公开(公告)号：US07507238B2

公开(公告)日：2009-03-24

申请号：US11420719

申请日：2006-05-26

Applicant: Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

Inventor： Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

IPC: A61B18/18 ,  A61B19/00

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting a vacuum source comprising one or more suction ports into an alimentary canal; (ii) inserting an operative element comprising a conduit for a tissue ablation source into the alimentary canal; (iii) positioning the vacuum source and the operative element proximate a portion of the alimentary canal having a site of abnormal tissue to be ablated; (iv) applying a vacuum to at least one of each suction port to draw the tissue against the operative element; and (v) applying the tissue ablation source to the tissue through the conduit to effect tissue ablation.

Abstract translation: 提供了在消化道中获取和消融异常上皮组织的方法。 所述方法可以包括以下步骤：（i）将包括一个或多个吸入口的真空源插入消化道; （ii）将包括用于组织消融源的导管的操作元件插入消化道中; （iii）将真空源和操作元件定位在具有要消融的异常组织部位的消化道的一部分附近; （iv）向每个抽吸口中的至少一个施加真空以将组织拉向操作元件; 和（v）通过导管将组织消融源施加到组织以实现组织消融。

公开(公告)号：US06673070B2

公开(公告)日：2004-01-06

申请号：US09776140

申请日：2001-02-02

Applicant: Stuart D Edwards ,  John W. Gaiser ,  David S. Utley ,  Jay J. Qin

Inventor： Stuart D Edwards ,  John W. Gaiser ,  David S. Utley ,  Jay J. Qin

IPC: A61B1818

CPC classification number: A61B18/1477 ,  A61B17/32 ,  A61B18/1206 ,  A61B18/148 ,  A61B18/1485 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/22061 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/0262 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2018/183 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2218/002 ,  A61M3/0279 ,  A61M16/0438 ,  A61M16/0481 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61N1/056 ,  A61N1/06 ,  A61N1/08 ,  A61N1/40

Abstract: A sphincter treatment apparatus includes an elongated member having at least one lumen including an inflation lumen and a basket assembly with first and second arms. The basket assembly is coupled to the elongated member and has deployed and non-deployed configurations. An inflatable member is coupled to the elongated member and positioned in an interior of the basket assembly. The inflatable member has deployed and non-deployed states and is coupled to the inflation lumen. In the deployed state, the inflatable member expands the basket assembly to its deployed configuration. A first energy delivery device is positionable in the first arm and advanceable from the first arm to a selected treatment site. A second energy delivery device is positionable in the second arm and advanceable from the second arm to a selected treatment site.

Abstract translation: 括约肌治疗装置包括细长构件，其具有包括充气腔的至少一个内腔和具有第一和第二臂的篮组件。 筐组件联接到细长构件并且具有展开和非展开构造。 可膨胀构件联接到细长构件并且定位在篮组件的内部。 充气构件具有展开状态和非展开状态，并且连接到膨胀腔。 在展开状态下，可膨胀构件将篮组件膨胀到其展开构型。 第一能量输送装置可定位在第一臂中并且可从第一臂推进到选定的处理部位。 第二能量输送装置可定位在第二臂中并且可从第二臂推进到选定的治疗部位。

公开(公告)号：US06402744B2

公开(公告)日：2002-06-11

申请号：US09304750

申请日：1999-05-04

Applicant: Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

Inventor： Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

IPC: A61B1818

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Systems and methods manipulate a support structure to form a composite lesion in a tissue region at or near a sphincter. The support structure carries an array of electrodes attachable to a source of energy capable of heating tissue when transmitted by the electrodes. The systems and methods advance the electrodes to penetrate the tissue region and form, when the energy is transmitted, a first pattern of lesions. The systems and methods retract the electrodes, and shift the position of the electrodes, either rotationally, or axially, or both rotationally and axially. The systems and methods advance the electrodes a second time to form, when the energy is transmitted, a second pattern of lesions either rotationally or axially or both rotationally and axially shifted from the first pattern of lesions. The first and second patterns of lesion together comprise the composite lesion.

公开(公告)号：US08870862B2

公开(公告)日：2014-10-28

申请号：US12584509

申请日：2009-09-08

Applicant: Stuart D Edwards ,  John W. Gaiser ,  David S Utley

Inventor： Stuart D Edwards ,  John W. Gaiser ,  David S Utley

IPC: A61B18/14 ,  A61N1/06 ,  A61B18/00 ,  A61B18/12 ,  A61B18/04 ,  A61B19/00 ,  A61B17/00 ,  A61B18/02

CPC classification number: A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00039 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00142 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00791 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00982 ,  A61B2018/0237 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1467 ,  A61B2090/064 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06

Abstract: A method of regulating temperature at a tissue site comprising measuring sphincter tissue temperature at or near a tissue site, comparing the measured sphincter tissue temperature to a desired temperature, increasing an existing flow rate of a cooling solution to the tissue site if the measured tissue temperature exceeds the desired temperature, and maintaining the existing flow rate of the cooling solution to the tissue site if the measured temperature does not exceed the desired temperature.

Abstract translation: 一种调节组织部位温度的方法，包括测量组织部位处或附近的括约肌组织温度，将测得的括约肌组织温度与所需温度进行比较，如果测量的组织温度增加了冷却溶液到组织部位的现有流速 超过所需温度，并且如果测量的温度不超过所需温度，则将冷却溶液的现有流速保持在组织部位。

公开(公告)号：US08313484B2

公开(公告)日：2012-11-20

申请号：US11254951

申请日：2005-10-20

Applicant: Stuart D Edwards ,  David S Utley

Inventor： Stuart D Edwards ,  David S Utley

IPC: A61B18/14 ,  A61B19/00

CPC classification number: A61B18/1492 ,  A61B2018/00553

Abstract: A method of forming a composite lesion pattern in a tissue region at or near a sphincter comprising providing a catheter having a plurality of energy delivery devices coupled to the catheter. The catheter is introduced at least partially into the sphincter. Energy is delivered from the energy delivery devices to produce the composite lesion pattern. The composite lesion pattern comprises a radial distribution of lesions about the tissue region and a longitudinal distribution of lesions along the tissue region.

