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公开(公告)号：US06566328B1
公开(公告)日：2003-05-20
申请号：US09411657
申请日：1999-10-04
IPC分类号： A01N3718
摘要： The present invention relates to a method of treatment of patients by administration of human growth hormone. Also disclosed are DNA (or RNA) polynucleotide sequences that encode naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGV-3(53), as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type human growth hormone. The growth hormone variants of the present invention are of human origin and are useful for diagnostic, preventive and therapeutic purposes with respect to certain human diseases. Also disclosed is a method for producing the human growth hormone variants of the present invention by recombinant DNA techniques, as well as a method for generating antibodies directed against (and therefore inhibiting the activity of) wild-type growth hormone.
摘要翻译： 本发明涉及通过给予人生长激素治疗患者的方法。 还公开了编码人生长激素，hGHV-2（88）和hGV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列，以及其类似物和衍生物，其都缺乏通常存在的核苷酸序列 在编码野生型人生长激素的基因中。 本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断，预防和治疗目的是有用的。 还公开了通过重组DNA技术生产本发明的人生长激素变体的方法，以及用于产生针对（因此抑制）野生型生长激素的抗体的方法。
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2.发明授权
公开(公告)号：US5597709A
公开(公告)日：1997-01-28
申请号：US187756
申请日：1994-01-27
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07H21/02 , C12N15/63 , C12P21/06
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译： 提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于 编码野生型hGH的基因。 本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。 本发明还涉及通过重组DNA技术生产人生长激素变体的方法。 还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。
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公开(公告)号：US5962411A
公开(公告)日：1999-10-05
申请号：US710324
申请日：1996-09-16
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07K14/00 , A61K38/16
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译： 提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于 编码野生型hGH的基因。 本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。 本发明还涉及通过重组DNA技术生产人生长激素变体的方法。 还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。
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公开(公告)号：US06656743B2
公开(公告)日：2003-12-02
申请号：US10177158
申请日：2002-06-24
申请人： Peter L. Huson , Wei Wu He , Craig A. Rosen , Jeannine D. Gocayne
发明人： Peter L. Huson , Wei Wu He , Craig A. Rosen , Jeannine D. Gocayne
IPC分类号： C12N910
CPC分类号： C12N9/1029 , A61K38/00
摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
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公开(公告)号：US5871729A
公开(公告)日：1999-02-16
申请号：US722050
申请日：1997-01-23
IPC分类号： C12N15/09 , A61K38/00 , A61K38/44 , A61K48/00 , A61P1/04 , A61P9/06 , A61P9/10 , A61P17/02 , A61P19/02 , A61P29/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N9/02 , C12N9/04 , C12N15/53 , C12P21/08 , C12R1/91
CPC分类号： C12N9/0089 , A61K38/00
摘要： Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
摘要翻译： PCT No.PCT / US94 / 06099 Sec。 371日期1997年1月23日 102（e）日期1997年1月23日PCT提交1994年5月31日PCT公布。 WO95 / 27781 PCT出版物 日期1995年10月19日编码多肽SOD-4的多核苷酸，以及这些多肽，以及针对多肽的抗体以及多肽作为治疗脑局部缺血，溃疡，炎症，心律失常，水肿和百草枯中毒的药物的用途，作为 以及类风湿关节炎，骨关节炎和放射性损伤。
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公开(公告)号：US06635252B2
公开(公告)日：2003-10-21
申请号：US09883985
申请日：2001-06-20
IPC分类号： C07K1600
CPC分类号： C12N9/0089 , A61K38/00
摘要： Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
摘要翻译： 编码多肽SOD-4的多核苷酸，以及这些多肽，以及针对多肽的抗体以及多肽作为治疗脑局部缺血，溃疡，炎症，心律失常，水肿和百草枯中毒以及类风湿性关节炎的药物的用途， 骨关节炎和放射性损伤。
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公开(公告)号：US06319700B1
公开(公告)日：2001-11-20
申请号：US09210993
申请日：1998-12-15
IPC分类号： C12N910
CPC分类号： C12N9/1029 , A61K38/00
摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
摘要翻译： 公开了人胆碱乙酰转移酶多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗认知和神经缺陷或精神障碍如退行性神经系统疾病例如阿尔茨海默氏病，ALS和其它胆碱能缺陷的治疗方法，以及用于治疗帕金森氏病和其他与 过度表达乙酰胆碱。 还公开了用于检测人胆碱乙酰转移酶核酸序列中的突变的诊断方法。
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公开(公告)号：US07083930B2
公开(公告)日：2006-08-01
申请号：US10650721
申请日：2003-08-29
CPC分类号： C12N9/1029 , A61K38/00
摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
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公开(公告)号：US06432708B1
公开(公告)日：2002-08-13
申请号：US09939573
申请日：2001-08-28
IPC分类号： C12N516
CPC分类号： C12N9/1029 , A61K38/00
摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
摘要翻译： 公开了人胆碱乙酰转移酶多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗认知和神经缺陷或精神障碍如退行性神经系统疾病例如阿尔茨海默氏病，ALS和其它胆碱能缺陷的治疗方法，以及用于治疗帕金森氏病和其他与 过度表达乙酰胆碱。 还公开了用于检测人胆碱乙酰转移酶核酸序列中的突变的诊断方法。
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公开(公告)号：US06245540B1
公开(公告)日：2001-06-12
申请号：US08464601
申请日：1995-06-05
IPC分类号： C12N910
CPC分类号： C12N9/1029 , A61K38/00
摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
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