner ,  Timothy A. Coleman

    IPC分类号： A61K48/00 ,  C07K14/475 ,  C07K14/52 ,  C12N15/18 ,  C12N5/10 ,  C12N15/11

    CPC分类号： C07K14/52 ,  C07K14/475 ,  A61K48/00

    摘要： A human Criptin Growth Factor polypeptide (CGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonist against such polypeptides and their use as a therapeutic to treat and/or prevent neoplasia such as tumors is also disclosed. Diagnostic assays for identifying mutations in CGF nucleic acid sequences and altered levels of the CGF for the detection of cancer are also disclosed.

    摘要翻译： 公开了编码这种多肽的人类Criptin生长因子多肽（CGF）和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽用于伤口愈合或组织再生，刺激植入物固定和血管发生的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗和/或预防肿瘤形成如肿瘤的治疗剂的用途。 还公开了用于鉴定CGF核酸序列突变和用于检测癌症的CGF的改变水平的诊断测定。

    Engineering Intracellular Sialylation Pathways
    30.
    发明申请
    Engineering Intracellular Sialylation Pathways 有权
    工程细胞内唾液酸通路

    公开(公告)号：US20090226968A1

    公开(公告)日：2009-09-10

    申请号：US12394479

    申请日：2009-02-27

    申请人： Michael J. Betenbaugh ,  Shawn Lawrence ,  Yuan C. Lee ,  Timothy A. Coleman

    发明人： Michael J. Betenbaugh ,  Shawn Lawrence ,  Yuan C. Lee ,  Timothy A. Coleman

    IPC分类号： C12P21/00 ,  C12N9/00

    CPC分类号： C12P21/005 ,  C12N15/52

    摘要： Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.

    摘要翻译： 提供了在感兴趣的细胞中操纵碳水化合物处理途径的方法。 方法是通过使用重组DNA技术和底物进料方法来操纵唾液酸化反应所涉及的多个途径，以使得能够在感兴趣的细胞中产生唾液酸化糖蛋白。 这些碳水化合物工程的努力包括实施新的碳水化合物生物测定，检查昆虫细胞系的选择以及使用生物信息学来鉴定关键加工酶的基因序列。 组合物包含感兴趣的细胞产生唾液酸化糖蛋白。 所述方法和组合物可用于糖蛋白的异源表达。