Abstract translation: 在括约肌处或附近在组织区域中形成复合损伤图案的方法，包括提供具有耦合到导管的多个能量输送装置的导管。 将导管至少部分地引入括约肌。 能量从能量输送装置输送以产生复合损伤模式。 复合损伤图案包括围绕组织区域的损伤的径向分布和沿着组织区域的损伤的纵向分布。

公开(公告)号：US06971395B2

公开(公告)日：2005-12-06

申请号：US10428458

申请日：2003-05-02

Applicant: Stuart D Edwards ,  David S Utley

Inventor： Stuart D Edwards ,  David S Utley

IPC: A61B18/14 ,  A61B19/00

CPC classification number: A61B18/1492 ,  A61B2018/00553

Abstract: A method of forming a composite lesion pattern in a tissue region at or near a sphincter comprising providing a catheter having a plurality of energy delivery devices coupled to the catheter. The catheter is introduced at least partially into the sphincter. Energy is delivered from the energy delivery devices to produce the composite lesion pattern. The composite lesion pattern comprises a radial distribution of lesions about the tissue region and a longitudinal distribution of lesions along the tissue region.

Abstract translation: 在括约肌处或附近在组织区域中形成复合损伤图案的方法，包括提供具有耦合到导管的多个能量输送装置的导管。 将导管至少部分地引入括约肌。 能量从能量输送装置输送以产生复合损伤模式。 复合损伤图案包括围绕组织区域的损伤的径向分布和沿着组织区域的损伤的纵向分布。

公开(公告)号：US06872206B2

公开(公告)日：2005-03-29

申请号：US10247153

申请日：2002-09-19

Applicant: Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott H West ,  Jay Qin

Inventor： Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott H West ,  Jay Qin

IPC: A61B18/00 ,  A61B18/04 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Methods treat a tissue region. In one arrangement, the methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. In one embodiment, the support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region.

公开(公告)号：US06712814B2

公开(公告)日：2004-03-30

申请号：US09973467

申请日：2001-10-09

Applicant: Stuart D Edwards ,  David S Utley

Inventor： Stuart D Edwards ,  David S Utley

IPC: A61B1818

CPC classification number: A61B5/04884 ,  A61B5/01 ,  A61B5/0535 ,  A61B8/00 ,  A61B18/00 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/148 ,  A61B18/1485 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22062 ,  A61B2017/22072 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00267 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00738 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/0262 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2218/002 ,  A61F7/12 ,  A61M3/0279 ,  A61M16/0438 ,  A61M16/0481 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61N1/056 ,  A61N1/06 ,  A61N1/08 ,  A61N1/40 ,  C08L2201/12

Abstract: A method of treating a sphincter that provides an expandable basket structure with a first energy delivery device. The basket structure is introduced in a sphincter. The first energy delivery device is advanced from the basket structure into an interior of the sphincter. Sufficient energy is delivered from the first energy delivery device to create a desired tissue effect in the sphincter. Thereafter, the basket structure is removed from the sphincter.

Abstract translation: 一种治疗括约肌的方法，所述括约肌提供具有第一能量递送装置的可扩张篮结构。 篮子结构被引入括约肌。 第一能量输送装置从篮状结构进入括约肌的内部。 从第一能量递送装置输送足够的能量以在括约肌中产生期望的组织效应。 此后，将括号结构从括约肌中取出。

公开(公告)号：US06562034B2

公开(公告)日：2003-05-13

申请号：US10046637

申请日：2002-01-14

Applicant: Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

Inventor： Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

IPC: A61B1818

CPC classification number: A61B18/1485 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/00738 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2090/036 ,  C08L2201/12

Abstract: Improved electrode assemblies for treating a tissue region at or near a sphincter comprise a support structure and an electrode carried by the support structure for advancement in a path to penetrate the tissue region. In one arrangement, the electrode has a non-cylindrical cross section selected to resist deflection when advanced to penetrate the tissue region. In another arrangement, the electrode includes a tissue stop to resist tissue penetration beyond a selected depth. In another arrangement, the electrode includes a proximal portion formed from a first material and a distal tissue penetrating portion formed of a second material different than the first material. The first material can comprise, e.g., stainless steel, and the second material can comprise, e.g., nickel titanium.

公开(公告)号：US06423058B1

公开(公告)日：2002-07-23

申请号：US09304770

申请日：1999-05-04

Applicant: Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

Inventor： Stuart D Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

IPC: A61B1818

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Assemblies for treating a tissue region at or near a sphincter have a support structure with a distal end and an electrode carried by the support structure for contact with the tissue region. A lumen in the support structure accommodates passage of a body through the support structure and beyond the distal end of the support structure. The body can comprise a guide wire to guide deployment of the support structure, or an endoscope to permit visualization of the support structure from beyond the distal end of the support structure.

Abstract translation: 用于治疗括约肌处或附近的组织区域的组件具有支撑结构，其具有远端和由支撑结构承载的用于与组织区域接触的电极。 支撑结构中的内腔容纳主体通过支撑结构并超出支撑结构的远端的通道。 主体可以包括引导线以引导支撑结构的展开，或内窥镜，以允许从支撑结构的远端超出支撑结构的可视化。